Protein: UBP18
Ubl carboxyl-terminal hydrolase 18 (EC 3.4.19.12) (43 kDa ISG15-specific protease) (hUBP43) (ISG15-specific-processing protease) (Ubl thioesterase 18)

Gene: UBP18, USP18
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9UMW8

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

398138

ISG15
Ubiquitin-like protein ISG15

11

20

Small-scale

0.978

High

855329

STAT2
Signal transducer and activator of transcription 2

6

7

Small-scale

0.733

High

1031303

SKP2
S-phase kinase-associated protein 2

4

4

Small-scale

0.698

High

201464

M3K7
Mitogen-activated protein kinase kinase kinase 7

4

2

Small-scale

0.676

High

924215

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

Small-scale

0.618

High

1078066

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

17

High-throughput

0.618

High

992152

B2CL1
Bcl-2-like protein 1

2

2

Small-scale

0.584

High

1077980

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

2

1

Small-scale

0.584

High

1357341

NEMO
NF-kappa-B essential modulator

2

19

Small-scale

0.584

High

1076862

TWST1
Twist-related protein 1

1

4

Small-scale

0.561

High

1350624

UVRAG
UV radiation resistance-associated gene protein

2

0

Small-scale

0.559

High

1216597

ZDH17
Palmitoyltransferase ZDHHC17

1

5

High-throughput

0.541

High

548966

NDKA
Nucleoside diphosphate kinase A

1

1

High-throughput

0.515

High

891623

MYL6
Myosin light polypeptide 6

1

4

High-throughput

0.515

High

792087

HD
Huntingtin

1

2

High-throughput

0.515

High

1317487

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

73191

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

3

High-throughput

0.479

High

151930

IRS4
Insulin receptor substrate 4

1

3

Small-scale

0.479

High

158568

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

10

Small-scale

0.479

High

167632

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

14

Small-scale

0.479

High

177406

HDAC3
Histone deacetylase 3

1

8

Small-scale

0.479

High

213673

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

10

High-throughput

0.479

High

305047

DUS14
Dual specificity protein phosphatase 14

1

10

Small-scale

0.479

High

326819

SNAI1
Zinc finger protein SNAI1

1

12

Small-scale

0.479

High

517538

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

531303

EF2
Elongation factor 2

1

5

Small-scale

0.479

High

685106

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

707790

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.479

High

717429

CTNB1
Catenin beta-1

1

15

Small-scale

0.479

High

741102

ZEB1
Zinc finger E-box-binding homeobox 1

1

9

Small-scale

0.479

High

786505

STAT6
Signal transducer and activator of transcription 6

1

7

Small-scale

0.479

High

804374

NOTC1
Neurogenic locus notch homolog protein 1

1

6

Small-scale

0.479

High

818848

SOX9
Transcription factor SOX-9

1

16

Small-scale

0.479

High

826092

FAS
Fatty acid synthase

1

4

Small-scale

0.479

High

918137

H4
Histone H4

1

7

Small-scale

0.479

High

932916

EF1A1
Elongation factor 1-alpha 1

1

6

Small-scale

0.479

High

944479

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

Small-scale

0.479

High

984465

EF1A2
Elongation factor 1-alpha 2

1

6

Small-scale

0.479

High

994396

DHX9
ATP-dependent RNA helicase A

1

13

Small-scale

0.479

High

1035047

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.479

High

1037437

TBB3
Tubulin beta-3 chain

1

13

Small-scale

0.479

High

1054228

BECN1
Beclin-1

1

2

Small-scale

0.479

High

1162536

Q6PK50
Heat shock protein HSP 90-beta

1

6

High-throughput

0.479

High

1190127

MAVS
Mitochondrial antiviral-signaling protein

1

13

Small-scale

0.479

High

1192263

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

11

Small-scale

0.479

High

1203592

STING
Stimulator of interferon genes protein

1

8

Small-scale

0.479

High

1217458

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.479

High

1230566

CCAR2
Cell cycle and apoptosis regulator protein 2

1

3

Small-scale

0.479

High

1243084

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

1

Small-scale

0.479

High

1302687

RSF1
Remodeling and spacing factor 1

1

20

Small-scale

0.479

High

1305064

TTC1
Tetratricopeptide repeat protein 1

1

7

High-throughput

0.479

High

1312181

AASD1
Alanyl-tRNA editing protein Aarsd1

1

2

High-throughput

0.479

High

1315465

CAR11
Caspase recruitment domain-containing protein 11

1

4

Small-scale

0.479

High

1316125

KDM5D
Lysine-specific demethylase 5D

1

4

Small-scale

0.479

High

1318525

TRI31
E3 ubiquitin-protein ligase TRIM31

1

18

Small-scale

0.479

High

1348526

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

4

Small-scale

0.479

High

1355866

FKBPL
FK506-binding protein-like

1

9

High-throughput

0.479

High

1357338

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

Small-scale

0.479

High

1357340

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

3

Small-scale

0.479

High

1185541

KDM3B
Lysine-specific demethylase 3B

1

7

High-throughput

0.470

High

885629

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.458

High

897664

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1169296

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

Small-scale

0.458

High

1335134

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1285463

Q96BE0
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.437

High

1308526

Q9BPW0
Serine/threonine-protein phosphatase

1

5

High-throughput

0.437

High

819597

INAR2
Interferon alpha/beta receptor 2

5

0

Small-scale

0.368

High

1357339

TM14A
Transmembrane protein 14A

1

0

High-throughput

0.265

Low

1047473

PEBB
Core-binding factor subunit beta

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024