Protein: IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)

Gene: IKKA, CHUK
Organism: Homo sapiens
Interactions: 238
UniProt ID: O15111

Gene Ontology (top 5):
GO:0003009 - skeletal muscle contraction
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

167642

NEMO
NF-kappa-B essential modulator

70

20

Small-scale

0.997

High

167475

IKBA
NF-kappa-B inhibitor alpha

66

20

Small-scale

0.997

High

158345

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

39

18

Small-scale

0.995

High

167603

M3K14
Mitogen-activated protein kinase kinase kinase 14

21

20

Small-scale

0.991

High

167555

CDC37
Hsp90 co-chaperone Cdc37

8

14

Small-scale

0.974

High

167416

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

10

18

Small-scale

0.971

High

167420

M3K7
Mitogen-activated protein kinase kinase kinase 7

9

11

Small-scale

0.965

High

167469

NFKB1
Nuclear factor NF-kappa-B p105 subunit

5

20

Small-scale

0.935

High

167481

AKT1
RAC-alpha serine/threonine-protein kinase

5

20

Small-scale

0.933

High

167534

M3K1
Mitogen-activated protein kinase kinase kinase 1

5

20

Small-scale

0.926

High

167446

HS90A
Heat shock protein HSP 90-alpha

5

20

Small-scale

0.922

High

167551

IKBB
NF-kappa-B inhibitor beta

5

20

Small-scale

0.920

High

167522

NFKB2
Nuclear factor NF-kappa-B p100 subunit

5

20

Small-scale

0.909

High

167538

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

4

17

High-throughput

0.900

High

167526

KPCT
Protein kinase C theta type

4

20

Small-scale

0.873

High

167541

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

4

19

Small-scale

0.873

High

167468

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

3

20

Small-scale

0.839

High

167547

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

2

18

Small-scale

0.799

High

167449

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

167457

SRC
Proto-oncogene tyrosine-protein kinase Src

2

16

Small-scale

0.789

High

167500

IRAK1
Interleukin-1 receptor-associated kinase 1

2

7

Small-scale

0.776

High

167556

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

8

Small-scale

0.771

High

167525

TF65
Transcription factor p65

11

20

Small-scale

0.756

High

167485

IRS1
Insulin receptor substrate 1

1

10

Small-scale

0.747

High

167492

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

20

Small-scale

0.747

High

167563

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

12

Small-scale

0.747

High

167518

SRPK2
SRSF protein kinase 2

1

15

High-throughput

0.735

High

167601

SRPK1
SRSF protein kinase 1

1

20

High-throughput

0.735

High

167531

TRAF2
TNF receptor-associated factor 2

6

20

Small-scale

0.730

High

167467

TNR1A
Tumor necrosis factor receptor superfamily member 1A

6

18

Small-scale

0.729

High

167456

PSG1
Pregnancy-specific beta-1-glycoprotein 1

2

6

High-throughput

0.726

High

167450

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

14

Small-scale

0.724

High

167465

KPCA
Protein kinase C alpha type

1

20

Small-scale

0.724

High

167482

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.724

High

167493

KPCI
Protein kinase C iota type

1

20

Small-scale

0.724

High

167528

KPCD
Protein kinase C delta type

1

20

Small-scale

0.724

High

167643

NCOA3
Nuclear receptor coactivator 3

4

7

Small-scale

0.704

High

167480

EPHA3
Ephrin type-A receptor 3

1

11

High-throughput

0.691

High

167501

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

167524

KPCE
Protein kinase C epsilon type

1

20

High-throughput

0.691

High

167533

FADD
FAS-associated death domain protein

1

9

High-throughput

0.691

High

167557

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

15

High-throughput

0.691

High

167578

NLRC5
Protein NLRC5

1

15

Small-scale

0.690

High

167590

CBP
CREB-binding protein

3

15

Small-scale

0.687

High

167437

TNFA
Tumor necrosis factor

4

6

Small-scale

0.676

High

167436

MYC
Myc proto-oncogene protein

3

8

Small-scale

0.675

High

167593

CSN5
COP9 signalosome complex subunit 5

3

8

Small-scale

0.667

High

160254

AURKA
Aurora kinase A

1

19

Small-scale

0.665

High

167428

PPM1B
Protein phosphatase 1B

1

20

Small-scale

0.665

High

167549

CASP8
Caspase-8

1

8

Small-scale

0.665

High

167623

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

13

Small-scale

0.665

High

167629

TPX2
Targeting protein for Xklp2

1

7

Small-scale

0.665

High

167484

CTNB1
Catenin beta-1

2

6

Small-scale

0.656

High

167435

BCL10
B-cell lymphoma/leukemia 10

3

2

Small-scale

0.651

High

167421

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

10

Small-scale

