Protein: LAT1
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)

Gene: LAT1, SLC7A5
Organism: Homo sapiens
Interactions: 172
UniProt ID: Q01650

Gene Ontology (top 5):
GO:0002720 - positive regulation of cytokine production involved in immune response
GO:0003333 - amino acid transmembrane transport
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

437334

4F2
Amino acid transporter heavy chain SLC3A2

4

10

Small-scale

0.909

High

793280

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

940398

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.618

High

205281

TGON2
Trans-Golgi network integral membrane protein 2

2

3

High-throughput

0.584

High

349255

RASH
GTPase HRas

2

17

High-throughput

0.584

High

350085

RASK
GTPase KRas

2

20

High-throughput

0.584

High

506972

LAMP1
Lysosome-associated membrane glycoprotein 1

2

11

High-throughput

0.584

High

914015

RB11A
Ras-related protein Rab-11A

2

2

High-throughput

0.584

High

915614

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

965639

IFM3
Interferon-induced transmembrane protein 3

2

2

High-throughput

0.584

High

369426

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

848538

CAV2
Caveolin-2

2

4

High-throughput

0.571

High

966057

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

2

High-throughput

0.571

High

966061

PAK1
Serine/threonine-protein kinase PAK 1

2

2

High-throughput

0.571

High

966062

MK07
Mitogen-activated protein kinase 7

2

2

High-throughput

0.571

High

966114

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

783985

KPCI
Protein kinase C iota type

2

0

High-throughput

0.547

High

338293

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.536

High

393166

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.536

High

848346

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

966082

MBOA1
Lysophospholipid acyltransferase 1

1

1

High-throughput

0.536

High

177868

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.515

High

966086

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.515

High

872009

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.513

High

966076

CSCL2
CSC1-like protein 2

1

0

High-throughput

0.513

High

966090

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.513

High

966095

NICA
Nicastrin

1

0

High-throughput

0.513

High

966096

NDRG1
Protein NDRG1

1

0

High-throughput

0.513

High

966104

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.513

High

966113

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

726156

BASI
Basigin

1

0

High-throughput

0.493

High

422381

NFM
Neurofilament medium polypeptide

1

1

High-throughput

0.489

High

119332

LEG9
Galectin-9

1

11

High-throughput

0.479

High

120394

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

148694

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

169437

BET1
BET1 homolog

1

5

High-throughput

0.479

High

178489

STX7
Syntaxin-7

1

9

High-throughput

0.479

High

212797

STX6
Syntaxin-6

1

5

High-throughput

0.479

High

232850

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

279515

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

294724

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

305417

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

318108

DIRA3
GTP-binding protein Di-Ras3

1

6

High-throughput

0.479

High

348622

RASN
GTPase NRas

1

20

High-throughput

0.479

High

386550

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

390183

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

390832

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

433703

LYN
Tyrosine-protein kinase Lyn

1

5

High-throughput

0.479

High

436259

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

456852

FURIN
Furin

1

1

High-throughput

0.479

High

503918

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

525905

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

527399

LAMP2
Lysosome-associated membrane glycoprotein 2

1

11

High-throughput

0.479

High

545328

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

547011

EZRI
Ezrin

1

4

High-throughput

0.479

High

564484

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

567013

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

591549

RAB3B
Ras-related protein Rab-3B

1

5

High-throughput

0.479

High

591816

RAB4A
Ras-related protein Rab-4A

1

12

High-throughput

0.479

High

592206

RAB5A
Ras-related protein Rab-5A

1

10

High-throughput

0.479

High

669989

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

719699

RADI
Radixin

1

3

High-throughput

0.479

High

825389

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

827914

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

844488

RAB5C
Ras-related protein Rab-5C

1

10

High-throughput

0.479

High

845441

RAB9A
Ras-related protein Rab-9A

1

10

High-throughput

0.479

High

852439

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

866930

MOT1
Monocarboxylate transporter 1

1

11

High-throughput

0.479

High

876359

AFAD
Afadin

1

2

High-throughput

0.479

High

881500

ARL4C
ADP-ribosylation factor-like protein 4C

1

13

High-throughput

0.479

High

882247

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

892323

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

893911

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

895044

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.479

High

900388

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

901128

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

901458

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.479

High

912858

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

925205

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

950476

ARF1
ADP-ribosylation factor 1

1

7

High-throughput

0.479

High

950931

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

966058

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

966060

STX4
Syntaxin-4

1

10

High-throughput

0.479

High

966064

