Protein: PP12
Serine/threonine-protein phosphatase alpha-2 isoform (EC 3.1.3.16)

Gene: PP12, Pp1-87B
Organism: Drosophila melanogaster
Interactions: 98
UniProt ID: P12982

Gene Ontology (top 5):
GO:0000164 - protein phosphatase type 1 complex
GO:0000278 - mitotic cell cycle
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005700 - polytene chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

559026

PP1B
Serine/threonine-protein phosphatase beta isoform

4

13

High-throughput

0.861

High

559066

Q9VEK8
GH07711p

3

20

Small-scale

0.817

High

559057

Q9V3C7
Inhibitor-2

4

20

High-throughput

0.754

High

559047

Q8SWT8
Protein phosphatase 1 regulatory subunit

2

20

Small-scale

0.754

High

559035

Q4V424
IP09433p

3

20

High-throughput

0.746

High

68611

A8JNP7
Inhibitor-2, isoform B

3

20

High-throughput

0.741

High

559052

Q8T0U6
Serine/threonine-protein phosphatase

2

13

High-throughput

0.712

High

559081

Q9VRC5
E3 ubiquitin-protein ligase PPP1R11

1

11

High-throughput

0.656

High

559086

GBS76
Glycogen-binding subunit 76A

1

20

High-throughput

0.656

High

559059

Q9V7W9
Nuclear inhibitor of protein phosphatase 1

3

9

Small-scale

0.649

High

559023

SQH
Myosin regulatory light chain sqh

1

6

Small-scale

0.647

High

559032

KTU
Protein kintoun

2

9

High-throughput

0.640

High

559042

Q7KU01
Phosphatase 1 nuclear targeting subunit, isoform D

2

16

Small-scale

0.627

High

559041

SCRIB
Protein lap4

1

15

High-throughput

0.625

High

559055

Q95TZ7
GH19182p

1

12

High-throughput

0.621

High

559029

FKB39
39 kDa FK506-binding nuclear protein

1

3

Small-scale

0.618

High

559065

SUR8
Leucine-rich repeat protein soc-2 homolog

1

17

Small-scale

0.618

High

559077

Q9VMI2
E3 ubiquitin-protein ligase PPP1R11

1

20

High-throughput

0.618

High

559072

Q9VIP4
LP17758p

2

14

Small-scale

0.609

High

559040

Q7K9H6
Zinc finger FYVE domain-containing protein

2

17

Small-scale

0.595

High

559074

Q9VK43
LD10135p

3

3

High-throughput

0.594

High

559083

Q9VUF3
Protein phosphatase 1 regulatory subunit

1

20

High-throughput

0.590

High

559079

Q9VMW2
Reticulon-like protein

2

2

High-throughput

0.584

High

559099

RIF1
Telomere-associated protein RIF1

2

3

Small-scale

0.584

High

118596

M9NF08
ZAP3, isoform D

2

7

High-throughput

0.584

High

71893

A8QI94
Serine/threonine-protein phosphatase

1

14

High-throughput

0.575

High

559097

Q9W2Y5
YLP motif-containing protein 1

2

11

High-throughput

0.565

High

559020

TRX
Histone-lysine N-methyltransferase trithorax

2

5

High-throughput

0.560

High

559094

URI
Unconventional prefoldin RPB5 interactor-like protein

1

3

Small-scale

0.552

High

559078

Q9VMV9
Reticulon-like protein

2

2

High-throughput

0.552

High

559080

Q9VQS4
Spindly

2

3

High-throughput

0.550

High

559102

X2JKX2
Corolla, isoform B

2

7

High-throughput

0.533

High

559088

Q9VX37
Corolla, isoform A

2

7

High-throughput

0.516

High

559073

Q9VJE7
AT25465p

1

20

High-throughput

0.514

High

57229

A1ZAW3
FI17823p1

1

5

High-throughput

0.508

High

262652

LOK
Ovarian-specific serine/threonine-protein kinase Lok

1

6

High-throughput

0.508

High

559021

CDK2
Cyclin-dependent kinase 2

1

13

High-throughput

0.508

High

559028

DOA
Serine/threonine-protein kinase Doa

1

13

High-throughput

0.508

High

559038

Q7K306
cyclin-dependent kinase

1

14

High-throughput

0.508

High

559039

MARS
Guanylate kinase-associated protein mars

1

5

High-throughput

0.508

High

559043

Q86B80
Uncharacterized protein, isoform A

1

3

High-throughput

0.508

High

559051

Q8T0D1
LD10183p

1

3

High-throughput

0.508

High

559095

Q9W1E4
GH11727p

1

3

High-throughput

0.508

High

121649

M9PFV2
Myosin phosphatase targeting subunit 75D, isoform B

1

20

Small-scale

0.501

High

69283

A8JUY3
DNA-directed RNA polymerase subunit

1

8

High-throughput

0.481

High