0.647

High

167451

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

14

High-throughput

0.647

High

167471

BCL3
B-cell lymphoma 3 protein

1

20

Small-scale

0.647

High

167497

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

10

Small-scale

0.647

High

167516

CSK21
Casein kinase II subunit alpha

1

13

Small-scale

0.647

High

167627

TBK1
Serine/threonine-protein kinase TBK1

1

17

Small-scale

0.647

High

167644

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

20

Small-scale

0.647

High

167639

TRAF6
TNF receptor-associated factor 6

3

20

Small-scale

0.640

High

167585

TNIP2
TNFAIP3-interacting protein 2

2

2

Small-scale

0.639

High

167494

MTOR
Serine/threonine-protein kinase mTOR

2

20

Small-scale

0.628

High

167417

P73
Tumor protein p73

2

10

Small-scale

0.624

High

167592

TANK
TRAF family member-associated NF-kappa-B activator

2

5

Small-scale

0.621

High

71034

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

8

High-throughput

0.618

High

167635

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

5

High-throughput

0.618

High

121549

IKBE
NF-kappa-B inhibitor epsilon

1

20

High-throughput

0.618

High

167425

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

167430

TRIO
Triple functional domain protein

1

17

Small-scale

0.618

High

167431

RNF8
E3 ubiquitin-protein ligase RNF8

1

20

Small-scale

0.618

High

167433

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.618

High

167441

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

167448

GLI1
Zinc finger protein GLI1

1

5

Small-scale

0.618

High

167461

VAV
Proto-oncogene vav

1

5

Small-scale

0.618

High

167466

ML12A
Myosin regulatory light chain 12A

1

17

High-throughput

0.618

High

167473

CCND1
G1/S-specific cyclin-D1

1

14

Small-scale

0.618

High

167478

DUS1
Dual specificity protein phosphatase 1

1

6

Small-scale

0.618

High

167491

CCNF
Cyclin-F

1

10

High-throughput

0.618

High

167496

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

20

Small-scale

0.618

High

167498

NOTC1
Neurogenic locus notch homolog protein 1

1

2

Small-scale

0.618

High

167513

ACTG
Actin, cytoplasmic 2

1

12

High-throughput

0.618

High

167548

NBR1
Next to BRCA1 gene 1 protein

1

5

Small-scale

0.618

High

167550

LRC14
Leucine-rich repeat-containing protein 14

1

5

Small-scale

0.618

High

167552

ELAV1
ELAV-like protein 1

1

9

Small-scale

0.618

High

167571

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

167575

NLRX1
NLR family member X1

1

14

Small-scale

0.618

High

167581

RPTOR
Regulatory-associated protein of mTOR

1

16

Small-scale

0.618

High

167587

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

14

Small-scale

0.618

High

167598

NALP4
NACHT, LRR and PYD domains-containing protein 4

1

13

Small-scale

0.618

High

167605

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

20

High-throughput

0.618

High

167429

PIAS1
E3 SUMO-protein ligase PIAS1

3

0

Small-scale

0.613

High

167434

ELP1
Elongator complex protein 1

2

1

Small-scale

0.612

High

167442

P53
Cellular tumor antigen p53

2

10

Small-scale

0.611

High

167483

ARRB2
Beta-arrestin-2

2

5

Small-scale

0.611

High

167515

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

20

Small-scale

0.611

High

167573

MYH14
Myosin-14

2

20

High-throughput

0.611

High

167422

FOXO3
Forkhead box protein O3

1

8

Small-scale

0.608

High

167459

TRI27
Zinc finger protein RFP

1

18

Small-scale

0.608

High

167418

FANCA
Fanconi anemia group A protein

2

2

Small-scale

0.606

High

167641

NCOR2
Nuclear receptor corepressor 2

2

6

Small-scale

0.602

High

167532

TRAF1
TNF receptor-associated factor 1

2

20

Small-scale

0.584

High

167543

CUL1
Cullin-1

2

15

Small-scale

0.584

High

167546

KEAP1
Kelch-like ECH-associated protein 1

2

5

Small-scale

0.584

High

167574

MAVS
Mitochondrial antiviral-signaling protein

2

7

Small-scale

0.584

High

167424

PRKY
Putative serine/threonine-protein kinase PRKY

1

20

High-throughput

0.575

High

167617

CUED2
CUE domain-containing protein 2

1

2

Small-scale

0.573

High

167537

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

4

Small-scale

0.561

High

167567

RICTR
Rapamycin-insensitive companion of mTOR

1

1

Small-scale

0.561

High

167572

H32
Histone H3.2

1

9

Small-scale

0.561

High

167576

TAXB1
Tax1-binding protein 1

1

20

Small-scale

0.561

High

167613

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

6

Small-scale

0.561

High

167568

SHC4
SHC-transforming protein 4

2

18

High-throughput

0.558

High

167630

ASC
Apoptosis-associated speck-like protein containing a CARD

