Protein: SIAH1
E3 ubiquitin-protein ligase SIAH1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH1) (Seven in absentia homolog 1) (Siah-1) (Siah-1a)

Gene: SIAH1
Organism: Homo sapiens
Interactions: 230
UniProt ID: Q8IUQ4

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1216657

SIAH1
E3 ubiquitin-protein ligase SIAH1

13

16

Small-scale

0.980

High

199125

SIAH2
E3 ubiquitin-protein ligase SIAH2

4

17

Small-scale

0.910

High

1216716

CYBP
Calcyclin-binding protein

8

3

Small-scale

0.755

High

919778

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.734

High

1216711

HIPK2
Homeodomain-interacting protein kinase 2

5

12

Small-scale

0.732

High

895842

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.719

High

742383

SYUA
Alpha-synuclein

4

3

Small-scale

0.714

High

849364

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.714

High

1216659

PHC2
Polyhomeotic-like protein 2

4

5

Small-scale

0.707

High

301416

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

4

13

Small-scale

0.705

High

717199

CTNB1
Catenin beta-1

5

3

Small-scale

0.704

High

1216729

PUF60
Poly(U)-binding-splicing factor PUF60

4

3

Small-scale

0.698

High

669418

EF1D
Elongation factor 1-delta

3

1

Small-scale

0.682

High

896333

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

High-throughput

0.680

High

382060

G3P
Glyceraldehyde-3-phosphate dehydrogenase

4

3

Small-scale

0.676

High

267518

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

3

3

Small-scale

0.667

High

452831

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

1

High-throughput

0.667

High

1216734

MARE3
Microtubule-associated protein RP/EB family member 3

3

5

Small-scale

0.665

High

1216742

SNCAP
Synphilin-1

2

8

Small-scale

0.664

High

1216682

R51A1
RAD51-associated protein 1

3

0

High-throughput

0.646

High

833619

NUMB
Protein numb homolog

2

5

Small-scale

0.646

High

303608

UPP2
Uridine phosphorylase 2

2

2

High-throughput

0.646

High

1198451

PEG10
Retrotransposon-derived protein PEG10

2

1

Small-scale

0.641

High

170682

AXIN1
Axin-1

2

2

Small-scale

0.640

High

1043695

ASPP2
Apoptosis-stimulating of p53 protein 2

2

11

High-throughput

0.633

High

1216691

CTIP
DNA endonuclease RBBP8

2

1

Small-scale

0.631

High

1216692

MYD88
Myeloid differentiation primary response protein MyD88

2

7

Small-scale

0.631

High

1216676

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.626

High

1024869

KLF10
Krueppel-like factor 10

2

3

Small-scale

0.625

High

1216686

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

Small-scale

0.624

High

992594

ACK1
Activated CDC42 kinase 1

2

12

Small-scale

0.619

High

953094

PR20A
Proline-rich protein 20A

4

5

High-throughput

0.618

High

1216658

SIAH3
Seven in absentia homolog 3

1

11

Small-scale

0.618

High

957731

XIAP
E3 ubiquitin-protein ligase XIAP

2

7

Small-scale

0.612

High

278124

PIAS1
E3 SUMO-protein ligase PIAS1

2

8

Small-scale

0.606

High

314088

BAG4
BAG family molecular chaperone regulator 4

2

1

High-throughput

0.606

High

324485

BAG3
BAG family molecular chaperone regulator 3

2

1

High-throughput

0.606

High

1138554

SMBT2
Scm-like with four MBT domains protein 2

2

5

High-throughput

0.606

High

1216693

BAG1
BAG family molecular chaperone regulator 1

2

0

Small-scale

0.605

High

1026309

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

0

Small-scale

0.598

High

869491

ATN1
Atrophin-1

2

4

High-throughput

0.595

High

776733

STAT3
Signal transducer and activator of transcription 3

2

1

Small-scale

0.586

High

793644

DCC
Netrin receptor DCC

2

1

Small-scale

0.586

High

1216679

CSN5
COP9 signalosome complex subunit 5

2

1

Small-scale

0.586

High

1074934

TERF2
Telomeric repeat-binding factor 2

2

0

Small-scale

0.585

High

930288

UBC9
SUMO-conjugating enzyme UBC9

2

20

Small-scale

0.584

High

1216670

M1AP
Meiosis 1 arrest protein

2

0

High-throughput

0.580

High

1216720

LANC2
LanC-like protein 2

2

0

High-throughput

0.580

High

1216690

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

12

Small-scale

0.578

High

1216728

AFF4
AF4/FMR2 family member 4

2

10

High-throughput

0.578

High

130162

ELL2
RNA polymerase II elongation factor ELL2

2

1

Small-scale

0.575

High

269166

DAB1
Disabled homolog 1

1

5

Small-scale

0.573

High

1059544

KIF22
Kinesin-like protein KIF22

1

3

Small-scale

0.573

High

132930

SDCB1
Syntenin-1

1

4

High-throughput

