Protein: MELK
Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)

Gene: MELK
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q14680

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004674 - protein serine/threonine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005509 - calcium ion binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

673479

MPIP2
M-phase inducer phosphatase 2

2

1

Small-scale

0.806

High

771188

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.770

High

557126

PGFRA
Platelet-derived growth factor receptor alpha

1

4

High-throughput

0.691

High

801144

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.691

High

1038966

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

11

High-throughput

0.691

High

1057182

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.679

High

1057195

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

3

1

High-throughput

0.667

High

1057164

MELK
Maternal embryonic leucine zipper kinase

1

16

Small-scale

0.647

High

976211

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.638

High

612106

PROZ
Vitamin K-dependent protein Z

2

1

High-throughput

0.628

High

646891

1433T
14-3-3 protein theta

2

20

High-throughput

0.628

High

683350

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.628

High

904564

1433G
14-3-3 protein gamma

2

20

High-throughput

0.628

High

909567

1433E
14-3-3 protein epsilon

2

20

High-throughput

0.628

High

927047

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.628

High

982015

1433F
14-3-3 protein eta

2

20

High-throughput

0.628

High

1057217

PCDG5
Protocadherin gamma-A5

2

3

High-throughput

0.628

High

71120

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.618

High

166559

DCLK1
Serine/threonine-protein kinase DCLK1

1

13

High-throughput

0.618

High

230873

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

15

High-throughput

0.618

High

274221

STK16
Serine/threonine-protein kinase 16

1

16

High-throughput

0.618

High

545381

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

779413

CCNF
Cyclin-F

1

2

High-throughput

0.618

High

894016

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

925283

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

960363

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.618

High

1034854

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.618

High

1057165

ZN638
Zinc finger protein 638

1

4

High-throughput

0.618

High

1057174

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

1057178

KSR1
Kinase suppressor of Ras 1

1

11

High-throughput

0.618

High

1057184

SRS12
Serine/arginine-rich splicing factor 12

1

5

High-throughput

0.618

High

1057191

TESK2
Dual specificity testis-specific protein kinase 2

1

4

High-throughput

0.618

High

1057200

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.618

High

1057201

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1057203

KI13B
Kinesin-like protein KIF13B

1

4

High-throughput

0.618

High

1057206

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.618

High

1057212

PPM1H
Protein phosphatase 1H

1

17

High-throughput

0.618

High

1057213

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.618

High

1057197

LST8
Target of rapamycin complex subunit LST8

2

2

High-throughput

0.611

High

1057196

RTKN
Rhotekin

1

0

High-throughput

0.586

High

217884

PRKY
Putative serine/threonine-protein kinase PRKY

1

19

High-throughput

0.575

High

1056190

I13R2
Interleukin-13 receptor subunit alpha-2

2

2

High-throughput

0.574

High

1057198

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

Small-scale

0.572

High

1057173

AN34A
Ankyrin repeat domain-containing protein 34A

1

4

High-throughput

0.553

High

364894

FRIL
Ferritin light chain

1

2

High-throughput

0.536

High

933813

TBB4B
Tubulin beta-4B chain

1

4

High-throughput

0.536

High

992666

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.536

High

1057176

RUFY3
Protein RUFY3

1

5

High-throughput

0.536

High

1057192

CDC5L
Cell division cycle 5-like protein

1

10

High-throughput

0.536

High

1057199

CAD23
Cadherin-23

1

2

High-throughput

0.536

High

1057210

PNMA2
Paraneoplastic antigen Ma2

1

7

High-throughput

0.536

High

1057216

PCDB6
Protocadherin beta-6

1

3

High-throughput

0.536

High

1057218

PCDG4
Protocadherin gamma-A4

1

3

High-throughput

0.536

High

1057219

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

1057211

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.517

High

207236

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.513

High

497023

TAU
Microtubule-associated protein tau

1

8

Small-scale

0.501

High

595225

LMNB1
Lamin-B1

1

4

Small-scale

0.501

High

1057204

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.493

High

271960

CTAG2
Cancer/testis antigen 2

1

1

High-throughput

0.489

High

795958

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.489

High

1057166

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.489

High

362087

MBP
Myelin basic protein

1

0

Small-scale

0.480

High

196441

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.479

High

237218

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

346790

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

880727

HDAC4
Histone deacetylase 4

1

8

High-throughput

0.479

High

1025384

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

13

High-throughput

0.479

High

1041583

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1057171

SPD2A
SH3 and PX domain-containing protein 2A

1

5

High-throughput

0.479

High

1057172

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1057177

TAXB1
Tax1-binding protein 1

1

13

High-throughput

0.479

High

1057190

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

10

High-throughput

0.479

High

1057194

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1057207

CING
Cingulin

1

6

High-throughput

0.479

High

1057208

LIMA1
LIM domain and actin-binding protein 1

1

2

High-throughput

0.479

High

1057209

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

9

High-throughput

0.479

High

1057215

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

High-throughput

0.479

High

1057168

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.470

High

1057185

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

Small-scale

0.460

High

253351

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

1057193

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

264309

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.437

High

1057170

RC3H1
Roquin-1

1

4

High-throughput

0.437

High

1057175

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.437

High

1057180

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1057183

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.437

High

1057214

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.437

High

1057202

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1057181

RHPN1
Rhophilin-1

2

0

High-throughput

0.328

High

1057186

SNX21
Sorting nexin-21

2

0

High-throughput

0.328

High

532957

PRG2
Bone marrow proteoglycan

2

0

High-throughput

0.318

High

1057167

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

Small-scale

0.292

High

180035

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.279

Low

319558

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

875840

MFAP4
Microfibril-associated glycoprotein 4

1

0

High-throughput

0.279

Low

1030785

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1032336

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

1057169

PSMG4
Proteasome assembly chaperone 4

1

0

High-throughput

0.279

Low

1057179

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low

1057187

PSMG2
Proteasome assembly chaperone 2

1

0

High-throughput

0.279

Low

1057188

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

1057189

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

1057205

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024