1

11

Small-scale

0.554

High

167503

TTC3
E3 ubiquitin-protein ligase TTC3

1

17

High-throughput

0.541

High

167509

RL27
Large ribosomal subunit protein eL27

1

2

High-throughput

0.541

High

167529

PAX8
Paired box protein Pax-8

1

4

High-throughput

0.541

High

167517

H31
Histone H3.1

1

9

Small-scale

0.536

High

167519

PRKDC
DNA-dependent protein kinase catalytic subunit

1

19

Small-scale

0.536

High

167458

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

167479

T2EA
General transcription factor IIE subunit 1

1

1

High-throughput

0.536

High

167488

MYH11
Myosin-11

1

20

High-throughput

0.536

High

167559

DREB
Drebrin

1

3

High-throughput

0.536

High

167560

H2A2C
Histone H2A type 2-C

1

9

High-throughput

0.536

High

167579

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

20

Small-scale

0.536

High

167584

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

14

High-throughput

0.536

High

167589

GCN1
Stalled ribosome sensor GCN1

1

20

High-throughput

0.536

High

167595

EFMT3
EEF1A lysine methyltransferase 3

1

9

High-throughput

0.536

High

167602

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.536

High

167604

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.536

High

167611

UBXN6
UBX domain-containing protein 6

1

2

High-throughput

0.536

High

167615

SHRPN
Sharpin

1

3

Small-scale

0.536

High

167618

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.536

High

167626

STAP2
Signal-transducing adaptor protein 2

1

1

Small-scale

0.536

High

167553

SMAD2
Mothers against decapentaplegic homolog 2

1

8

Small-scale

0.534

High

167443

HSPB1
Heat shock protein beta-1

1

6

Small-scale

0.515

High

167460

ETS1
Protein C-ets-1

1

3

Small-scale

0.515

High

167472

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

11

Small-scale

0.515

High

167510

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

Small-scale

0.515

High

167512

RACK1
Small ribosomal subunit protein RACK1

1

10

Small-scale

0.515

High

167520

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.515

High

167419

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

167565

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

167620

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

167562

HECD3
E3 ubiquitin-protein ligase HECTD3

1

20

Small-scale

0.512

High

167426

NCOR1
Nuclear receptor corepressor 1

1

19

Small-scale

0.501

High

167495

HD
Huntingtin

1

10

Small-scale

0.501

High

167508

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

Small-scale

0.501

High

167514

UBC9
SUMO-conjugating enzyme UBC9

1

7

Small-scale

0.501

High

167554

E2F4
Transcription factor E2F4

1

7

Small-scale

0.501

High

167594

IRF7
Interferon regulatory factor 7

1

15

Small-scale

0.501

High

167600

ERBIN
Erbin

1

3

Small-scale

0.501

High

167608

TRAF4
TNF receptor-associated factor 4

1

20

Small-scale

0.501

High

167637

FBW1A
F-box/WD repeat-containing protein 1A

1

19

Small-scale

0.501

High

167477

CALX
Calnexin

1

3

High-throughput

0.489

High

167591

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.489

High

167597

MR1L1
MORF4 family-associated protein 1-like 1

1

1

High-throughput

0.489

High

167606

KCD14
BTB/POZ domain-containing protein KCTD14

1

2

High-throughput

0.489

High

167614

DNAI2
Dynein axonemal intermediate chain 2

1

3

High-throughput

0.489

High

167540

ATR
Serine/threonine-protein kinase ATR

1

19

Small-scale

0.481

High

167607

DCNL5
DCN1-like protein 5

1

0

Small-scale

0.480

High

122117

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

Small-scale

0.479

High

162198

XPO1
Exportin-1

1

10

High-throughput

0.479

High

167423

CIKS
E3 ubiquitin ligase TRAF3IP2

1

5

Small-scale

0.479

High

167427

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

7

Small-scale

0.479

High

167432

MYO1D
Unconventional myosin-Id

1

18

High-throughput

0.479

High

167438

TFR1
Transferrin receptor protein 1

1

2

Small-scale

0.479

High

167439

ESR1
Estrogen receptor

1

17

Small-scale

0.479

High

167440

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.479

High

167444

TPM3
Tropomyosin alpha-3 chain

1

11

High-throughput

0.479

High

167445

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

167447

TNR16
Tumor necrosis factor receptor superfamily member 16

1

18

Small-scale

0.479

High

167452

IL8
Interleukin-8

1

2

Small-scale

0.479

High

167453

BCL2
Apoptosis regulator Bcl-2

1

3

Small-scale

0.479

High

167454

CH60
60 kDa heat shock protein, mitochondrial

1

11

Small-scale

0.479

High

167455

CLUS
Clusterin

