Protein: P66A
Transcriptional repressor p66-alpha (Hp66alpha) (GATA zinc finger domain-containing protein 2A)

Gene: P66A, GATAD2A
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q86YP4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling
GO:0016581 - NuRD complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1205828

MBD2
Methyl-CpG-binding domain protein 2

11

7

Small-scale

0.979

High

328592

MBD3
Methyl-CpG-binding domain protein 3

9

7

Small-scale

0.971

High

1205783

MB3L1
Methyl-CpG-binding domain protein 3-like 1

5

7

High-throughput

0.926

High

1205806

MTA3
Metastasis-associated protein MTA3

4

5

High-throughput

0.903

High

296066

MTA2
Metastasis-associated protein MTA2

4

5

Small-scale

0.895

High

1031896

MTA1
Metastasis-associated protein MTA1

4

5

Small-scale

0.892

High

1038507

HDAC1
Histone deacetylase 1

10

4

Small-scale

0.758

High

997792

RBBP4
Histone-binding protein RBBP4

7

5

Small-scale

0.751

High

1205788

HDAC2
Histone deacetylase 2

8

4

Small-scale

0.750

High

1083302

RBBP7
Histone-binding protein RBBP7

7

5

Small-scale

0.749

High

1059715

CHD4
Chromodomain-helicase-DNA-binding protein 4

7

13

Small-scale

0.746

High

146832

CDKA1
Cyclin-dependent kinase 2-associated protein 1

6

3

Small-scale

0.732

High

1205836

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

5

7

Small-scale

0.718

High

934944

H31
Histone H3.1

5

5

Small-scale

0.704

High

1018565

CHD3
Chromodomain-helicase-DNA-binding protein 3

4

13

High-throughput

0.699

High

1205779

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

7

High-throughput

0.691

High

1205832

TRPS1
Zinc finger transcription factor Trps1

1

10

High-throughput

0.691

High

1205773

ZN687
Zinc finger protein 687

3

1

High-throughput

0.675

High

898959

PSME3
Proteasome activator complex subunit 3

3

1

High-throughput

0.667

High

934286

CSK21
Casein kinase II subunit alpha

3

5

High-throughput

0.667

High

1200808

ZBT46
Zinc finger and BTB domain-containing protein 46

3

8

High-throughput

0.667

High

1205780

CHD5
Chromodomain-helicase-DNA-binding protein 5

3

13

Small-scale

0.667

High

1205827

ZN219
Zinc finger protein 219

3

1

High-throughput

0.667

High

853643

IMA5
Importin subunit alpha-5

2

4

High-throughput

0.628

High

1205785

ZN592
Zinc finger protein 592

2

1

High-throughput

0.628

High

1087238

H2B2E
Histone H2B type 2-E

2

4

Small-scale

0.619

High

798940

GATA4
Transcription factor GATA-4

1

4

High-throughput

0.618

High

68297

P20L1
PHD finger protein 20-like protein 1

2

1

High-throughput

0.611

High

470078

H2AZ
Histone H2A.Z

2

5

High-throughput

0.611

High

586840

CSK22
Casein kinase II subunit alpha'

