Protein: P85B
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)

Gene: P85B, PIK3R2
Organism: Homo sapiens
Interactions: 222
UniProt ID: O00459

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0001784 - phosphotyrosine residue binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005925 - focal adhesion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

129230

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

10

20

Small-scale

0.974

High

129152

EGFR
Epidermal growth factor receptor

11

20

Small-scale

0.973

High

129231

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

8

20

Small-scale

0.973

High

129206

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

8

19

Small-scale

0.965

High

129159

ERBB2
Receptor tyrosine-protein kinase erbB-2

5

20

Small-scale

0.917

High

129237

CRK
Adapter molecule crk

5

20

High-throughput

0.915

High

129200

ERBB3
Receptor tyrosine-protein kinase erbB-3

4

20

Small-scale

0.899

High

129228

TGFR2
TGF-beta receptor type-2

4

12

Small-scale

0.895

High

129321

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

4

20

High-throughput

0.895

High

129269

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.875

High

129178

KIT
Mast/stem cell growth factor receptor Kit

3

20

Small-scale

0.843

High

129344

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

4

High-throughput

0.811

High

126184

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

2

20

Small-scale

0.806

High

129238

CRKL
Crk-like protein

2

20

Small-scale

0.806

High

129153

RASK
GTPase KRas

2

20

High-throughput

0.793

High

129295

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

20

Small-scale

0.789

High

129160

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.789

High

129171

IGF1R
Insulin-like growth factor 1 receptor

2

20

Small-scale

0.783

High

129229

STAT3
Signal transducer and activator of transcription 3

2

20

High-throughput

0.767

High

129184

FGFR1
Fibroblast growth factor receptor 1

2

20

Small-scale

0.757

High

129267

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

129202

CBL
E3 ubiquitin-protein ligase CBL

7

20

Small-scale

0.741

High

129215

UFO
Tyrosine-protein kinase receptor UFO

2

20

Small-scale

0.738

High

129176

PGFRB
Platelet-derived growth factor receptor beta

2

20

Small-scale

0.737

High

129257

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

13

Small-scale

0.724

High

129172

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

129144

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

High-throughput

0.691

High

129162

INSR
Insulin receptor

1

20

High-throughput

0.691

High

129212

SHC1
SHC-transforming protein 1

1

19

High-throughput

0.691

High

129250

JAK3
Tyrosine-protein kinase JAK3

1

20

High-throughput

0.691

High

129256

ANM2
Protein arginine N-methyltransferase 2

1

6

High-throughput

0.691

High

129283

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.691

High

129141

IRS4
Insulin receptor substrate 4

3

20

High-throughput

0.675

High

129251

EFNB2
Ephrin-B2

3

9

High-throughput

0.667

High

129315

SKAP1
Src kinase-associated phosphoprotein 1

3

20

High-throughput

0.667

High

129284

DDR1
Epithelial discoidin domain-containing receptor 1

2

20

Small-scale

0.659

High

129236

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.656

High

129164

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.647

High

129165

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

Small-scale

0.647

High

129180

GHR
Growth hormone receptor

1

20

Small-scale

0.647

High

129316

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

129286

DLG1
Disks large homolog 1

1

20

Small-scale

0.646

High

129148

KRT38
Keratin, type I cuticular Ha8

2

20

High-throughput

0.646

High

129326

HAUS1
HAUS augmin-like complex subunit 1

3

0

High-throughput

0.638

High

129335

HAUS4
HAUS augmin-like complex subunit 4

3

0

High-throughput

0.638

High

129244

ARRB1
Beta-arrestin-1

2

9

High-throughput

0.633

High

129196

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.631

High

129309

RN19B
E3 ubiquitin-protein ligase RNF19B

2

13

High-throughput

0.628

High

129348

IKZF3
Zinc finger protein Aiolos

2

10

High-throughput

0.628

High

69198

A9UF07
non-specific protein-tyrosine kinase

1

19

High-throughput

0.625

High

129232

TEC
Tyrosine-protein kinase Tec

1

20

Small-scale

0.621

High

129213

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.618

High

129350

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

120196

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

129140

SOCS6
Suppressor of cytokine signaling 6

1

19

Small-scale

0.618

High

129146

SOCS1
Suppressor of cytokine signaling 1

1

19

Small-scale

0.618

High

129151

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

129163

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

129169

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

129173

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

129182

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.618

High

129190

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

129191

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.618

High

129193

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

129199

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.618

High

129208

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

129209

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.618

High

129211

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

129225

VGFR3
Vascular endothelial growth factor receptor 3

