Protein: HBA
Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain) [Cleaved into: Hemopressin]

Gene: HBA, HBA1;
Organism: Homo sapiens
Interactions: 149
UniProt ID: P69905

Gene Ontology (top 5):
GO:0004601 - peroxidase activity
GO:0005344 - oxygen carrier activity
GO:0005506 - iron ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

935762

HBB
Hemoglobin subunit beta

15

18

Small-scale

0.984

High

355201

HBE
Hemoglobin subunit epsilon

3

18

Small-scale

0.849

High

936018

HBG2
Hemoglobin subunit gamma-2

3

18

Small-scale

0.849

High

355144

HBD
Hemoglobin subunit delta

2

18

High-throughput

0.783

High

447719

HBAT
Hemoglobin subunit theta-1

2

16

High-throughput

0.783

High

936090

AHSP
Alpha-hemoglobin-stabilizing protein

2

0

Small-scale

0.738

High

335400

NB5R3
NADH-cytochrome b5 reductase 3

1

3

Small-scale

0.724

High

667674

NOS3
Nitric oxide synthase 3

1

1

Small-scale

0.724

High

198431

KLK10
Kallikrein-10

1

2

High-throughput

0.691

High

596342

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

3

1

High-throughput

0.667

High

936062

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.667

High

936068

IGSF8
Immunoglobulin superfamily member 8

3

2

High-throughput

0.667

High

936087

PGPI
Pyroglutamyl-peptidase 1

3

1

High-throughput

0.667

High

936031

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.656

High

227138

PRKN
E3 ubiquitin-protein ligase parkin

3

2

High-throughput

0.640

High

305213

NXPH2
Neurexophilin-2

3

0

High-throughput

0.638

High

195976

PLXB1
Plexin-B1

2

2

High-throughput

0.628

High

503875

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

675610

GSTT1
Glutathione S-transferase theta-1

2

1

High-throughput

0.628

High

702338

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

1

High-throughput

0.628

High

879386

FCGRN
IgG receptor FcRn large subunit p51

2

1

High-throughput

0.628

High

936044

MK06
Mitogen-activated protein kinase 6

2

3

High-throughput

0.628

High

936064

GTR14
Solute carrier family 2, facilitated glucose transporter member 14

2

1

High-throughput

0.628

High

936070

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

1

High-throughput

0.628

High

936079

REN3A
Regulator of nonsense transcripts 3A

2

2

High-throughput

0.628

High

588761

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

3

High-throughput

0.609

High

936050

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

3

1

High-throughput

0.609

High

280560

KRT34
Keratin, type I cuticular Ha4

2

4

High-throughput

0.606

High

936041

K1H1
Keratin, type I cuticular Ha1

2

4

High-throughput

0.606

High

936082

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

519330

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

1

High-throughput

0.574

High

936072

MACD1
ADP-ribose glycohydrolase MACROD1

2

1

High-throughput

0.574

High

936083

MSL2
E3 ubiquitin-protein ligase MSL2

2

1

High-throughput

0.574

High

936052

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.573

High

581666

VCAM1
Vascular cell adhesion protein 1

2

4

High-throughput

0.571

High

936040

ARHG6
Rho guanine nucleotide exchange factor 6

2

2

High-throughput

0.571

High

936098

NUFP1
FMR1-interacting protein NUFIP1

2

1

High-throughput

0.558

High

890597

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.541

High

126375

MATN2
Matrilin-2

1

2

High-throughput

0.536

High

132822

SDCB1
Syntenin-1

1

2

High-throughput

0.536

High

146908

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

1

High-throughput

0.536

High

171971

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

325686

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.536

High

328123

SG1D1
Secretoglobin family 1D member 1

1

2

High-throughput

0.536

High

361336

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.536

High

420822

H2B1J
Histone H2B type 1-J

1

1

High-throughput

0.536

High

441821

FGF4
Fibroblast growth factor 4

1

2

High-throughput

0.536

High

447740

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

2

High-throughput

0.536

High

681405

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.536

High

739068

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

801074

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

922800

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.536

High

936036

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.536

High

936048

FBLN7
Fibulin-7

1

1

High-throughput

0.536

High

936056

PXK
PX domain-containing protein kinase-like protein

1

3

High-throughput

0.536

High

936063

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

1

High-throughput

0.536

High

936071

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.536

High

936078

CSTL1
Cystatin-like 1

1

6

High-throughput

0.536

High

936084

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.536

High

936094

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

936099

DKKL1
Dickkopf-like protein 1

1

1

High-throughput

0.536

High

936100

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.536

High

936102

PLLP
Plasmolipin

1

1

High-throughput

0.536

High

936045

CCD57
Coiled-coil domain-containing protein 57

1

6

High-throughput

0.523

High

936042

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.518

High

484592

NT2NC
Notch homolog 2 N-terminal-like protein C

1

3

High-throughput

0.515

High

235793

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

454085

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.513

High

499352

CD28
T-cell-specific surface glycoprotein CD28

1

0

