Protein: SRBS1
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)

Gene: SRBS1, SORBS1
Organism: Homo sapiens
Interactions: 89
UniProt ID: Q9BX66

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0003779 - actin binding
GO:0005158 - insulin receptor binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337548

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.828

High

876493

AFAD
Afadin

2

20

Small-scale

0.806

High

176494

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

Small-scale

0.756

High

145988

SH2B2
SH2B adapter protein 2

2

20

Small-scale

0.754

High

279692

FLOT1
Flotillin-1

5

5

Small-scale

0.710

High

1224639

ABI1
Abl interactor 1

1

20

High-throughput

0.698

High

411490

INSR
Insulin receptor

1

20

Small-scale

0.665

High

575836

VINC
Vinculin

3

11

Small-scale

0.664

High

905065

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

982446

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

523130

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

682008

AKT1
RAC-alpha serine/threonine-protein kinase

1

10

Small-scale

0.647

High

610501

CBL
E3 ubiquitin-protein ligase CBL

3

20

Small-scale

0.640

High

209154

NCK2
Cytoplasmic protein NCK2

1

19

Small-scale

0.618

High

338935

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

385463

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

608105

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

840811

DYN2
Dynamin-2

1

20

Small-scale

0.618

High

968472

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

992492

SOS1
Son of sevenless homolog 1

1

20

Small-scale

0.618

High

1256875

PARD3
Partitioning defective 3 homolog

1

18

High-throughput

0.618

High

1314994

ZO2
Tight junction protein ZO-2

1

17

High-throughput

0.618

High

683678

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.611

High

1314992

CASS4
Cas scaffolding protein family member 4

1

20

High-throughput

0.590

High

547195

EZRI
Ezrin

2

14

High-throughput

0.584

High

1259715

FRS2
Fibroblast growth factor receptor substrate 2

1

9

Small-scale

0.573

High

960239

CDK6
Cyclin-dependent kinase 6

1

2

Small-scale

0.569

High

173992

ATX7
Ataxin-7

1

17

Small-scale

0.554

High

1262901

RT4I1
Reticulon-4-interacting protein 1, mitochondrial

2

1

High-throughput

0.553

High

1314996

TEN1
Teneurin-1

1

7

Small-scale

0.552

High

963790

INSM1
Insulinoma-associated protein 1

1

0

Small-scale

0.549

High

991866

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

9

Small-scale

0.545

High

203250

SYNJ1
Synaptojanin-1

1

20

High-throughput

0.541

High

736699

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.541

High

883192

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

6

High-throughput

0.541

High

1217586

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

20

High-throughput

0.541

High

497542

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.536

High

515501

CDK4
Cyclin-dependent kinase 4

1

2

High-throughput

0.536

High

1251911

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.536

High

1314995

PILRA
Paired immunoglobulin-like type 2 receptor alpha

1

0

High-throughput

0.518

High

1026944

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.515

High

1301353

TGS1
Trimethylguanosine synthase

1

0

High-throughput

0.513

High

1314991

SEM6A
Semaphorin-6A

1

6

Small-scale

0.508

High

881013

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

198296

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

2

High-throughput

0.479

High

347795

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

443774

VIME
Vimentin

1

15

High-throughput

0.479

High

522166

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

647238

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

684302

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

716762

CTNA1
Catenin alpha-1

1

11

High-throughput

0.479

High

717322

CTNB1
Catenin beta-1

1

5

High-throughput

0.479

High

724275

MSX2
Homeobox protein MSX-2

1

5

High-throughput

0.479

High

781978

PERI
Peripherin

1

15

High-throughput

0.479

High

823484

PAXI
Paxillin

1

11

High-throughput

0.479

High

840570

VASP
Vasodilator-stimulated phosphoprotein

1

17

High-throughput

0.479

High

892005

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.479

High

896813

ARP3
Actin-related protein 3

1

20

High-throughput

0.479

High

909979

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

927478

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

932362

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.479

High

940549

CXAR
Coxsackievirus and adenovirus receptor

1

5

High-throughput

0.479

High

957924

EFNB1
Ephrin-B1

1

4

Small-scale

0.479

High

965825

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.479

High

1030462

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

1034771

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

20

Small-scale

0.479

High

1059356

CASP8
Caspase-8

1

4

Small-scale

0.479

High

1066628

KIF14
Kinesin-like protein KIF14

1

14

High-throughput

0.479

High

1078650

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.479

High

1080768

ZYX
Zyxin

1

18

High-throughput

0.479

High

1081141

CCDC6
Coiled-coil domain-containing protein 6

1

20

High-throughput

0.479

High

1168668

SYNE3
Nesprin-3

1

20

High-throughput

0.479

High

1172737

CE128
Centrosomal protein of 128 kDa

1

16

High-throughput

0.479

High

1192517

CNTRL
Centriolin

1

19

High-throughput

0.479

High

1243914

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

1254251

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

1256756

FBF1
Fas-binding factor 1

1

20

High-throughput

0.479

High

1291694

BICD1
Protein bicaudal D homolog 1

1

19

High-throughput

0.479

High

1310117

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

1314993

LATS2
Serine/threonine-protein kinase LATS2

1

12

High-throughput

0.479

High

1314997

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

2

High-throughput

0.479

High

166300

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

791938

HD
Huntingtin

1

5

High-throughput

0.457

High

1155935

Q6NSK7
RIN3 protein

1

20

High-throughput

0.457

High

378156

PRIO
Major prion protein

1

1

High-throughput

0.445

High

1298047

CEP63
Centrosomal protein of 63 kDa

1

18

High-throughput

0.445

High

101143

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1146169

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.437

High

447835

P3
P3 protein

1

0

High-throughput

0.282

High


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Last updated: 15 Jul 2024