Protein: EZ
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)

Gene: EZ, E(z)
Organism: Drosophila melanogaster
Interactions: 43
UniProt ID: P42124

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

837312

ESC
Polycomb protein esc

25

20

Small-scale

0.991

High

837322

SUZ12
Polycomb protein Su(z)12

10

10

Small-scale

0.975

High

837316

CAF1
Chromatin assembly factor 1 p55 subunit

8

20

Small-scale

0.962

High

381695

H3
Histone H3

3

20

Small-scale

0.849

High

837308

EZ
Histone-lysine N-methyltransferase E(z)

2

18

Small-scale

0.768

High

837332

Q9VKD5
Polycomb protein esc

2

20

Small-scale

0.754

High

837314

PCL
Polycomb protein Pcl

7

20

Small-scale

0.752

High

837320

HDAC1
Histone deacetylase HDAC1

3

20

Small-scale

0.685

High

837319

PHO
Polycomb protein PHO

3

11

Small-scale

0.661

High

837335

JARD2
Jumonji, AT rich interactive domain protein 2

3

13

Small-scale

0.633

High

837309

H2A
Histone H2A

1

14

Small-scale

0.618

High

831794

CORTO
Centrosomal and chromosomal factor

2

0

Small-scale

0.605

High

426637

HP1
Heterochromatin protein 1

2

20

Small-scale

0.595

High

837327

SAP18
Histone deacetylase complex subunit SAP18

1

2

Small-scale

0.586

High

837321

Q95SW6
SD02661p

1

16

Small-scale

0.536

High

837337

Q9W3D5
LD20420p

1

13

High-throughput

0.508

High

837326

INO80
Chromatin-remodeling ATPase INO80

1

19

High-throughput

0.484

High

384978

HSP27
Heat shock protein 27

1

3

Small-scale

0.479

High

683672

PC
Polycomb group protein Pc

1

20

Small-scale

0.479

High

837310

GAGA
Transcription activator GAGA

1

11

Small-scale

0.479

High

837315

RBF
Retinoblastoma family protein

1

8

Small-scale

0.479

High

837318

JING
Zinc finger protein jing

1

10

Small-scale

0.479

High

837324

ASX
Polycomb group protein Asx

1

11

Small-scale

0.479

High

837325

RING1
E3 ubiquitin-protein ligase RING1

1

18

Small-scale

0.479

High

837328

Q9VF04
RE32990p

1

8

Small-scale

0.479

High

837331

SCM
Polycomb protein Scm

1

8

Small-scale

0.479

High

837333

PIWI
Protein piwi

1

3

Small-scale

0.479

High

837334

Q9VP12
Structural maintenance of chromosomes protein 5

1

16

Small-scale

0.479

High

837340

NU931
Nuclear pore complex protein Nup93-1

1

2

Small-scale

0.479

High

444074

TBA1
Tubulin alpha-1 chain

1

8

Small-scale

0.445

High

538229

HSP7D
Heat shock 70 kDa protein cognate 4

1

3

Small-scale

0.445

High

837311

Q24113
Protein no-on-transient A

1

9

Small-scale

0.445

High

837323

JIL1
Chromosomal serine/threonine-protein kinase JIL-1

1

6

High-throughput

0.445

High

837330

Q9VH81
protein-serine/threonine phosphatase

1

6

High-throughput

0.445

High

837338

Q9W3M7
RNA helicase

1

7

Small-scale

0.445

High

837339

Q9W542
LD07342p

1

2

High-throughput

0.445

High

837329

Q9VFE7
Nuclear pore protein

1

2

Small-scale

0.437

High

831902

PEP
Zinc finger protein on ecdysone puffs

1

0

Small-scale

0.426

High

837313

LACH
Lachesin

1

1

High-throughput

0.407

High

837317

Q7JQF6
HL05804p

1

1

High-throughput

0.407

High

304347

O76874
SD17974p

1

0

High-throughput

0.232

Low

837336

Q9VX17
LD36024p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025