High-throughput

0.513

High

690141

GBP2
Guanylate-binding protein 2

1

0

High-throughput

0.513

High

795363

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.513

High

936039

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

936047

KLH22
Kelch-like protein 22

1

0

High-throughput

0.513

High

936054

UD2A3
UDP-glucuronosyltransferase 2A3

1

0

High-throughput

0.513

High

936080

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.513

High

936089

STMN3
Stathmin-3

1

0

High-throughput

0.513

High

936092

OPT
Opticin

1

0

High-throughput

0.513

High

359000

CRYAB
Alpha-crystallin B chain

1

2

Small-scale

0.501

High

427069

CATD
Cathepsin D

1

1

Small-scale

0.501

High

936103

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

936034

MERTK
Tyrosine-protein kinase Mer

1

5

High-throughput

0.500

High

173464

RER1
Protein RER1

1

1

High-throughput

0.489

High

183024

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

798418

LPAR6
Lysophosphatidic acid receptor 6

1

1

High-throughput

0.489

High

936043

TAF12
Transcription initiation factor TFIID subunit 12

1

1

High-throughput

0.489

High

936051

C1QL3
Complement C1q-like protein 3

1

1

High-throughput

0.489

High

936053

ARMD1
Armadillo-like helical domain containing protein 1

1

1

High-throughput

0.489

High

936061

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.489

High

936069

CI085
Uncharacterized protein C9orf85

1

1

High-throughput

0.489

High

936085

RIC8A
Synembryn-A

1

1

High-throughput

0.489

High

936101

T3JAM
TRAF3-interacting JNK-activating modulator

1

4

High-throughput

0.489

High

936032

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.486

High

936055

NT2NA
Notch homolog 2 N-terminal-like protein A

1

3

High-throughput

0.481

High

936081

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.480

High

282617

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

338269

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

363061

FINC
Fibronectin

1

1

High-throughput

0.479

High

363761

ALBU
Albumin

1

1

High-throughput

0.479

High

374037

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

530616

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

601887

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

8

High-throughput

0.479

High

817905

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

908349

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

936033

FOXO1
Forkhead box protein O1

1

3

High-throughput

0.479

High

936038

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

936046

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

936058

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

936059

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

936073

CP250
Centrosome-associated protein CEP250

1

3

High-throughput

0.479

High

936074

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

936086

ANLN
Anillin

1

1

High-throughput

0.479

High

936093

HDAC6
Histone deacetylase 6

1

4

Small-scale

0.479

High

936096

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

936097

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.479

High

489583

OSTP
Osteopontin

1

0

Small-scale

0.460

High

885204

ISK7
Serine protease inhibitor Kazal-type 7

1

0

Small-scale

0.460

High

936095

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.460

High

255675

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

354417

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

362338

B3AT
Band 3 anion transport protein

1

0

Small-scale

0.458

High

500765

CLUS
Clusterin

1

0

Small-scale

0.458

High

547532

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

637847

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

936037

CUL7
Cullin-7

1

0

High-throughput

0.458

High

936075

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

876756

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.457

High

936066

TSC1
Hamartin

1

4

Small-scale

0.457

High

496824

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

504

NBPFJ
Neuroblastoma breakpoint family member 19

1

1

High-throughput

0.439

High

665855

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

Small-scale

0.438

High

260489

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

346487

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

627425

NFYB
Nuclear transcription factor Y subunit beta

1

1

Small-scale

0.437

High

823866

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

877686

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.437

High

936035

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.437

High

936060

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.437

High

936065

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.437

High

936067

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

936076

ASXL3
Putative Polycomb group protein ASXL3

1

6

High-throughput

0.437

High

936077

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

936088

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

716981

CTNB1
Catenin beta-1

1

0

High-throughput

0.426

High

547779

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.407

High

258864

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

2

0

High-throughput

0.328

High

936057

TSN33
Tetraspanin-33

1

0

High-throughput

0.279

Low

936091

RN181
E3 ubiquitin-protein ligase RNF181

1

0

Small-scale

0.251

Low

303146

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

936049

ARM12
Armadillo repeat-containing protein 12

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024