Protein: SMC6
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)

Gene: SMC6
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q96SB8

Gene Ontology (top 5):
GO:0000217 - DNA secondary structure binding
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000775 - chromosome, centromeric region
GO:0000781 - chromosome, telomeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1221665

SMC5
Structural maintenance of chromosomes protein 5

8

20

Small-scale

0.970

High

1261003

NSE1
Non-structural maintenance of chromosomes element 1 homolog

7

3

Small-scale

0.748

High

1302136

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

5

9

Small-scale

0.723

High

1297867

NSE3
Non-structural maintenance of chromosomes element 3 homolog

5

6

Small-scale

0.722

High

1230244

EID3
EP300-interacting inhibitor of differentiation 3

5

9

Small-scale

0.716

High

1297529

ZN597
Zinc finger protein 597

4

3

High-throughput

0.691

High

1220343

SLF2
SMC5-SMC6 complex localization factor protein 2

3

1

Small-scale

0.683

High

1297858

NSE2
E3 SUMO-protein ligase NSE2

3

5

Small-scale

0.675

High

1302131

STN1
CST complex subunit STN1

3

1

High-throughput

0.667

High

1102845

PWP3A
PWWP domain-containing DNA repair factor 3A

3

0

High-throughput

0.646

High

1237376

TSYL6
Testis-specific Y-encoded-like protein 6

2

4

High-throughput

0.628

High

1242771

SIMC1
SUMO-interacting motif-containing protein 1

2

1

High-throughput

0.628

High

1302123

SMC6
Structural maintenance of chromosomes protein 6

1

16

Small-scale

0.618

High

961248

HSF1
Heat shock factor protein 1

2

2

High-throughput

0.611

High

1019097

TP53B
TP53-binding protein 1

2

12

High-throughput

0.611

High

1245295

PJA1
E3 ubiquitin-protein ligase Praja-1

3

5

Small-scale

0.609

High

1302134

TUFT1
Tuftelin

3

1

High-throughput

0.609

High

935146

H31
Histone H3.1

2

19

High-throughput

0.584

High

231688

KIF1B
Kinesin-like protein KIF1B

1

10

High-throughput

0.536

High

591061

BTF3
Transcription factor BTF3

1

5

High-throughput

0.536

High

671003

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

2

High-throughput

0.536

High

758129

SMBP2
DNA-binding protein SMUBP-2

1

1

High-throughput

0.536

High

801325

KI67
Proliferation marker protein Ki-67

1

15

High-throughput

0.536

High

865077

TTC3
E3 ubiquitin-protein ligase TTC3

1

9

High-throughput

0.536

High

950855

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

952965

ZBED6
Zinc finger BED domain-containing protein 6

1

1

High-throughput

0.536

High

1125735

ESCO1
N-acetyltransferase ESCO1

1

4

High-throughput

0.536

High

1161787

CC174
Coiled-coil domain-containing protein 174

1

1

High-throughput

0.536

High

1238441

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

3

High-throughput

0.536

High

1264635

DGCR8
Microprocessor complex subunit DGCR8

1

1

High-throughput

0.536

High

1302124

SLF1
SMC5-SMC6 complex localization factor protein 1

1

15

High-throughput

0.536

High

1302125

IFT27
Intraflagellar transport protein 27 homolog

1

2

High-throughput

0.536

High

1302128

KLC2
Kinesin light chain 2

1

1

High-throughput

0.536

High

1302130

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.536

High

1302132

ELP3
Elongator complex protein 3

1

1

High-throughput

0.536

High

1302135

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.536

High

229468

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

18

High-throughput

0.515

High

1030117

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.515

High

1048192

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

15

High-throughput

0.515

High

815285

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.513

High

1302137

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.513

High

621618

LAMA2
Laminin subunit alpha-2

1

1

High-throughput

0.489

High

850495

PLXA3
Plexin-A3

1

3

High-throughput

0.489

High

1150470

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

2

High-throughput

0.489

High

1167878

B3GLT
Beta-1,3-glucosyltransferase

1

2

High-throughput

0.489

High

1302133

TM165
Putative divalent cation/proton antiporter TMEM165

1

1

High-throughput

0.489

High

244823

BRD4
Bromodomain-containing protein 4

1

12

High-throughput

0.479

High

385385

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.479

High

553498

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

652027

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

668923

PML
Protein PML

1

19

High-throughput

0.479

High

721225

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

749801

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.479

High

941339

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.479

High

952569

H33
Histone H3.3

1

19

High-throughput

0.479

High

1035993

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1043177

CUL4A
Cullin-4A

1

14

High-throughput

0.479

High

1056947

MDC1
Mediator of DNA damage checkpoint protein 1

1

18

High-throughput

0.479

High

1188753

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1286448

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1302138

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1302141

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.479

High

1302142

ALK
ALK tyrosine kinase receptor

1

19

Small-scale

0.479

High

1302143

TIM
Protein timeless homolog

1

3

Small-scale

0.479

High

1302140

TNIK
TRAF2 and NCK-interacting protein kinase

1

10

High-throughput

0.457

High

347662

MYC
Myc proto-oncogene protein

1

18

High-throughput

0.445

High

387350

P53
Cellular tumor antigen p53

1

3

High-throughput

0.445

High

323028

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.437

High

1024267

IFT88
Intraflagellar transport protein 88 homolog

1

7

High-throughput

0.437

High

1171346

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

1302129

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.437

High

1302146

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.437

High

99749

F5H6C2
Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY

1

1

High-throughput

0.407

High

429544

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.279

Low

1048370

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1302126

MAK16
Protein MAK16 homolog

1

0

High-throughput

0.279

Low

1302127

T126A
Transmembrane protein 126A

1

0

High-throughput

0.279

Low

1302139

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

1302144

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.279

Low

1302145

IFT25
Intraflagellar transport protein 25 homolog

1

0

High-throughput

0.279

Low

1302147

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024