2

5

High-throughput

0.611

High

818216

SOX2
Transcription factor SOX-2

2

14

High-throughput

0.611

High

974602

MECOM
Histone-lysine N-methyltransferase MECOM

2

4

High-throughput

0.611

High

1033672

IKZF1
DNA-binding protein Ikaros

2

3

High-throughput

0.611

High

1205797

Z512B
Zinc finger protein 512B

2

2

High-throughput

0.611

High

1205821

SALL1
Sal-like protein 1

2

6

High-throughput

0.611

High

1205768

F219A
Protein FAM219A

3

1

High-throughput

0.609

High

779695

CCNF
Cyclin-F

2

1

High-throughput

0.601

High

917543

H4
Histone H4

2

1

Small-scale

0.595

High

1205784

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.586

High

244630

BRD4
Bromodomain-containing protein 4

2

9

High-throughput

0.584

High

347236

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

1063480

SUZ12
Polycomb protein SUZ12

2

1

High-throughput

0.584

High

1067035

BRD3
Bromodomain-containing protein 3

2

9

High-throughput

0.584

High

1080095

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

High-throughput

0.584

High

280634

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.553

High

1055189

K1H2
Keratin, type I cuticular Ha2

2

2

High-throughput

0.553

High

455620

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.536

High

509050

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

853359

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.536

High

996753

SSRP1
FACT complex subunit SSRP1

1

10

High-throughput

0.536

High

1089314

ZN827
Zinc finger protein 827

1

4

Small-scale

0.536

High

1205787

THRSP
Thyroid hormone-inducible hepatic protein

1

1

High-throughput

0.536

High

1205809

BC11B
B-cell lymphoma/leukemia 11B

1

3

High-throughput

0.536

High

1205818

CPNE5
Copine-5

1

1

High-throughput

0.536

High

1205819

HM20A
High mobility group protein 20A

1

10

High-throughput

0.536

High

1205830

TCF20
Transcription factor 20

1

1

High-throughput

0.536

High

1205833

SALL4
Sal-like protein 4

1

6

High-throughput

0.536

High

831472

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.527

High

1149207

K1C40
Keratin, type I cytoskeletal 40

1

2

High-throughput

0.523

High

311580

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.513

High

412252

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.513

High

452830

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

968262

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

0

High-throughput

0.513

High

986938

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

1133733

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.513

High

1198616

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.513

High

1205770

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.513

High

1205786

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.513

High

1205793

INT12
Integrator complex subunit 12

1

0

High-throughput

0.513

High

1205799

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

1205801

CCNL2
Cyclin-L2

1

0

High-throughput

0.513

High

1205805

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

1087039

H2A2C
Histone H2A type 2-C

1

3

Small-scale

0.501

High

1205792

STMN2
Stathmin-2

1

1

High-throughput

0.489

High

1205790

CBP
CREB-binding protein

1

8

Small-scale

0.481

High

158821

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.479

High

179710

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

182817

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

198015

PHF1
PHD finger protein 1

1

3

High-throughput

0.479

High

227959

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

229432

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

13

High-throughput

0.479

High

257804

SIN3B
Paired amphipathic helix protein Sin3b

1

5

High-throughput

0.479

High

260926

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.479

High

265221

SAP30
Histone deacetylase complex subunit SAP30

1

1

High-throughput

0.479

High

268160

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

279806

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

3

Small-scale

0.479

High

294994

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

303342

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

312074

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

Small-scale

0.479

High

374487

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

377457

GCR
Glucocorticoid receptor

1

6

High-throughput

0.479

High

387042

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

486927

MYBB
Myb-related protein B

1

2

High-throughput

0.479

High

553112

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

555533

H2AX
Histone H2AX

1

5

High-throughput

0.479

High

569856

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

596782

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

631490

BRD2
Bromodomain-containing protein 2

1

7

High-throughput

0.479

High

651613

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

658700

SMCA1
Probable global transcription activator SNF2L1

1

13

High-throughput

0.479

High

668805

PML
Protein PML

1

1

High-throughput

0.479

High

707680

H2B1B
Histone H2B type 1-B

1

4

High-throughput

0.479

High

720854

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

727773

SOX5
Transcription factor SOX-5

1

12

High-throughput

0.479

High

727890

SOX6
Transcription factor SOX-6

1

15

High-throughput

0.479

High

802453

ATRX
Transcriptional regulator ATRX

1

12

Small-scale

0.479

High

824164

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

828290

CENPA
Histone H3-like centromeric protein A

1

5

High-throughput

0.479

High

881218

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.479

High

884197

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

918496

H2B1C
Histone H2B type 1-C/E/F/G/I

1

4

High-throughput

0.479

High

931716

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

952449

H33
Histone H3.3

1

5

High-throughput

0.479

High

964365

