Protein: HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34)

Gene: HMDH, HMGCR
Organism: Homo sapiens
Interactions: 91
UniProt ID: P04035

Gene Ontology (top 5):
GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005778 - peroxisomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006695 - cholesterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181030

INSI1
Insulin-induced gene 1 protein

6

3

Small-scale

0.931

High

373121

PTHD3
Patched domain-containing protein 3

1

6

High-throughput

0.691

High

373164

AMFR
E3 ubiquitin-protein ligase AMFR

3

12

Small-scale

0.656

High

373169

INSI2
Insulin-induced gene 2 protein

1

3

Small-scale

0.618

High

373170

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

Small-scale

0.612

High

299810

ERLN2
Erlin-2

2

4

Small-scale

0.611

High

373128

RIC3
Protein RIC-3

2

0

High-throughput

0.585

High

373092

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

3

High-throughput

0.584

High

373104

PI2R
Prostacyclin receptor

2

2

High-throughput

0.574

High

373120

GBRA6
Gamma-aminobutyric acid receptor subunit alpha-6

2

2

High-throughput

0.574

High

373135

AGRG5
Adhesion G-protein coupled receptor G5

2

2

High-throughput

0.574

High

373152

KCNS3
Potassium voltage-gated channel subfamily S member 3

2

1

High-throughput

0.574

High

373108

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

2

3

High-throughput

0.558

High

160992

CLGN
Calmegin

1

5

High-throughput

0.536

High

373096

CP19A
Aromatase

1

1

High-throughput

0.536

High

373098

CALX
Calnexin

1

5

High-throughput

0.536

High

373099

V2R
Vasopressin V2 receptor

1

1

High-throughput

0.536

High

373101

CP2CI
Cytochrome P450 2C18

1

1

High-throughput

0.536

High

373109

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.536

High

373114

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

4

High-throughput

0.536

High

373122

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

373130

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

12

High-throughput

0.536

High

373154

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.536

High

373117

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

235320

ADCY9
Adenylate cyclase type 9

1

1

High-throughput

0.489

High

373100

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.489

High

373102

P2RY2
P2Y purinoceptor 2

1

5

High-throughput

0.489

High

373103

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

3

High-throughput

0.489

High

373107

CCR6
C-C chemokine receptor type 6

1

1

High-throughput

0.489

High

373111

IDD
Integral membrane protein DGCR2/IDD

1

4

High-throughput

0.489

High

373112

ACHD
Acetylcholine receptor subunit delta

1

3

High-throughput

0.489

High

373115

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

373125

BTNL3
Butyrophilin-like protein 3

1

7

High-throughput

0.489

High

373132

P2RY8
P2Y purinoceptor 8

1

5

High-throughput

0.489

High

373138

ACV1C
Activin receptor type-1C

1

2

High-throughput

0.489

High

373155

LPAR2
Lysophosphatidic acid receptor 2

1

6

High-throughput

0.489

High

373166

PCDB3
Protocadherin beta-3

1

2

High-throughput

0.489

High

373167

PCDGL
Protocadherin gamma-C4

1

2

High-throughput

0.489

High

163720

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

5

High-throughput

0.479

High

373093

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

373094

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.479

High

373110

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

373113

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.479

High

373137

RN148
RING finger protein 148

1

14

High-throughput

0.479

High

373140

RN139
E3 ubiquitin-protein ligase RNF139

1

11

Small-scale

0.479

High

373142

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

11

High-throughput

0.479

High

373145

FAF2
FAS-associated factor 2

1

2

High-throughput

0.479

High

373151

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

373158

CC50A
Cell cycle control protein 50A

1

1

High-throughput

0.479

High

373168

SRPRB
Signal recognition particle receptor subunit beta

1

4

High-throughput

0.479

High

373171

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

1

Small-scale

0.479

High

68220

HECA2
HEPACAM family member 2

1

1

High-throughput

0.437

High

199858

SPIT2
Kunitz-type protease inhibitor 2

1

1

High-throughput

0.437

High

204908

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.437

High

295705

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

1

High-throughput

0.437

High

373095

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.437

High

373118

ELOB
Elongin-B

1

1

High-throughput

0.437

High

373119

EREP1
Endosomal transmembrane epsin interactor 1

1

1

High-throughput

0.437

High

373124

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

373126

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

373127

BT2A1
Butyrophilin subfamily 2 member A1

1

7

High-throughput

0.437

High

373129

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.437

High

373131

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

2

High-throughput

0.437

High

373133

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.437

High

373134

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

373136

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

373143

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.437

High

373161

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

2

High-throughput

0.437

High

373162

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

1

3

High-throughput

0.437

High

99537

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

373116

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.407

High

373149

CK5P2
CDK5 regulatory subunit-associated protein 2

1

1

High-throughput

0.407

High

373157

CD209
CD209 antigen

3

0

High-throughput

0.347

High

373106

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

2

0

High-throughput

0.328

High

373097

INSRR
Insulin receptor-related protein

1

0

High-throughput

0.279

Low

373123

TM268
Transmembrane protein 268

1

0

High-throughput

0.279

Low

373139

O13J1
Olfactory receptor 13J1

1

0

High-throughput

0.279

Low

373141

CC107
Coiled-coil domain-containing protein 107

1

0

High-throughput

0.279

Low

373146

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

373147

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.279

Low

373148

SORC2
VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]

1

0

High-throughput

0.279

Low

373156

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.279

Low

373159

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

373160

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.279

Low

373163

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

373165

STA13
StAR-related lipid transfer protein 13

1

0

Small-scale

0.265

Low

308304

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

373105

DYN2
Dynamin-2

1

0

High-throughput

0.249

Low

373144

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

373150

KCNKG
Potassium channel subfamily K member 16

1

0

High-throughput

0.249

Low

373153

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.213

Low


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Last updated: 15 Jul 2024