Protein: MTR1B
Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)

Gene: MTR1B, MTNR1B
Organism: Homo sapiens
Interactions: 141
UniProt ID: P49286

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007187 - G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 - chemical synaptic transmission

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

825681

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

19

Small-scale

0.819

High

391355

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

19

Small-scale

0.789

High

444688

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

2

19

Small-scale

0.789

High

825679

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

7

Small-scale

0.789

High

825701

PDIA6
Protein disulfide-isomerase A6

2

4

Small-scale

0.789

High

825746

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

7

Small-scale

0.789

High

825674

COPA
Coatomer subunit alpha

2

0

Small-scale

0.660

High

825680

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

18

High-throughput

0.656

High

815844

MTR1A
Melatonin receptor type 1A

1

17

Small-scale

0.646

High

658213

5HT2C
5-hydroxytryptamine receptor 2C

1

16

Small-scale

0.618

High

825693

MTR1L
Melatonin-related receptor

1

17

Small-scale

0.618

High

598007

FLNA
Filamin-A

2

11

Small-scale

0.614

High

151738

IRS4
Insulin receptor substrate 4

2

1

Small-scale

0.611

High

501826

BIP
Endoplasmic reticulum chaperone BiP

2

2

Small-scale

0.611

High

646721

1433T
14-3-3 protein theta

2

9

Small-scale

0.611

High

671751

PDIA3
Protein disulfide-isomerase A3

1

4

High-throughput

0.587

High

825721

DMXL2
DmX-like protein 2

1

9

High-throughput

0.587

High

825743

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

1

High-throughput

0.587

High

825748

ITM2C
Integral membrane protein 2C

2

0

Small-scale

0.585

High

654167

CALX
Calnexin

2

5

Small-scale

0.558

High

825731

VPS35
Vacuolar protein sorting-associated protein 35

2

1

Small-scale

0.558

High

787634

PI4KA
Phosphatidylinositol 4-kinase alpha

2

8

Small-scale

0.552

High

505522

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

1

High-throughput

0.541

High

616960

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

3

High-throughput

0.541

High

825692

GPM6B
Neuronal membrane glycoprotein M6-b

1

1

High-throughput

0.541

High

825732

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

1

2

High-throughput

0.541

High

825756

GGT7
Glutathione hydrolase 7

1

1

High-throughput

0.541

High

825759

PCDBA
Protocadherin beta-10

1

2

High-throughput

0.541

High

488617

ARAF
Serine/threonine-protein kinase A-Raf

2

2

High-throughput

0.521

High

437298

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.518

High

229544

ADCY3
Adenylate cyclase type 3

1

1

High-throughput

0.508

High

439233

MMP2
72 kDa type IV collagenase

1

5

High-throughput

0.508

High

521497

ACTN1
Alpha-actinin-1

1

4

High-throughput

0.508

High

536067

CD99
CD99 antigen

1

1

High-throughput

0.508

High

716623

CTNA1
Catenin alpha-1

1

2

High-throughput

0.508

High

738651

TNR3
Tumor necrosis factor receptor superfamily member 3

1

2

High-throughput

0.508

High

738944

SRBP1
Sterol regulatory element-binding protein 1

1

3

High-throughput

0.508

High

825676

CADH4
Cadherin-4

1

5

High-throughput

0.508

High

825677

CAD11
Cadherin-11

1

3

High-throughput

0.508

High

825678

CAD13
Cadherin-13

1

9

High-throughput

0.508

High

825691

S39A6
Zinc transporter ZIP6

1

5

High-throughput

0.508

High

825694

CUL3
Cullin-3

1

2

High-throughput

0.508

High

825698

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

1

High-throughput

0.508

High

825707

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.508

High

825719

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

1

High-throughput

0.508

High

825744

EVA1A
Protein eva-1 homolog A

1

1

High-throughput

0.508

High

825755

UBQL2
Ubiquilin-2

1

3

High-throughput

0.508

High

825761

S12A4
Solute carrier family 12 member 4

1

3

High-throughput

0.508

High

825763

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

9

High-throughput

0.508

High

825767

TLN1
Talin-1

1

6

High-throughput

0.508

High

825771

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

3

High-throughput

0.508

High

825772

S4A7
Sodium bicarbonate cotransporter 3

1

1

High-throughput

0.508

High

825704

Q4LE69
1-phosphatidylinositol 4-kinase

1

7

High-throughput

0.501

High

283174

RGS20
Regulator of G-protein signaling 20

1

11

Small-scale

0.500

High

500397

THA
Thyroid hormone receptor alpha

1

1

High-throughput

0.494

High

683200

1433B
14-3-3 protein beta/alpha

1

9

High-throughput

0.494

High

825702

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

1

High-throughput

0.494

High

825724

TM230
Transmembrane protein 230

1

2

High-throughput

0.494

High

825739

MFF
Mitochondrial fission factor

1

1

High-throughput

0.494

High

825742

RNF41
E3 ubiquitin-protein ligase NRDP1

1

4

High-throughput

0.494

High

825752

DISP3
Protein dispatched homolog 3

1

1

High-throughput

0.494

High

825770

TM14A
Transmembrane protein 14A

1

1

High-throughput

0.494

High

328432

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

1

0

High-throughput

0.486

High

825684

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

825703

ACKR1
Atypical chemokine receptor 1

1

19

High-throughput

0.481

High

170299

TIF1A
Transcription intermediary factor 1-alpha

1

2

High-throughput

0.464

High

231856

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

1

High-throughput

0.464

High

256226

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

2

High-throughput