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

976476

ERCC6
DNA excision repair protein ERCC-6

1

15

Small-scale

0.479

High

1017320

BPTF
Nucleosome-remodeling factor subunit BPTF

1

18

High-throughput

0.479

High

1024486

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.479

High

1024566

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.479

High

1032499

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.479

High

1035252

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

High-throughput

0.479

High

1061763

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

15

High-throughput

0.479

High

1070737

RBBP5
Retinoblastoma-binding protein 5

1

2

High-throughput

0.479

High

1117666

ARI4B
AT-rich interactive domain-containing protein 4B

1

3

High-throughput

0.479

High

1119819

LIN52
Protein lin-52 homolog

1

1

High-throughput

0.479

High

1129625

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

3

High-throughput

0.479

High

1137027

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

1188519

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1205097

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

2

Small-scale

0.479

High

1205771

BAP18
Chromatin complexes subunit BAP18

1

1

High-throughput

0.479

High

1205772

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1205774

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.479

High

1205775

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

1205776

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

3

Small-scale

0.479

High

1205777

CSK23
Casein kinase II subunit alpha 3

1

5

High-throughput

0.479

High

1205778

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1205782

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1205789

REQU
Zinc finger protein ubi-d4

1

8

High-throughput

0.479

High

1205791

KAT2B
Histone acetyltransferase KAT2B

1

9

Small-scale

0.479

High

1205794

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

1205795

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

1205798

PWP2A
PWWP domain-containing protein 2A

1

1

High-throughput

0.479

High

1205800

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

1205802

SIN3A
Paired amphipathic helix protein Sin3a

1

5

High-throughput

0.479

High

1205804

TBX5
T-box transcription factor TBX5

1

3

High-throughput

0.479

High

1205808

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1205812

SP130
Histone deacetylase complex subunit SAP130

1

4

High-throughput

0.479

High

1205813

BC11A
B-cell lymphoma/leukemia 11A

1

3

High-throughput

0.479

High

1205816

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

3

High-throughput

0.479

High

1205817

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.479

High

1205823

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1205824

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1205826

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

13

High-throughput

0.479

High

1205829

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1205834

IKZF3
Zinc finger protein Aiolos

1

3

High-throughput

0.479

High

1205837

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.479

High

1205838

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

1205840

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.479

High

1205841

KLF12
Krueppel-like factor 12

1

2

High-throughput

0.479

High

995011

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.470

High

214311

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.460

High

253992

MTG16
Protein CBFA2T3

1

0

High-throughput

0.460

High

122867

MEN1
Menin

1

0

High-throughput

0.458

High

523862

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

656270

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

959521

VIGLN
Vigilin

1

0

High-throughput

0.458

High

961183

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1064460

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1184198

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1205781

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1205807

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1205811

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1205820

ANLN
Anillin

1

0

High-throughput

0.458

High

1205822

NLE1
Notchless protein homolog 1

1

0

High-throughput

0.458

High

1205835

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.458

High

1205839

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

402217

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

1039668

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.445

High

1205803

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.445

High

1205825

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

932240

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.437

High

1146585

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.437

High

1170670

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1205814

FBX44
F-box only protein 44

1

1

Small-scale

0.437

High

1205815

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1205831

HMGX4
HMG domain-containing protein 4

1

12

High-throughput

0.437

High

321120

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

1130286

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.407

High

618659

IF4B
Eukaryotic translation initiation factor 4B

2

0

High-throughput

0.313

High

1205769

ARHGJ
Rho guanine nucleotide exchange factor 19

2

0

High-throughput

0.298

High

224981

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

350313

RASK
GTPase KRas

1

0

High-throughput

0.279

Low

515895

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

814095

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.279

Low

1205796

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.279

Low

255902

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

1205810

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.249

Low

331040

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024