Protein: BCL2
Apoptosis regulator Bcl-2

Gene: BCL2
Organism: Homo sapiens
Interactions: 140
UniProt ID: P10415

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000209 - protein polyubiquitination
GO:0001503 - ossification
GO:0001541 - ovarian follicle development
GO:0001656 - metanephros development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

489419

BECN1
Beclin-1

53

8

Small-scale

0.996

High

489401

BAX
Apoptosis regulator BAX

25

17

Small-scale

0.990

High

206715

B2L11
Bcl-2-like protein 11

18

17

Small-scale

0.987

High

489443

BAD
Bcl2-associated agonist of cell death

12

8

Small-scale

0.982

High

385972

P53
Cellular tumor antigen p53

8

9

Small-scale

0.975

High

489391

BID
BH3-interacting domain death agonist

8

10

Small-scale

0.963

High

489402

B2CL1
Bcl-2-like protein 1

6

17

Small-scale

0.946

High

489426

BAK
Bcl-2 homologous antagonist/killer

6

17

Small-scale

0.930

High

489454

BBC3
Bcl-2-binding component 3, isoforms 1/2

5

7

Small-scale

0.915

High

489415

APR
Phorbol-12-myristate-13-acetate-induced protein 1

3

7

Small-scale

0.861

High

489365

BCL2
Apoptosis regulator Bcl-2

3

17

Small-scale

0.847

High

489414

ASPP2
Apoptosis-stimulating of p53 protein 2

2

4

Small-scale

0.839

High

489448

BMF
Bcl-2-modifying factor

3

8

Small-scale

0.814

High

489455

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

2

Small-scale

0.812

High

489418

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

7

2

Small-scale

0.756

High

489462

B2L10
Bcl-2-like protein 10

2

4

Small-scale

0.754

High

489410

BIK
Bcl-2-interacting killer

11

6

Small-scale

0.754

High

489370

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

3

8

Small-scale

0.692

High

489449

BBC3B
Bcl-2-binding component 3, isoforms 3/4

4

5

Small-scale

0.683

High

489409

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

4

5

Small-scale

0.674

High

373583

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

1

Small-scale

0.674

High

489398

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

11

Small-scale

0.664

High

489435

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.656

High

489408

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

3

3

Small-scale

0.651

High

414699

CDK1
Cyclin-dependent kinase 1

3

5

Small-scale

0.646

High

489389

BAP31
B-cell receptor-associated protein 31

2

1

Small-scale

0.641

High

489421

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

2

5

Small-scale

0.634

High

336327

SODC
Superoxide dismutase [Cu-Zn]