1

20

High-throughput

0.618

High

129246

RAB7A
Ras-related protein Rab-7a

1

13

High-throughput

0.618

High

129249

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

129253

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

129258

ACTB
Actin, cytoplasmic 1

1

17

High-throughput

0.618

High

129259

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

129260

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

129261

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.618

High

129262

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

129263

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

129270

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

129275

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

129294

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

129298

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

129300

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

129312

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

129323

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

129338

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

129149

RCBT2
RCC1 and BTB domain-containing protein 2

3

6

High-throughput

0.609

High

129234

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

14

High-throughput

0.609

High

129183

LAMP1
Lysosome-associated membrane glycoprotein 1

2

12

High-throughput

0.584

High

129219

IRS1
Insulin receptor substrate 1

2

20

Small-scale

0.584

High

129170

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.578

High

129347

DP13A
DCC-interacting protein 13-alpha

2

18

High-throughput

0.576

High

129185

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.575

High

129282

FAK1
Focal adhesion kinase 1

1

20

Small-scale

0.575

High

129303

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.574

High

129319

HAVR2
Hepatitis A virus cellular receptor 2

2

6

High-throughput

0.574

High

129337

MANS1
MANSC domain-containing protein 1

2

2

High-throughput

0.574

High

129223

K1C20
Keratin, type I cytoskeletal 20

1

20

High-throughput

0.573

High

129226

TRI23
E3 ubiquitin-protein ligase TRIM23

1

11

High-throughput

0.573

High

129285

GOGA2
Golgin subfamily A member 2

1

19

High-throughput

0.573

High

129307

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.573

High

129197

VCAM1
Vascular cell adhesion protein 1

2

20

High-throughput

0.571

High

129204

1433T
14-3-3 protein theta

1

20

Small-scale

0.561

High

129346

FBXL2
F-box/LRR-repeat protein 2

1

3

Small-scale

0.561

High

68217

HECA2
HEPACAM family member 2

2

20

High-throughput

0.558

High

129189

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.553

High

129198

EPHA1
Ephrin type-A receptor 1

1

20

High-throughput

0.553

High

129201

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

129210

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.553

High

129252

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

129278

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.553

High

129297

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.553

High

129299

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.553

High

129306

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.553

High

129310

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

129334

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

129177

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

129290

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

129158

SEMG1
Semenogelin-1

1

1

High-throughput

0.536

High

129168

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.536

High

129175

CD7
T-cell antigen CD7

1

1

High-throughput

0.536

High

129235

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

2

High-throughput

0.536

High

129265

1433E
14-3-3 protein epsilon

1

10

High-throughput

0.536

High

129268

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.536

High

129271

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

129274

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

129276

EFNB1
Ephrin-B1

1

9

High-throughput

0.536

High

129279

SEMG2
Semenogelin-2

1

1

High-throughput

0.536

High

129293

CUL3
Cullin-3

1

10

High-throughput

0.536

High

129308

PKN3
Serine/threonine-protein kinase N3

1

20

High-throughput

0.536

High

129324

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

11

High-throughput

0.536

High

129331

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

129339

WDR6
tRNA

1

15

High-throughput

0.536

High

129351

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.536

High

129353

NISCH
Nischarin

1

11

High-throughput

0.536

High

129216

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.515

High

129332

MED28
Mediator of RNA polymerase II transcription subunit 28

1

11

Small-scale

0.515

High

129314

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

20

High-throughput

0.515

High

129161

A4
Amyloid-beta precursor protein

1

15

High-throughput

0.501

High

129207

GRN
Progranulin

1

1

High-throughput

0.494

High

129145

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.489

High

129242

V1BR
Vasopressin V1b receptor

1

14

High-throughput

0.489

High

129317

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

129355

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.489

High

129155

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.481

High

129255

LAMB2
Laminin subunit beta-2

1

8

High-throughput

0.481

High

129139

DDX3X
ATP-dependent RNA helicase DDX3X

1

7

High-throughput

0.479

High

129142

AURKA
