Protein: APAF
Apoptotic protease-activating factor 1 (APAF-1)

Gene: APAF, APAF1
Organism: Homo sapiens
Interactions: 82
UniProt ID: O14727

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0001666 - response to hypoxia
GO:0001822 - kidney development
GO:0001843 - neural tube closure
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

152863

CASP9
Caspase-9

21

5

Small-scale

0.988

High

152888

WDFY3
WD repeat and FYVE domain-containing protein 3

2

15

High-throughput

0.811

High

152870

CYC
Cytochrome c

3

0

Small-scale

0.803

High

152869

XIAP
E3 ubiquitin-protein ligase XIAP

2

8

Small-scale

0.754

High

152872

B2CL1
Bcl-2-like protein 1

2

1

Small-scale

0.754

High

152912

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

4

High-throughput

0.691

High

152918

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

2

High-throughput

0.691

High

152855

HSP74
Heat shock 70 kDa protein 4

3

9

Small-scale

0.674

High

152902

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.656

High

152906

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

0

Small-scale

0.656

High

152901

OMD
Osteomodulin

2

1

High-throughput

0.628

High

152907

DNAI2
Dynein axonemal intermediate chain 2

1

18

High-throughput

0.618

High

152845

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

152859

CASP4
Caspase-4

1

5

Small-scale

0.618

High

152899

DNJC7
DnaJ homolog subfamily C member 7

1

13

High-throughput

0.618

High

152908

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

152913

B2L10
Bcl-2-like protein 10

1

0

Small-scale

0.586

High

152898

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.585

High

152844

PRKY
Putative serine/threonine-protein kinase PRKY

1

4

High-throughput

0.575

High

152885

DEFI8
Differentially expressed in FDCP 8 homolog

2

5

High-throughput

0.574

High

152851

HS90A
Heat shock protein HSP 90-alpha

2

8

Small-scale

0.563

High

152857

CASP3
Caspase-3

2

5

Small-scale

0.563

High

152864

NU107
Nuclear pore complex protein Nup107

1

2

Small-scale

0.561

High

152887

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

152896

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

Small-scale

0.549

High

152866

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.546

High

71030

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

13

High-throughput

0.536

High

149798

RFXK
DNA-binding protein RFXANK

1

7

High-throughput

0.536

High

152841

PI51B
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

1

3

High-throughput

0.536

High

152849

LGI1
Leucine-rich glioma-inactivated protein 1

1

1

High-throughput

0.536

High

152858

LEG7
Galectin-7

1

4

High-throughput

0.536

High

152871

PPARD
Peroxisome proliferator-activated receptor delta

1

20

High-throughput

0.536

High

152878

IKBB
NF-kappa-B inhibitor beta

1

5

High-throughput

0.536

High

152882

EFMT2
EEF1A lysine methyltransferase 2

1

1

High-throughput

0.536

High

152884

LYPD4
Ly6/PLAUR domain-containing protein 4

1

2

High-throughput

0.536

High

152895

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.536

High

152897

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.536

High

152900

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.536

High

152903

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.536

High

152904

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

152910

KLK15
Kallikrein-15

1

3

High-throughput

0.536

High

152915

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

152917

TRI35
E3 ubiquitin-protein ligase TRIM35

1

1

High-throughput

0.536

High

152848

RL1D1
Ribosomal L1 domain-containing protein 1

1

12

High-throughput

0.515

High

152879

H31T
Histone H3.1t

1

9

High-throughput

0.515

High

152842

RA51B
DNA repair protein RAD51 homolog 2

1

0

High-throughput

0.513

High

152846

EVI5
Ecotropic viral integration site 5 protein homolog

1

0

High-throughput

0.513

High

152861

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.513

High

152880

RPEL1
Ribulose-phosphate 3-epimerase-like protein 1

1

0

High-throughput

0.513

High

152883

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

152893

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

152905

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

152911

BAFL
Barrier-to-autointegration factor-like protein

1

0

High-throughput

0.513

High

152914

AVEN
Cell death regulator Aven

1

0

Small-scale

0.493

High

152847

CIB2
Calcium and integrin-binding family member 2

1

4

High-throughput

0.489

High

152854

CRBB3
Beta-crystallin B3

1

2

High-throughput

0.489

High

152860

ARL4D
ADP-ribosylation factor-like protein 4D

1

8

High-throughput

0.489

High

152862

CRBA4
Beta-crystallin A4

1

2

High-throughput

0.489

High

152881

UROL1
Uromodulin-like 1

1

2

High-throughput

0.489

High

152889

CLASR
CLK4-associating serine/arginine rich protein

1

1

High-throughput

0.489

High

152916

AT7L1
Ataxin-7-like protein 1

1

9

High-throughput

0.489

High

124340

HIP1
Huntingtin-interacting protein 1

1

4

Small-scale

0.479

High

126976

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

5

High-throughput

0.479

High

152850

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

152853

ENPL
Endoplasmin

1

8

Small-scale

0.479

High

152856

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

152867

1433E
14-3-3 protein epsilon

1

2

Small-scale

0.479

High

152868

RHOG
Rho-related GTP-binding protein RhoG

1

12

High-throughput

0.479

High

152873

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

152874

SQSTM
Sequestosome-1

1

3

Small-scale

0.479

High

152875

CUL3
Cullin-3

1

20

High-throughput

0.479

High

152876

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

152877

CASP8
Caspase-8

1

5

Small-scale

0.479

High

152909

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

152843

TRIA1
TP53-regulated inhibitor of apoptosis 1

1

0

Small-scale

0.458

High

152892

GMCL2
Germ cell-less protein-like 2

1

4

High-throughput

0.445

High

152852

TOP1
DNA topoisomerase 1

1

2

Small-scale

0.408

High

152886

PKHG7
Pleckstrin homology domain-containing family G member 7

1

17

High-throughput

0.407

High

152891

GG6L2
Golgin subfamily A member 6-like protein 2

1

20

High-throughput

0.407

High

152890

ENDOV
Endonuclease V

3

0

High-throughput

0.347

High

152865

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.279

Low

152894

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024