2

1

Small-scale

0.634

High

226341

PRKN
E3 ubiquitin-protein ligase parkin

2

7

Small-scale

0.624

High

489385

PSN1
Presenilin-1

2

4

Small-scale

0.620

High

489422

CASP8
Caspase-8

2

8

Small-scale

0.620

High

489450

RAD9A
Cell cycle checkpoint control protein RAD9A

2

2

Small-scale

0.620

High

489463

RTN4
Reticulon-4

2

4

Small-scale

0.620

High

489372

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.615

High

169234

MDM4
Protein Mdm4

2

1

Small-scale

0.611

High

489390

BI1
Bax inhibitor 1

2

4

Small-scale

0.611

High

119879

HRK
Activator of apoptosis harakiri

2

4

Small-scale

0.605

High

489456

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

5

Small-scale

0.597

High

225175

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

2

5

Small-scale

0.595

High

489411

SQSTM
Sequestosome-1

2

1

Small-scale

0.595

High

489403

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

16

Small-scale

0.590

High

489452

BAG1
BAG family molecular chaperone regulator 1

2

1

Small-scale

0.586

High

489367

CEBPB
CCAAT/enhancer-binding protein beta

2

4

Small-scale

0.584

High

489405

PP2BA
Protein phosphatase 3 catalytic subunit alpha

2

13

Small-scale

0.584

High

489428

HIF1A
Hypoxia-inducible factor 1-alpha

2

5

Small-scale

0.584

High

489439

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

1

Small-scale

0.578

High

489425

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

0

Small-scale

0.577

High

489406

PPID
Peptidyl-prolyl cis-trans isomerase D

1

2

Small-scale

0.573

High

489383

MK08
Mitogen-activated protein kinase 8

1

13

Small-scale

0.569

High

489379

BRCA1
Breast cancer type 1 susceptibility protein

1

3

Small-scale

0.561

High

489404

PPARA
Peroxisome proliferator-activated receptor alpha

1

5

Small-scale

0.561

High

431460

HS90A
Heat shock protein HSP 90-alpha

2

0

Small-scale

0.559

High

198178

SEPT4
Septin-4

1

1

Small-scale

0.552

High

489433

BNIPL
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

1

3

Small-scale

0.552

High

489464

AVEN
Cell death regulator Aven

1

1

Small-scale

0.552

High

489468

BFAR
Bifunctional apoptosis regulator

1

4

Small-scale

0.552

High

489427

SMN
Survival motor neuron protein

1

0

Small-scale

0.549

High

489465

SPHK2
Sphingosine kinase 2

1

0

Small-scale

0.537

High

489399

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.536

High

483415

RGPD2
RANBP2-like and GRIP domain-containing protein 2

1

1

High-throughput

0.536

High

489376

ABCD1
ATP-binding cassette sub-family D member 1

1

1

High-throughput

0.536

High

489400

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.536

High

489429

MBRL
Membralin

1

1

High-throughput

0.536

High

489451

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

6

High-throughput

0.536

High

489457

MFF
Mitochondrial fission factor

1

1

High-throughput

0.536

High

489459

GHITM
Growth hormone-inducible transmembrane protein

1

4

High-throughput

0.536

High

175416

SIVA
Apoptosis regulatory protein Siva

1

2

Small-scale

0.527

High

489369

VDAC1
Voltage-dependent anion-selective channel protein 1

1

8

Small-scale

0.515

High

489378

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

11

High-throughput

0.515

High

489393

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

11

High-throughput

0.515

High

489394

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

11

High-throughput

0.515

High

489458

SPNS1
Protein spinster homolog 1

1

1

Small-scale

0.515

High

393994

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

489366

CAN2
Calpain-2 catalytic subunit

1

0

Small-scale

0.513

High

437176

MDR1
ATP-dependent translocase ABCB1

1

0

High-throughput

0.513

High

489382

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.513

High

489392

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.513

High

489431

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.513

High

489440

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.513

High

489466

MTMR4
Myotubularin-related protein 4

1

0

High-throughput

0.513

High

489460

B2L12
Bcl-2-like protein 12

1

2

Small-scale

0.508

High

488056

RRAS
Ras-related protein R-Ras

1

7

Small-scale

0.504

High

455020

PARP1
Poly [ADP-ribose] polymerase 1

1

3

Small-scale

0.501

High

489380

CASP3
Caspase-3

1

8

Small-scale

0.501

High

489384

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

1

14

Small-scale

0.501

High

489388

BLK
Tyrosine-protein kinase Blk

1

3

Small-scale

0.501

High

489395

CANB1
Calcineurin subunit B type 1

1

1

Small-scale

0.501

High

489407

SEC20
Vesicle transport protein SEC20

1

1

Small-scale

0.501

High

489430

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

Small-scale

0.501

High

489446

RN183
E3 ubiquitin-protein ligase RNF183

1

1

Small-scale

0.501

High

236605

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

1

0

Small-scale

0.493

High

403581

AP2A
Transcription factor AP-2-alpha

1

0

Small-scale

0.493

High

489434

GLT10
Polypeptide N-acetylgalactosaminyltransferase 10

1

1

High-throughput

0.489

High

489416

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

1

Small-scale

0.481

High

489436

MEX3D
RNA-binding protein MEX3D

1

1

Small-scale

0.481

High

489467

BCLF1
Bcl-2-associated transcription factor 1

1

0

Small-scale

0.479

High

158379

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

3

Small-scale

0.479

High

167453

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

3

Small-scale

0.479

High

204108

KLF4
Krueppel-like factor 4

1

1

Small-scale

0.479

High

296690

ATG12
Ubiquitin-like protein ATG12

1

1

Small-scale

0.479

High

306970

RTN3
Reticulon-3

1

3

Small-scale

0.479

High

324191

BAG3
BAG family molecular chaperone regulator 3

1

5

Small-scale

0.479

High

345776

MYC
Myc proto-oncogene protein

1

1

Small-scale

0.479

High

349821

RASK
GTPase KRas

1

6

Small-scale

0.479

High

358960

CRYAB
Alpha-crystallin B chain

1

6

Small-scale

0.479

High

377042

GCR
Glucocorticoid receptor

1

6

Small-scale

0.479

High

489371

CDK2
Cyclin-dependent kinase 2

1

5

Small-scale

0.479

High

489373

PML
Protein PML

1

2

Small-scale

0.479

High

489377

IRS1
Insulin receptor substrate 1

1

3

Small-scale

0.479

High

489386

PSN2
Presenilin-2

1

4

Small-scale

0.479

High

489387

SPB8
Serpin B8

1

2

Small-scale

0.479

High

489396

DYL1
Dynein light chain 1, cytoplasmic

1

4

Small-scale

0.479

High

489397

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.479

High

489412

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.479

High

489413

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

489417

KEAP1
Kelch-like ECH-associated protein 1

1

1

Small-scale

0.479

High

489420

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

5

Small-scale

0.479

High

489438

BLID
BH3-like motif-containing cell death inducer

1

1

Small-scale

0.479

High

489441

PRUN2
Protein prune homolog 2

1

3

Small-scale

0.479

High

489442

NR4A3
Nuclear receptor subfamily 4 group A member 3

1

5

Small-scale

0.479

High

489444

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

1

Small-scale

0.479

High

489445

MOAP1
Modulator of apoptosis 1

1

2

Small-scale

0.479

High

489447

GIMA5
GTPase IMAP family member 5

1

5

Small-scale

0.479

High

489453

LFG2
Protein lifeguard 2

1

4

Small-scale

0.479

High

489470

IRS2
Insulin receptor substrate 2

1

3

Small-scale

0.479

High

489471

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.479

High

414138

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

485041

GLI2
Zinc finger protein GLI2

1

0

Small-scale

0.458

High

489368

LEG3
Galectin-3

1

0

Small-scale

0.458

High

489375

METK2
S-adenosylmethionine synthase isoform type-2

1

0

Small-scale

0.458

High

489381

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

Small-scale

0.458

High

489423

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.458

High

489424

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

489461

TPIP1
p53-regulated apoptosis-inducing protein 1

1

0

Small-scale

0.458

High

489469

ITM2B
Integral membrane protein 2B

1

0

Small-scale

0.458

High

489374

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

3

Small-scale

0.457

High

489437

VRK2
Serine/threonine-protein kinase VRK2

1

2

Small-scale

0.457

High

489432

BOP
Protein Bop

1

6

Small-scale

0.445

High

68334

BECN2
Beclin-2

1

8

Small-scale

0.437

High


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Last updated: 15 Jul 2024