0.464

High

436074

ANXA6
Annexin A6

1

2

High-throughput

0.464

High

825675

XPO2
Exportin-2

1

6

High-throughput

0.464

High

825682

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.464

High

825683

DYST
Dystonin

1

11

High-throughput

0.464

High

825685

RHG01
Rho GTPase-activating protein 1

1

3

High-throughput

0.464

High

825686

AP1B1
AP-1 complex subunit beta-1

1

2

High-throughput

0.464

High

825687

SRBP2
Sterol regulatory element-binding protein 2

1

3

High-throughput

0.464

High

825688

FSTL1
Follistatin-related protein 1

1

3

High-throughput

0.464

High

825695

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

High-throughput

0.464

High

825696

UBP2L
Ubiquitin-associated protein 2-like

1

3

High-throughput

0.464

High

825697

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.464

High

825699

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

6

High-throughput

0.464

High

825708

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

1

High-throughput

0.464

High

825713

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

1

High-throughput

0.464

High

825714

MON2
Protein MON2 homolog

1

6

High-throughput

0.464

High

825715

CLAP1
CLIP-associating protein 1

1

7

High-throughput

0.464

High

825716

TRI46
Tripartite motif-containing protein 46

1

1

High-throughput

0.464

High

825718

INT1
Integrator complex subunit 1

1

5

High-throughput

0.464

High

825720

KMT2C
Histone-lysine N-methyltransferase 2C

1

2

High-throughput

0.464

High

825722

IPO4
Importin-4

1

2

High-throughput

0.464

High

825723

SYNE2
Nesprin-2

1

11

High-throughput

0.464

High

825726

RN185
E3 ubiquitin-protein ligase RNF185

1

5

High-throughput

0.464

High

825728

CREL1
Protein disulfide isomerase CRELD1

1

2

High-throughput

0.464

High

825729

COG8
Conserved oligomeric Golgi complex subunit 8

1

1

High-throughput

0.464

High

825730

IPO9
Importin-9

1

10

High-throughput

0.464

High

825740

BTBD1
BTB/POZ domain-containing protein 1

1

4

High-throughput

0.464

High

825745

COG4
Conserved oligomeric Golgi complex subunit 4

1

3

High-throughput

0.464

High

825747

PIDD1
p53-induced death domain-containing protein 1

1

2

High-throughput

0.464

High

825749

UBQL4
Ubiquilin-4

1

3

High-throughput

0.464

High

825758

HECD1
E3 ubiquitin-protein ligase HECTD1

1

5

High-throughput

0.464

High

825762

AP4E1
AP-4 complex subunit epsilon-1

1

3

High-throughput

0.464

High

825773

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

1

High-throughput

0.464

High

126109

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

0

Small-scale

0.458

High

825705

Q4VBN9
Atypical chemokine receptor 1

1

19

High-throughput

0.457

High

239078

CTND1
Catenin delta-1

1

5

High-throughput

0.445

High

825709

Q60FE5
Filamin A

1

14

High-throughput

0.445

High

73090

B4DXL2
cDNA FLJ58638, highly similar to Homo sapiens Rho GTPase activating protein 28

1

8

High-throughput

0.439

High

825757

ERG28
Ergosterol biosynthetic protein 28 homolog

1

1

High-throughput

0.439

High

825711

Q6FII3
C14orf1 protein

1

1

High-throughput

0.417

High

825753

RHG28
Rho GTPase-activating protein 28

1

8

High-throughput

0.417

High

176139

PPM1G
Protein phosphatase 1G

2

0

Small-scale

0.319

High

146905

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

0

High-throughput

0.282

High

825717

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

High-throughput

0.282

High

825738

PIP30
PSME3-interacting protein

1

0

High-throughput

0.282

High

825741

STMN4
Stathmin-4

1

0

High-throughput

0.282

High

825751

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.282

High

825760

POLI
DNA polymerase iota

1

0

High-throughput

0.282

High

364844

FRIL
Ferritin light chain

1

0

High-throughput

0.265

Low

517878

HARS1
Histidine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.265

Low

571798

XBP1
X-box-binding protein 1

1

0

High-throughput

0.265

Low

686411

OTX1
Homeobox protein OTX1

1

0

High-throughput

0.265

Low

819776

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.265

Low

825689

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.265

Low

825690

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.265

Low

825700

ESPL1
Separin

1

0

High-throughput

0.265

Low

825706

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.265

Low

825710

PCX4
Pecanex-like protein 4

1

0

High-throughput

0.265

Low

825712

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.265

Low

825725

THOC1
THO complex subunit 1

1

0

High-throughput

0.265

Low

825727

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.265

Low

825733

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.265

Low

825734

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.265

Low

825735

APOL6
Apolipoprotein L6

1

0

High-throughput

0.265

Low

825736

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.265

Low

825737

TNG6
Transport and Golgi organization protein 6 homolog

1

0

High-throughput

0.265

Low

825750

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.265

Low

825754

COE1
Transcription factor COE1

1

0

High-throughput

0.265

Low

825764

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

0

High-throughput

0.265

Low

825765

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.265

Low

825766

MTMR6
Myotubularin-related protein 6

1

0

High-throughput

0.265

Low

825768

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.265

Low

825769

RIPR2
Rho family-interacting cell polarization regulator 2

1

0

High-throughput

0.265

Low

90449

E1B2J3
Methyl CpG binding protein 2 transcript variant 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024