Protein: EP300
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)

Gene: EP300
Organism: Mus musculus
Interactions: 73
UniProt ID: B2RWS6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000123 - histone acetyltransferase complex
GO:0001223 - transcription coactivator binding
GO:0001666 - response to hypoxia
GO:0001756 - somitogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

74242

P53
Cellular tumor antigen p53

6

18

Small-scale

0.937

High

74299

KAT2B
Histone acetyltransferase KAT2B

3

20

Small-scale

0.835

High

74266

NCOA1
Nuclear receptor coactivator 1

2

20

Small-scale

0.806

High

74273

TF65
Transcription factor p65

4

18

Small-scale

0.677

High

74271

CREB1
Cyclic AMP-responsive element-binding protein 1

1

7

Small-scale

0.647

High

74291

H2A3
Histone H2A type 3

1

20

Small-scale

0.647

High

74300

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.647

High

63084

A5D6Q2
Nuclear receptor coactivator 3

1

20

Small-scale

0.618

High

74238

F8VPR5
histone acetyltransferase

1

18

Small-scale

0.618

High

74267

IRF3
Interferon regulatory factor 3

1

17

Small-scale

0.618

High

74282

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.618

High

74288

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

Small-scale

0.618

High

74305

FOXO3
Forkhead box protein O3

1

20

Small-scale

0.618

High

74247

MYOD1
Myoblast determination protein 1

2

7

Small-scale

0.584

High

74250

SPI1
Transcription factor PU.1

2

20

Small-scale

0.584

High

74276

RUNX2
Runt-related transcription factor 2

2

8

Small-scale

0.584

High

74275

GATA4
Transcription factor GATA-4

1

20

Small-scale

0.561

High

74304

TLE6
Transducin-like enhancer protein 6

1

16

High-throughput

0.541

High

74302

NUPR1
Nuclear protein 1

1

3

Small-scale

0.527

High

74256

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

Small-scale

0.515

High

59879

A2AWT7
Nucleolar transcription factor 1

1

20

Small-scale

0.501

High

74277

BMAL2
Basic helix-loop-helix ARNT-like protein 2

1

20

Small-scale

0.501

High

74303

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

20

Small-scale

0.501

High

74307

MECP2
Methyl-CpG-binding protein 2

1

20

Small-scale

0.501

High

378

AUTS2
Autism susceptibility gene 2 protein homolog

1

20

Small-scale

0.500

High

74240

INAR2
Interferon alpha/beta receptor 2

1

3

Small-scale

0.479

High

74244

GRAB
Granzyme B(G,H)

1

1

Small-scale

0.479

High

74245

SRC
Proto-oncogene tyrosine-protein kinase Src

1

15

Small-scale

0.479

High

74246

JUN
Transcription factor Jun

1

20

High-throughput

0.479

High

74248

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

74251

RARG
Retinoic acid receptor gamma

1

20

Small-scale

0.479

High

74252

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

74253

RARB
Retinoic acid receptor beta

1

20

Small-scale

0.479

High

74254

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

Small-scale

0.479

High

74255

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

74257

CEBPB
CCAAT/enhancer-binding protein beta

1

20

Small-scale

0.479

High

74258

ETV4
ETS translocation variant 4

1

20

Small-scale

0.479

High

74260

INAR1
Interferon alpha/beta receptor 1

1

2

Small-scale

0.479

High

74262

THB
Thyroid hormone receptor beta

1

20

High-throughput

0.479

High

74263

HSF2
Heat shock factor protein 2

1

6

Small-scale

0.479

High

74264

STAT6
Signal transducer and transcription activator 6

1

16

Small-scale

0.479

High

74265

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

Small-scale

0.479

High

74268

C2TA
MHC class II transactivator

1

6

Small-scale

0.479

High

74269

PITX2
Pituitary homeobox 2

1

20

Small-scale

0.479

High

74270

TYY1
Transcriptional repressor protein YY1

1

14

Small-scale

0.479

High

74272

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

74274

BAX
Apoptosis regulator BAX

1

5

Small-scale

0.479

High

74278

DDB1
DNA damage-binding protein 1

1

9

Small-scale

0.479

High

74279

Q3UM65
Runt-related transcription factor

1

8

Small-scale

0.479

High

74280

NR1H4
Bile acid receptor

1

20

Small-scale

0.479

High

74281

USF1
Upstream stimulatory factor 1

1

20

Small-scale

0.479

High

74283

HTF4
Transcription factor 12

1

9

Small-scale

0.479

High

74284

CNTN2
Contactin-2

1

2

Small-scale

0.479

High

74285

IL17
Interleukin-17A

1

1

Small-scale

0.479

High

74286

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

13

Small-scale

0.479

High

74287

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

20

Small-scale

0.479

High

74290

IL17F
Interleukin-17F

1

1

Small-scale

0.479

High

74292

SNIP1
Smad nuclear-interacting protein 1

1

5

Small-scale

0.479

High

74293

EPC1
Enhancer of polycomb homolog 1

1

2

Small-scale

0.479

High

74295

MYCD
Myocardin

1

12

Small-scale

0.479

High

74296

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

11

Small-scale

0.479

High

74297

FOXP3
Forkhead box protein P3

1

16

Small-scale

0.479

High

74298

BC11B
B-cell lymphoma/leukemia 11B

1

6

Small-scale

0.479

High

74239

XBP1
X-box-binding protein 1

1

0

Small-scale

0.458

High

74259

NOS2
Nitric oxide synthase, inducible

1

0

Small-scale

0.458

High

74249

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

14

Small-scale

0.445

High

74306

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.445

High

74241

IFNB
Interferon beta

1

10

Small-scale

0.437

High

74243

CFAD
Complement factor D

1

1

High-throughput

0.437

High

74289

Q6PED7
Auts2 protein

1

4

Small-scale

0.437

High

74261

TAP2
Antigen peptide transporter 2

1

0

Small-scale

0.249

Low

74294

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.249

Low

74301

TPSN
Tapasin

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025