Protein: GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

Gene: GNAO, goa-1
Organism: Caenorhabditis elegans
Interactions: 37
UniProt ID: P51875

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

908551

RIC8
Chaperone ric-8

5

12

Small-scale

0.946

High

908540

Q19955
Tetratricopeptide repeat protein 28

3

12

Small-scale

0.842

High

908546

RGS7
Regulator of G-protein signaling rgs-7

3

20

Small-scale

0.840

High

908549

Q965M4
Rap-GAP domain-containing protein

2

4

Small-scale

0.791

High

908548

GPR1
G-protein regulator 1

10

3

Small-scale

0.757

High

908538

GPR2
G-protein regulator 2

5

3

Small-scale

0.720

High

853163

LIN5
Spindle apparatus protein lin-5

2

6

Small-scale

0.584

High

758617

RGS1
Regulator of G-protein signaling rgs-1

1

20

Small-scale

0.579

High

890712

RGS2
Regulator of G-protein signaling rgs-2

1

20

Small-scale

0.579

High

908543

Q86RS9
Rap1GAP

1

4

Small-scale

0.570

High

112244

G5EE25
non-specific serine/threonine protein kinase

1

3

Small-scale

0.541

High

759271

LIN36
Protein lin-36

1

3

Small-scale

0.494

High

908544

Q86RT3
Nucleobindin

1

5

Small-scale

0.494

High

604385

GBB1
Guanine nucleotide-binding protein subunit beta-1

1

20

Small-scale

0.479

High

758714

PLK1
Serine/threonine-protein kinase plk-1

1

4

High-throughput

0.479

High

908537

P90735
Sodium/potassium-transporting ATPase subunit alpha

1

6

Small-scale

0.479

High

908552

Q9TXM1
Uncharacterized protein

1

1

High-throughput

0.479

High

908545

Q86RT5
Uncharacterized protein

1

1

Small-scale

0.451

High

233713

O45133
MADF domain-containing protein

1

1

Small-scale

0.439

High

908542

Q20384
NUCleoBindin homolog

1

5

Small-scale

0.439

High

96267

E9P875
Neurexin-3-beta

1

1

High-throughput

0.437

High

195397

O16331
Cation-transporting P-type ATPase N-terminal domain-containing protein

1

6

Small-scale

0.437

High

232455

O44490
ELKS/RAB6-interacting/CAST family member 2

1

6

High-throughput

0.437

High

908550

Q9GRZ9
Ribosome-binding protein 1

1

4

Small-scale

0.437

High

908555

Q9XU87
G-protein coupled receptors family 1 profile domain-containing protein

1

12

Small-scale

0.437

High

908556

IMMT2
MICOS complex subunit MIC60-2

1

3

Small-scale

0.437

High

908554

GBAS1
G-protein alpha subunit activating protein gbas-1

2

0

Small-scale

0.334

High

869294

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.282

High

908541

Q20178
BMERB domain-containing protein

1

0

High-throughput

0.282

High

908547

Q93930
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.282

High

111715

G5EDE8
ERGIC-53-like protein

1

0

Small-scale

0.249

Low

231959

O44191
EGF-like domain-containing protein

1

0

Small-scale

0.249

Low

234319

O45865
ADP/ATP translocase

1

0

Small-scale

0.249

Low

827132

MPCP
Phosphate carrier protein, mitochondrial

1

0

Small-scale

0.249

Low

853176

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

Small-scale

0.249

Low

908539

Q18025
Transmembrane and coiled-coil domains protein 2

1

0

Small-scale

0.249

Low

908553

Q9TZ49
Beta-sarcoglycan

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025