0.573

High

207694

SYT7
Synaptotagmin-7

1

2

High-throughput

0.573

High

231603

KIF1B
Kinesin-like protein KIF1B

1

5

High-throughput

0.573

High

231826

MABP1
Mitogen-activated protein kinase-binding protein 1

1

3

High-throughput

0.573

High

536908

TRI27
Zinc finger protein RFP

1

8

High-throughput

0.573

High

594258

MX1
Interferon-induced GTP-binding protein Mx1

1

1

High-throughput

0.573

High

734678

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.573

High

781392

BCL6
B-cell lymphoma 6 protein

1

5

High-throughput

0.573

High

827966

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

High-throughput

0.573

High

864837

MK12
Mitogen-activated protein kinase 12

1

7

High-throughput

0.573

High

917546

H4
Histone H4

1

1

High-throughput

0.573

High

965408

FLI1
Friend leukemia integration 1 transcription factor

1

1

High-throughput

0.573

High

1033027

MB211
Putative nucleotidyltransferase MAB21L1

1

1

High-throughput

0.573

High

1102926

QRIC1
Transcriptional regulator QRICH1

1

2

High-throughput

0.573

High

1216673

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.573

High

1216674

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

1

High-throughput

0.573

High

1216675

ZCH13
Zinc finger CCHC domain-containing protein 13

1

2

High-throughput

0.573

High

1216683

OTUB2
Ubiquitin thioesterase OTUB2

1

2

High-throughput

0.573

High

1216684

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

4

High-throughput

0.573

High

1216685

Z512B
Zinc finger protein 512B

1

4

High-throughput

0.573

High

1216703

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

7

High-throughput

0.573

High

1216712

NELFA
Negative elongation factor A

1

1

High-throughput

0.573

High

1216730

DDX41
Probable ATP-dependent RNA helicase DDX41

1

2

High-throughput

0.573

High

1216731

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.573

High

1216739

ARIP4
Helicase ARIP4

1

2

High-throughput

0.573

High

626185

APC
Adenomatous polyposis coli protein

1

6

Small-scale

0.561

High

848247

HCFC1
Host cell factor 1

1

2

Small-scale

0.561

High

1216700

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

Small-scale

0.561

High

1216741

HCFC2
Host cell factor 2

1

2

Small-scale

0.561

High

1216701

PAR6B
Partitioning defective 6 homolog beta

1

1

High-throughput

0.560

High

1216705

RB33B
Ras-related protein Rab-33B

2

2

High-throughput

0.553

High

173974

ATX7
Ataxin-7

1

1

High-throughput

0.552

High

783784

GRM5
Metabotropic glutamate receptor 5

1

2

Small-scale

0.552

High

957583

PKD1
Polycystin-1

1

2

Small-scale

0.552

High

1216688

TRIB3
Tribbles homolog 3

1

2

Small-scale

0.552

High

1216704

PEG3
Paternally-expressed gene 3 protein

1

1

Small-scale

0.552

High

151322

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.549

High

437774

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

High-throughput

0.549

High

506192

PYGB
Glycogen phosphorylase, brain form

1

0

High-throughput

0.549

High

670363

AQP1
Aquaporin-1

1

0

High-throughput

0.549

High

768442

CAPG
Macrophage-capping protein

1

0

High-throughput

0.549

High

1121394

LACB2
Endoribonuclease LACTB2

1

0

High-throughput

0.549

High

1133620

SKT
Sickle tail protein homolog

1

0

High-throughput

0.549

High

1174255

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.549

High

1189150

ARMC9
LisH domain-containing protein ARMC9

1

0

High-throughput

0.549

High

1203659

AROS
Active regulator of SIRT1

1

0

High-throughput

0.549

High

1216664

SPAT4
Spermatogenesis-associated protein 4

1

0

High-throughput

0.549

High

1216669

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.549

High

1216699

KATL1
Katanin p60 ATPase-containing subunit A-like 1

1

0

High-throughput

0.549

High

1216706

SPC1L
Speriolin-like protein

1

0

High-throughput

0.549

High

1216707

IQCN
IQ domain-containing protein N

1

0

High-throughput

0.549

High

1216710

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.549

High

1216715

ZMAT3
Zinc finger matrin-type protein 3

1

0

High-throughput

0.549

High

1216719

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

1

0

High-throughput

0.549

High

1216727

UXT
Protein UXT

1

0

High-throughput

0.549

High

659725

RXRB
Retinoic acid receptor RXR-beta

1

5

High-throughput

0.541

High

896488

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.541

High

1078860

ITSN1
Intersectin-1

1

1