1

1

Small-scale

0.479

High

167463

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

167464

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

1

2

High-throughput

0.479

High

167470

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

18

Small-scale

0.479

High

167474

TNR5
Tumor necrosis factor receptor superfamily member 5

1

18

Small-scale

0.479

High

167476

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

167486

MYH9
Myosin-9

1

20

High-throughput

0.479

High

167487

MYH10
Myosin-10

1

20

High-throughput

0.479

High

167489

TNR3
Tumor necrosis factor receptor superfamily member 3

1

18

Small-scale

0.479

High

167490

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

167499

ARRB1
Beta-arrestin-1

1

5

Small-scale

0.479

High

167502

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.479

High

167504

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.479

High

167505

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

167506

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

Small-scale

0.479

High

167507

MYL6
Myosin light polypeptide 6

1

15

High-throughput

0.479

High

167511

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

20

High-throughput

0.479

High

167521

CLH1
Clathrin heavy chain 1

1

5

High-throughput

0.479

High

167523

RELB
Transcription factor RelB

1

20

High-throughput

0.479

High

167527

EF1A2
Elongation factor 1-alpha 2

1

10

High-throughput

0.479

High

167535

SKP2
S-phase kinase-associated protein 2

1

4

Small-scale

0.479

High

167536

ATM
Serine-protein kinase ATM

1

19

Small-scale

0.479

High

167539

BIRC3
Baculoviral IAP repeat-containing protein 3

1

15

Small-scale

0.479

High

167542

IRF5
Interferon regulatory factor 5

1

15

Small-scale

0.479

High

167544

CUL3
Cullin-3

1

15

High-throughput

0.479

High

167545

CUL4A
Cullin-4A

1

15

High-throughput

0.479

High

167558

SMN
Survival motor neuron protein

1

4

Small-scale

0.479

High

167566

TRI40
E3 ubiquitin ligase TRIM40

1

19

Small-scale

0.479

High

167577

COMD7
COMM domain-containing protein 7

1

1

Small-scale

0.479

High

167580

TRI22
E3 ubiquitin-protein ligase TRIM22

1

18

Small-scale

0.479

High

167582

A16L2
Protein Atg16l2

1

12

Small-scale

0.479

High

167583

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.479

High

167588

PYDC1
Pyrin domain-containing protein 1

1

11

Small-scale

0.479

High

167609

LST8
Target of rapamycin complex subunit LST8

1

9

Small-scale

0.479

High

167610

CAR11
Caspase recruitment domain-containing protein 11

1

5

Small-scale

0.479

High

167616

P63
Tumor protein 63

1

10

Small-scale

0.479

High

167619

EGLN3
Prolyl hydroxylase EGLN3

1

7

Small-scale

0.479

High

167624

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

1

Small-scale

0.479

High

167625

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

7

Small-scale

0.479

High

167628

KLH21
Kelch-like protein 21

1

8

Small-scale

0.479

High

167631

SPAT2
Spermatogenesis-associated protein 2

1

1

Small-scale

0.479

High

167632

UBP18
Ubl carboxyl-terminal hydrolase 18

1

14

Small-scale

0.479

High

167633

CHIP
E3 ubiquitin-protein ligase CHIP

1

13

Small-scale

0.479

High

167634

CSN3
COP9 signalosome complex subunit 3

1

8

Small-scale

0.479

High

167636

Q9UQC1
Heat shock protein 72

1

20

High-throughput

0.479

High

167640

MAGD1
Melanoma-associated antigen D1

1

4

Small-scale

0.479

High

167586

TP4AP
Short transient receptor potential channel 4-associated protein

1

1

Small-scale

0.470

High

167569

PKHG7
Pleckstrin homology domain-containing family G member 7

1

13

High-throughput

0.445

High

132371

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

Small-scale

0.437

High

167462

CSF2R
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

1

10

Small-scale

0.437

High

167530

GOGA2
Golgin subfamily A member 2

1

20

High-throughput

0.437

High

167564

RETST
All-trans-retinol 13,14-reductase

1

3

High-throughput

0.437

High

167621

ZDH11
Palmitoyltransferase ZDHHC11

1

1

Small-scale

0.437

High

167638

RNF11
RING finger protein 11

1

6

Small-scale

0.437

High

99738

F5H5M1
SHC adaptor protein 4

1

16

High-throughput

0.407

High

167570

INSY2
Inhibitory synaptic factor 2A

2

0

High-throughput

0.328

High

167599

BBC3B
Bcl-2-binding component 3, isoforms 3/4

1

0

Small-scale

0.292

High

167596

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

167612

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

167622

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

167561

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024