Aurora kinase A

1

20

High-throughput

0.479

High

129143

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.479

High

129147

FLOT1
Flotillin-1

1

11

High-throughput

0.479

High

129154

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.479

High

129156

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

129157

K2C1
Keratin, type II cytoskeletal 1

1

18

High-throughput

0.479

High

129166

TBB5
Tubulin beta chain

1

16

High-throughput

0.479

High

129174

K1C16
Keratin, type I cytoskeletal 16

1

20

High-throughput

0.479

High

129179

CD28
T-cell-specific surface glycoprotein CD28

1

11

Small-scale

0.479

High

129181

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

129186

ITA4
Integrin alpha-4

1

10

High-throughput

0.479

High

129187

K1C10
Keratin, type I cytoskeletal 10

1

20

High-throughput

0.479

High

129188

K2C5
Keratin, type II cytoskeletal 5

1

20

High-throughput

0.479

High

129192

HSP76
Heat shock 70 kDa protein 6

1

20

High-throughput

0.479

High

129194

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

129195

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

20

High-throughput

0.479

High

129205

DPP4
Dipeptidyl peptidase 4

1

5

High-throughput

0.479

High

129214

MARCS
Myristoylated alanine-rich C-kinase substrate

1

20

High-throughput

0.479

High

129217

HS71L
Heat shock 70 kDa protein 1-like

1

20

High-throughput

0.479

High

129218

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.479

High

129220

MYH9
Myosin-9

1

13

High-throughput

0.479

High

129221

MYH10
Myosin-10

1

13

High-throughput

0.479

High

129222

FUS
RNA-binding protein FUS

1

10

High-throughput

0.479

High

129224

K22E
Keratin, type II cytoskeletal 2 epidermal

1

20

High-throughput

0.479

High

129227

TGFR1
TGF-beta receptor type-1

1

12

Small-scale

0.479

High

129239

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.479

High

129240

RS10
Small ribosomal subunit protein eS10

1

3

High-throughput

0.479

High

129241

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

High-throughput

0.479

High

129243

K2C6C
Keratin, type II cytoskeletal 6C

1

20

High-throughput

0.479

High

129247

CCR5
C-C chemokine receptor type 5

1

13

Small-scale

0.479

High

129248

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

16

High-throughput

0.479

High

129254

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

129266

ARF6
ADP-ribosylation factor 6

1

6

High-throughput

0.479

High

129272

EF1A1
Elongation factor 1-alpha 1

1

6

High-throughput

0.479

High

129277

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.479

High

129280

CAV1
Caveolin-1

1

15

High-throughput

0.479

High

129281

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.479

High

129287

ACACA
Acetyl-CoA carboxylase 1

1

7

High-throughput

0.479

High

129288

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

129289

CBLB
E3 ubiquitin-protein ligase CBL-B

1

20

Small-scale

0.479

High

129291

SMAD4
Mothers against decapentaplegic homolog 4

1

6

High-throughput

0.479

High

129292

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

129296

KS6A2
Ribosomal protein S6 kinase alpha-2

1

20

High-throughput

0.479

High

129304

K2C79
Keratin, type II cytoskeletal 79

1

20

High-throughput

0.479

High

129313

MYH14
Myosin-14

1

13

High-throughput

0.479

High

129328

DNJC7
DnaJ homolog subfamily C member 7

1

13

High-throughput

0.479

High

129329

TBA1C
Tubulin alpha-1C chain

1

20

High-throughput

0.479

High

129330

TBB6
Tubulin beta-6 chain

1

16

High-throughput

0.479

High

129333

DNJC5
DnaJ homolog subfamily C member 5

1

11

High-throughput

0.479

High

129336

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

129340

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

129349

COR1C
Coronin-1C

1

10

High-throughput

0.479

High

129354

NINL
Ninein-like protein

1

19

High-throughput

0.479

High

103676

G5E9A7
DM1 locus, WD repeat containing

1

14

High-throughput

0.470

High

129264

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

129318

ENKUR
Enkurin

1

1

Small-scale

0.457

High

129233

HD
Huntingtin

1

8

High-throughput

0.457

High

129203

CCND1
G1/S-specific cyclin-D1

1

5

High-throughput

0.445

High

129302

MK06
Mitogen-activated protein kinase 6

1

9

High-throughput

0.445

High

129341

LTBP3
Latent-transforming growth factor beta-binding protein 3

1

14

High-throughput

0.439

High

129343

STAB1
Stabilin-1

1

10

High-throughput

0.439

High

129167

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

4

Small-scale

0.437

High

129245

R144A
E3 ubiquitin-protein ligase RNF144A

1

8

Small-scale

0.437

High

129273

CXAR
Coxsackievirus and adenovirus receptor

1

20

High-throughput

0.437

High

129301

OCLN
Occludin

1

6

High-throughput

0.437

High

129305

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.437

High

129322

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

129325

CK052
Uncharacterized protein C11orf52

1

3

High-throughput

0.437

High

129342

RED2
Double-stranded RNA-specific editase B2

1

5

High-throughput

0.437

High

129345

DNJ5B
DnaJ homolog subfamily C member 5B

1

11

High-throughput

0.437

High

129352

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

20

High-throughput

0.437

High

129327

MR1L1
MORF4 family-associated protein 1-like 1

2

0

High-throughput

0.334

High

129320

DYDC1
DPY30 domain-containing protein 1

1

0

High-throughput

0.299

High

129150

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.279

Low

129311

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024