121965

M9PH39
histone acetyltransferase

1

10

High-throughput

0.481

High

559056

SIRT2
NAD-dependent protein deacetylase Sirt2

1

5

High-throughput

0.481

High

559101

X2J8G3
Mrityu, isoform E

1

10

High-throughput

0.481

High

68698

A8JQV1
Uncharacterized protein, isoform C

1

3

High-throughput

0.479

High

458795

PER
Period circadian protein

1

7

Small-scale

0.479

High

559022

PC
Polycomb group protein Pc

1

2

Small-scale

0.479

High

559025

MOEH
Moesin/ezrin/radixin homolog 1

1

10

Small-scale

0.479

High

559027

TIM
Protein timeless

1

3

Small-scale

0.479

High

559053

Q94533
Ribosomal protein S6 kinase

1

10

High-throughput

0.479

High

559062

CRERF
Protein CREBRF homolog

1

1

Small-scale

0.479

High

559064

Q9VEH1
LD04521p

1

20

Small-scale

0.479

High

559084

Q9VUX7
GH16214p

1

17

Small-scale

0.479

High

559096

Q9W2J2
Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, isoform A

1

20

Small-scale

0.479

High

559046

Q8MRN4
GH12664p

1

3

High-throughput

0.464

High

559058

Q9V4B8
RE68558p

1

6

High-throughput

0.464

High

559063

Q9VDX4
MIP05121p

1

3

High-throughput

0.464

High

559067

Q9VF13
Uncharacterized protein, isoform C

1

20

High-throughput

0.464

High

559070

Q9VGJ2
Inhibitor-t

1

1

High-throughput

0.464

High

559087

Q9VWB7
LD06925p

1

6

High-throughput

0.464

High

559089

Q9VXK9
Centrosomal protein 164, isoform A

1

1

High-throughput

0.464

High

559031

Q0E8K5
AT10158p

1

10

High-throughput

0.457

High

559037

Q7JMZ1
Kinesin-like protein

1

14

High-throughput

0.457

High

559044

Q8IQB4
Z band alternatively spliced PDZ-motif protein 66, isoform E

1

8

High-throughput

0.457

High

559048

Q8SXG7
tRNA selenocysteine-associated protein 1

1

9

High-throughput

0.457

High

559054

Q95TP4
LD33277p

1

1

High-throughput

0.457

High

559092

Q9VZM9
RE59328p

1

7

High-throughput

0.457

High

559024

LA
La protein homolog

1

13

High-throughput

0.445

High

559036

Q4V467
IP10845p

1

3

High-throughput

0.445

High

559075

WDR12
Ribosome biogenesis protein WDR12 homolog

1

8

High-throughput

0.445

High

559093

Q9W0L7
ubiquitinyl hydrolase 1

1

2

High-throughput

0.445

High

122070

M9PHL2
Heterochromatin protein 5, isoform C

1

1

High-throughput

0.439

High

559033

Q1W9Q0
Echinus splice form 1

1

7

High-throughput

0.439

High

559098

Q9W4P6
Oligopeptide transporter 1

1

1

High-throughput

0.439

High

559100

R9PY70
Uncharacterized protein, isoform G

1

7

High-throughput

0.439

High

559030

SMO
Protein smoothened

1

12

Small-scale

0.437

High

559090

Q9VYW3
GEO08380p1

1

0

High-throughput

0.426

High

305314

O77283
Echinus

1

7

High-throughput

0.417

High

559045

Q8IRT1
Oligopeptide transporter 1

1

1

High-throughput

0.417

High

559050

Q8SYZ4
NAD-dependent protein deacetylase

1

5

High-throughput

0.417

High

559060

Q9V9N7
GH01875p

1

7

High-throughput

0.417

High

559091

Q9VYY7
Heterochromatin protein 5, isoform B

1

1

High-throughput

0.417

High

559061

Q9VAJ2
Mitotic checkpoint protein BUB3

1

11

High-throughput

0.407

High

559076

WDR82
WD repeat-containing protein 82

1

17

High-throughput

0.407

High

559082

Q9VRD4
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

195836

O16866
Kinesin-like protein, KLP38B

1

14

High-throughput

0.381

High

195202

O16125
Bifocal

1

0

High-throughput

0.365

High

356017

O96723
Inhibitor-t protein

1

1

High-throughput

0.348

High

559034

Q4QPV3
IP04645p

1

0

High-throughput

0.265

Low

559069

Q9VGI1
FI23955p1

1

0

High-throughput

0.265

Low

559071

Q9VIB1
Carboxylic ester hydrolase

1

0

High-throughput

0.265

Low

559085

Q9VVQ1
Allatostatin C receptor 1

1

0

High-throughput

0.265

Low

559049

Q8SYP1
RE49668p

1

0

High-throughput

0.232

Low

559068

RT10
Small ribosomal subunit protein uS10m

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025