High-throughput

0.541

High

1079002

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.541

High

1216702

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

13

High-throughput

0.541

High

1216737

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.541

High

1065130

DAZP2
DAZ-associated protein 2

1

0

Small-scale

0.537

High

1216725

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

Small-scale

0.537

High

412253

FYN
Tyrosine-protein kinase Fyn

1

3

High-throughput

0.536

High

723066

OPRM
Mu-type opioid receptor

1

7

Small-scale

0.535

High

850816

AFF1
AF4/FMR2 family member 1

1

7

Small-scale

0.535

High

1048021

RB33A
Ras-related protein Rab-33A

1

2

High-throughput

0.523

High

1205575

F90A1
Protein FAM90A1

1

1

High-throughput

0.523

High

1216677

NECT2
Nectin-2

1

2

High-throughput

0.523

High

1216694

ZFY21
Zinc finger FYVE domain-containing protein 21

1

4

High-throughput

0.523

High

1216698

KIFC3
Kinesin-like protein KIFC3

1

2

High-throughput

0.523

High

1216721

TB22B
TBC1 domain family member 22B

1

1

High-throughput

0.523

High

1216735

ZN148
Zinc finger protein 148

1

5

High-throughput

0.523

High

1216695

PIMRE
Protein PIMREG

1

0

High-throughput

0.518

High

781042

OPRK
Kappa-type opioid receptor

1

7

Small-scale

0.515

High

1216671

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

11

High-throughput

0.515

High

57974

A2RRL9
Z-DNA binding protein 1

1

2

High-throughput

0.515

High

261543

NCOR1
Nuclear receptor corepressor 1

1

7

High-throughput

0.515

High

395107

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.515

High

822313

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.515

High

868592

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

987523

APLP2
Amyloid beta precursor like protein 2

1

5

High-throughput

0.515

High

1025830

TADBP
TAR DNA-binding protein 43

1

9

High-throughput

0.515

High

1123980

Q59GP6
Polyhomeotic-like protein 1 variant

1

6

High-throughput

0.515

High

1151436

Q6FIE9
TOLLIP protein

1

1

High-throughput

0.515

High

1200887

Q86V38
Atrophin 1

1

4

High-throughput

0.515

High

1216662

Q8N619
Cyclin-dependent kinase 5 activator

1

2

High-throughput

0.515

High

1216665

Q8TAM4
Cyclin-dependent kinase 5 activator

1

2

High-throughput

0.515

High

1216666

Q8TAN2
Frizzled homolog 9

1

3

High-throughput

0.515

High

1216678

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

234964

SNX3
Sorting nexin-3

1

0

High-throughput

0.513

High

738233

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

1

Small-scale

0.512

High

198196

SEPT4
Septin-4

1

0

Small-scale

0.512

High

1216713

HIPK3
Homeodomain-interacting protein kinase 3

1

16

High-throughput

0.508

High

1075426

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

5

Small-scale

0.506

High

1160936

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

Small-scale

0.504

High

952974

PR20E
Proline-rich protein 20E

2

5

High-throughput

0.504

High

159072

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

Small-scale

0.501

High

1080708

ZYX
Zyxin

1

7

Small-scale

0.501

High

1216744

PIAS3
E3 SUMO-protein ligase PIAS3

1

8

Small-scale

0.501

High

1216732

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

2

High-throughput

0.489

High

117054

FZD9
Frizzled-9

1

3

High-throughput

0.481

High

278304

PIAS2
E3 SUMO-protein ligase PIAS2

1

8

Small-scale

0.481

High

360119

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.481

High

548730

VAV
Proto-oncogene vav

1

2

Small-scale

0.481

High

805721

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.481

High

943071

PHC1
Polyhomeotic-like protein 1

1

5

High-throughput

0.481

High

1050516

TFDP1
Transcription factor Dp-1

1

1

High-throughput

0.481

High

1067683

CD5R1
Cyclin-dependent kinase 5 activator 1

1

2

High-throughput

0.481

High

1173957

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

1

High-throughput

0.481

High

1216667

ZN671
Zinc finger protein 671

1

1

High-throughput

0.481

High

1216680

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.481

High

1216708

TOLIP
Toll-interacting protein

1

1

High-throughput

0.481

High

1216709

ZBP1
Z-DNA-binding protein 1

1

2

High-throughput

0.481

High

1216743

NUMBL
Numb-like protein

1

6

High-throughput

0.481

High

175891

P73
Tumor protein p73

1

2

Small-scale

0.479

High

236795

CCNT1
Cyclin-T1

1

2

Small-scale

0.479

High

