Protein: CAN2
Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)

Gene: CAN2, CAPN2
Organism: Homo sapiens
Interactions: 114
UniProt ID: P17655

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001666 - response to hypoxia
GO:0001824 - blastocyst development
GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

427838

CAN1
Calpain-1 catalytic subunit

2

15

High-throughput

0.811

High

568946

ICAL
Calpastatin

2

5

Small-scale

0.789

High

568980

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

1

High-throughput

0.754

High

568948

MK01
Mitogen-activated protein kinase 1

1

2

Small-scale

0.735

High

569002

KCTD7
BTB/POZ domain-containing protein KCTD7

1

10

Small-scale

0.724

High

70648

MYO9A
Unconventional myosin-IXa

1

10

High-throughput

0.691

High

569022

E2AK4
eIF-2-alpha kinase GCN2

1

7

High-throughput

0.691

High

385837

CPNS1
Calpain small subunit 1

4

15

Small-scale

0.686

High

528495

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.662

High

496249

TAU
Microtubule-associated protein tau

2

7

Small-scale

0.619

High

568957

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.618

High

568960

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.618

High

568945

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

1

Small-scale

0.602

High

568961

ATX3
Ataxin-3

2

3

Small-scale

0.602

High

568950

LSP1
Lymphocyte-specific protein 1

2

0

High-throughput

0.602

High

226458

PRKN
E3 ubiquitin-protein ligase parkin

2

11

High-throughput

0.584

High

568993

ZDH17
Palmitoyltransferase ZDHHC17

1

2

High-throughput

0.582

High

568975

CAV1
Caveolin-1

2

2

High-throughput

0.571

High

569011

ATG5
Autophagy protein 5

1

1

Small-scale

0.569

High

569001

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

Small-scale

0.561

High

569008

ZFY21
Zinc finger FYVE domain-containing protein 21

1

1

Small-scale

0.561

High

215517

CF410
Cilia- and flagella-associated protein 410

1

2

High-throughput

0.536

High

272484

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.536

High

568953

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.536

High

568954

FNTA
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

1

1

High-throughput

0.536

High

568955

FNTB
Protein farnesyltransferase subunit beta

1

3

High-throughput

0.536

High

568958

JAK3
Tyrosine-protein kinase JAK3

1

1

High-throughput

0.536

High

568959

STAT2
Signal transducer and activator of transcription 2

1

3

High-throughput

0.536

High

568962

PMS1
PMS1 protein homolog 1

1

1

High-throughput

0.536

High

568972

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.536

High

568976

DMWD
Dystrophia myotonica WD repeat-containing protein

1

2

High-throughput

0.536

High

568988

CD109
CD109 antigen

1

1

High-throughput

0.536

High

568995

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

High-throughput

0.536

High

569003

DOCK7
Dedicator of cytokinesis protein 7

1

4

High-throughput

0.536

High

569009

AFG2B
ATPase family gene 2 protein homolog B

1

1

High-throughput

0.536

High

569015

DIAP3
Protein diaphanous homolog 3

1

4

High-throughput

0.536

High

569019

FMN2
Formin-2

1

1

High-throughput

0.536

High

569026

MCM8
DNA helicase MCM8

1

1

High-throughput

0.536

High

569029

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

2

High-throughput

0.536

High

569030

WDR37
WD repeat-containing protein 37

1

1

High-throughput

0.536

High

568952

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

569032

LOXL2
Lysyl oxidase homolog 2

1

1

Small-scale

0.515

High

423136

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.515

High

527285

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

568963

CASP6
Caspase-6

1

2

High-throughput

0.515

High

568967

RAN
GTP-binding nuclear protein Ran

1

3

High-throughput

0.515

High

489366

BCL2
Apoptosis regulator Bcl-2

1

0

Small-scale

0.513

High

128806

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

155985

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

200975

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.513

High

508813

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

549085

GNS
N-acetylglucosamine-6-sulfatase

1

0

High-throughput

0.513

High

568944

EGLN
Endoglin

1

0

High-throughput

0.513

High

568968

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

568983

ERC6L
DNA excision repair protein ERCC-6-like

1

0

High-throughput

0.513

High

568986

TUT4
Terminal uridylyltransferase 4

1

0

High-throughput

0.513

High

568991

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.513

High

568996

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

569007

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.513

High

569016

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.513

High

569031

MTO1
Protein MTO1 homolog, mitochondrial

1

0

High-throughput

0.513

High

568982

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

2

Small-scale

0.501

High

569023

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

233201

NUPR1
Nuclear protein 1

1

0

High-throughput

0.493

High

568965

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.493

High

568985

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

1

High-throughput

0.489

High

568990

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

1

1

High-throughput

0.489

High

568964

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.480

High

569014

TENS1
Tensin-1

1

0

Small-scale

0.480

High

243892

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

345862

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

384222

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

453130

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

568947

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

568949

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

1

Small-scale

0.479

High

568956

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

Small-scale

0.479

High

568966

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

568977

TP4A2
Protein tyrosine phosphatase type IVA 2

1

1

High-throughput

0.479

High

568979

CUL3
Cullin-3

1

7

Small-scale

0.479

High

568981

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

568984

DUS28
Dual specificity phosphatase 28

1

2

High-throughput

0.479

High

568987

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

568989

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

568998

DUS19
Dual specificity protein phosphatase 19

1

2

High-throughput

0.479

High

569000

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.479

High

569005

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

569012

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

569013

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

569017

FXL12
F-box/LRR-repeat protein 12

1

1

Small-scale

0.479

High

569024

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

569028

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

263507

PR40A
Pre-mRNA-processing factor 40 homolog A

1

6

High-throughput

0.470

High

455068

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

503392

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

568969

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

568970

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.458

High

568971

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.458

High

568973

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

568992

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

568999

DNS2B
Deoxyribonuclease-2-beta

1

0

High-throughput

0.458

High

569020

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

569004

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

126221

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

1

High-throughput

0.437

High

568951

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

569006

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

569018

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

3

0

High-throughput

0.347

High

568974

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

568978

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

568994

FAM9C
Protein FAM9C

1

0

High-throughput

0.279

Low

568997

WDR36
WD repeat-containing protein 36

1

0

High-throughput

0.279

Low

569010

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

0

High-throughput

0.279

Low

569025

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.279

Low

569027

TASOR
Protein TASOR

1

0

High-throughput

0.279

Low

569021

Q9P1I4
PRO0786

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024