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

2

High-throughput

0.479

High

966065

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

966066

RAB35
Ras-related protein Rab-35

1

6

High-throughput

0.479

High

966067

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.479

High

966069

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

966070

OCLN
Occludin

1

2

High-throughput

0.479

High

966071

MK06
Mitogen-activated protein kinase 6

1

5

High-throughput

0.479

High

966072

AR13B
ADP-ribosylation factor-like protein 13B

1

15

High-throughput

0.479

High

966073

MIDN
Midnolin

1

2

High-throughput

0.479

High

966078

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

966084

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

966088

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

966089

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.479

High

966091

RN149
E3 ubiquitin-protein ligase RNF149

1

5

High-throughput

0.479

High

966092

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

2

High-throughput

0.479

High

966093

PARD3
Partitioning defective 3 homolog

1

1

High-throughput

0.479

High

966094

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.479

High

966097

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

966098

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

966100

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

966101

CK052
Uncharacterized protein C11orf52

1

2

High-throughput

0.479

High

966105

AURKB
Aurora kinase B

1

4

High-throughput

0.479

High

966107

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

966109

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

966116

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

966118

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

966119

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

966121

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

966127

ELOV5
Very long chain fatty acid elongase 5

1

15

High-throughput

0.479

High

966128

TM216
Transmembrane protein 216

1

1

High-throughput

0.479

High

966129

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

3

High-throughput

0.479

High

966130

DNJ5B
DnaJ homolog subfamily C member 5B

1

3

High-throughput

0.479

High

966131

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

966133

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.479

High

966134

LAMP3
Lysosome-associated membrane glycoprotein 3

1

11

High-throughput

0.479

High

122672

MEN1
Menin

1

0

High-throughput

0.458

High

123571

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

146026

CLD4
Claudin-4

1

0

Small-scale

0.458

High

167899

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

547542

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

648727

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

718490

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

718768

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

807691

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

917129

H4
Histone H4

1

0

High-throughput

0.458

High

966059

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

966063

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

966068

ELOB
Elongin-B

1

0

High-throughput

0.458

High

966077

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

966079

CDC73
Parafibromin

1

0

High-throughput

0.458

High

966080

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

966085

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

966099

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

966103

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

966106

TMX3
Protein disulfide-isomerase TMX3

1

0

High-throughput

0.458

High

966112

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.458

High

966120

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

966122

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

966123

ANLN
Anillin

1

0

High-throughput

0.458

High

966124

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

966132

TES
Testin

1

0

High-throughput

0.458

High

966136

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

966137

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

92786

E9PS44
Interferon induced transmembrane protein 3

1

2

High-throughput

0.445

High

602244

CD9
CD9 antigen

1

4

High-throughput

0.445

High

966075

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

966115

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

966117

S38A1
Sodium-coupled neutral amino acid symporter 1

1

4

High-throughput

0.445

High

132452

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

486514

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.437

High

552521

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

650986

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

720255

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

940794

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

966074

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.437

High

966081

M3K15
Mitogen-activated protein kinase kinase kinase 15

1

2

High-throughput

0.437

High

966083

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

966087

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

966102

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.437

High

966056

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

966126

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

Small-scale

0.426

High

966111

IFT27
Intraflagellar transport protein 27 homolog

1

14

High-throughput

0.407

High

584237

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

966110

TBA1C
Tubulin alpha-1C chain

1

0

High-throughput

0.279

Low

182705

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

328811

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

966108

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

966125

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

966135

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024