245616

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

4

Small-scale

0.479

High

436630

TNR16
Tumor necrosis factor receptor superfamily member 16

1

20

Small-scale

0.479

High

487992

RARA
Retinoic acid receptor alpha

1

6

Small-scale

0.479

High

668808

PML
Protein PML

1

11

Small-scale

0.479

High

804135

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

1

Small-scale

0.479

High

804283

NOTC1
Neurogenic locus notch homolog protein 1

1

3

Small-scale

0.479

High

808749

YAP1
Transcriptional coactivator YAP1

1

6

Small-scale

0.479

High

832568

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

907089

PRS8
26S proteasome regulatory subunit 8

1

1

Small-scale

0.479

High

913307

PRS10
26S proteasome regulatory subunit 10B

1

1

Small-scale

0.479

High

931257

YBOX1
Y-box-binding protein 1

1

2

Small-scale

0.479

High

1014163

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

1

Small-scale

0.479

High

1041974

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1191845

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

13

Small-scale

0.479

High

1206214

HIPK1
Homeodomain-interacting protein kinase 1

1

14

Small-scale

0.479

High

1216672

PARD3
Partitioning defective 3 homolog

1

11

Small-scale

0.479

High

1216689

RING2
E3 ubiquitin-protein ligase RING2

1

13

High-throughput

0.479

High

1216697

TRAF4
TNF receptor-associated factor 4

1

18

Small-scale

0.479

High

1216718

LATS2
Serine/threonine-protein kinase LATS2

1

7

Small-scale

0.479

High

1216723

RNF12
E3 ubiquitin-protein ligase RLIM

1

4

Small-scale

0.479

High

1216726

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

2

Small-scale

0.479

High

1216733

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.479

High

1216736

AXIN2
Axin-2

1

2

Small-scale

0.479

High

952992

PR20C
Proline-rich protein 20C

1

5

High-throughput

0.470

High

953026

PR20D
Proline-rich protein 20D

1

5

High-throughput

0.470

High

1216681

COQA1
Collagen alpha-1(XXVI) chain

1

1

High-throughput

0.470

High

495566

THIO
Thioredoxin

1

0

High-throughput

0.460

High

1216663

SLAI1
SLAIN motif-containing protein 1

1

0

Small-scale

0.460

High

418435

NPM
Nucleophosmin

1

0

Small-scale

0.458

High

791733

HD
Huntingtin

1

0

Small-scale

0.458

High

964366

RUNX1
Runt-related transcription factor 1

1

0

Small-scale

0.458

High

1062916

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

Small-scale

0.458

High

1216724

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

439142

SYPH
Synaptophysin

1

2

Small-scale

0.457

High

3212

A0A0S2Z4M1
Axin-1

1

2

High-throughput

0.457

High

3496

A0A0S2Z6U5
Uridine phosphorylase

1

2

High-throughput

0.457

High

1216717

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

1145821

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.445

High

158330

PCD17
Protocadherin-17

1

1

Small-scale

0.439

High

373133

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

2

Small-scale

0.437

High

781025

OPRD
Delta-type opioid receptor

1

7

Small-scale

0.437

High

3450

A0A0S2Z639
Uridine phosphorylase 2 isoform 4

1

2

High-throughput

0.417

High

72145

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.417

High

1216668

Q8TAX5
AFF4 protein

1

6

High-throughput

0.417

High

1216687

JSPR1
Junctional sarcoplasmic reticulum protein 1

3

0

High-throughput

0.347

High

1084689

OBF1
POU domain class 2-associating factor 1

2

0

Small-scale

0.341

High

396838

INHA
Inhibin alpha chain

2

0

High-throughput

0.341

High

1216696

TMM43
Transmembrane protein 43

2

0

High-throughput

0.341

High

1101844

EX3L2
Exocyst complex component 3-like protein 2

2

0

High-throughput

0.328

High

944145

KCJ10
ATP-sensitive inward rectifier potassium channel 10

1

0

High-throughput

0.299

High

1216660

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.299

High

1216661

EXAS1
Uncharacterized protein EXOC3-AS1

1

0

High-throughput

0.299

High

1216714

NOL6
Nucleolar protein 6

1

0

High-throughput

0.299

High

1216722

FAME
Factor associated with metabolism and energy

1

0

High-throughput

0.299

High

1216740

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.299

High

947829

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.279

Low

793793

CATK
Cathepsin K

1

0

Small-scale

0.251

Low

1216738

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1169525

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024