Protein: NSD3
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)

Gene: NSD3
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q9BZ95

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription
GO:0032259 - methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

935205

H31
Histone H3.1

6

20

Small-scale

0.934

High

917879

H4
Histone H4

2

11

Small-scale

0.768

High

261003

H2AY
Core histone macro-H2A.1

2

20

Small-scale

0.754

High

918663

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

244897

BRD4
Bromodomain-containing protein 4

9

20

Small-scale

0.752

High

1086307

H31T
Histone H3.1t

1

20

Small-scale

0.710

High

1087385

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.691

High

800517

CBX5
Chromobox protein homolog 5

3

20

High-throughput

0.669

High

1115577

GLYR1
Cytokine-like nuclear factor N-PAC

1

7

High-throughput

0.656

High

1157224

H3C
Histone H3.3C

1

20

High-throughput

0.656

High

631576

BRD2
Bromodomain-containing protein 2

3

20

High-throughput

0.656

High

370371

ESR1
Estrogen receptor

3

20

High-throughput

0.654

High

1317717

NSD3
Histone-lysine N-methyltransferase NSD3

1

17

High-throughput

0.647

High

707738

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

828367

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

952607

H33
Histone H3.3

1

20

High-throughput

0.618

High

1244475

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1288292

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.618

High

1027243

CBX3
Chromobox protein homolog 3

2

20

High-throughput

0.614

High

1239580

KDM1B
Lysine-specific histone demethylase 2

2

8

Small-scale

0.611

High

360377

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

17

High-throughput

0.601

High

347824

MYC
Myc proto-oncogene protein

2

13

Small-scale

0.595

High

1067123

BRD3
Bromodomain-containing protein 3

2

20

High-throughput

0.584

High

988127

RAD51
DNA repair protein RAD51 homolog 1

1

3

High-throughput

0.582

High

1031605

ATM
Serine-protein kinase ATM

1

8

High-throughput

0.582

High

312964

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.573

High

446916

HXC4
Homeobox protein Hox-C4

1

8

High-throughput

0.573

High

781812

MNDA
Myeloid cell nuclear differentiation antigen

1

4

High-throughput

0.573

High

1317724

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.573

High

1171583

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.553

High

331334

CHK2
Serine/threonine-protein kinase Chk2

1

2

High-throughput

0.541

High

682013

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

High-throughput

0.541

High

790870

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

16

High-throughput

0.541

High

973877

PAX2
Paired box protein Pax-2

1

9

High-throughput

0.541

High

1059360

CASP8
Caspase-8

1

2

High-throughput

0.541

High

1282033

TRI63
E3 ubiquitin-protein ligase TRIM63

1

15

High-throughput

0.541

High

1317504

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

317509

YETS4
YEATS domain-containing protein 4

1

4

High-throughput

0.536

High

912189

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

3

High-throughput

0.536

High

949878

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.536

High

994324

DHX9
ATP-dependent RNA helicase A

1

7

High-throughput

0.536

High

175403

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.518

High

351451

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.518

High

921965

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.515

High

349620

RASH
GTPase HRas

1

6

High-throughput

0.515

High

740056

TGFR2
TGF-beta receptor type-2

1

1

High-throughput

0.515

High

1158892

Q6P2C6
MLLT6 protein

1

11

High-throughput

0.515

High

1191560

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.515

High

1317731

V9HWG0
Epididymis luminal protein 25

1

20

High-throughput

0.515

High

781220

ETV3
ETS translocation variant 3

1

20

High-throughput

0.508

High

930378

UBC9
SUMO-conjugating enzyme UBC9

1

4

High-throughput

0.508

High

971335

H11
Histone H1.1

1

18

High-throughput

0.508

High

1297822

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

12

High-throughput

0.508

High

443242

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.501

High

782199

SOX3
Transcription factor SOX-3

1

20

High-throughput

0.501

High

989547

SOX4
Transcription factor SOX-4

1

20

High-throughput

0.501

High

1075249

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.501

High

1317718

GLIS2
Zinc finger protein GLIS2

1

4

High-throughput

0.501

High

275601

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

15

High-throughput

0.494

High

608110

FGFR4
Fibroblast growth factor receptor 4

1

6

High-throughput

0.494

High

1255680

RBCC1
RB1-inducible coiled-coil protein 1

1

15

High-throughput

0.494

High

1307177

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.486

High

876619

AF17
Protein AF-17

1

10

High-throughput

0.481

High

1238244

ZN557
Zinc finger protein 557

1

5

High-throughput

0.481

High

154053

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

551573

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.480

High

122981

MEN1
Menin

1

5

High-throughput

0.479

High

179804

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

12

High-throughput

0.479

High

236828

CCNT1
Cyclin-T1

1

3

Small-scale

0.479

High

239399

CC14B
Dual specificity protein phosphatase CDC14B

1

12

High-throughput

0.479

High

257521

CREST
Calcium-responsive transactivator

1

10

Small-scale

0.479

High

309036

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.479

High

455840

PARP1
Poly [ADP-ribose] polymerase 1

1

20

High-throughput

0.479

High

595392

LMNB1
Lamin-B1

1

16

High-throughput

0.479

High

601355

VDAC1
Voltage-dependent anion-selective channel protein 1

1

2

High-throughput

0.479

High

603873

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

2

High-throughput

0.479

High

652982

APEX1
DNA repair nuclease/redox regulator APEX1

1

6

High-throughput

0.479

High

750453

COIL
Coilin

1

5

High-throughput

0.479

High

808897

YAP1
Transcriptional coactivator YAP1

1

18

High-throughput

0.479

High

846864

SMCA2
Probable global transcription activator SNF2L2

1

20

Small-scale

0.479

High

847072

SMCA4
Transcription activator BRG1

1

20

Small-scale

0.479

High

916833

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

982458

1433F
14-3-3 protein eta

1

13

High-throughput

0.479

High

1017344

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

Small-scale

0.479

High

1042472

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1118886

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

Small-scale

0.479

High

1123391

BRDT
Bromodomain testis-specific protein

1

20

High-throughput

0.479

High

1188822

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

1201901

TAXB1
Tax1-binding protein 1

1

10

High-throughput

0.479

High

1221713

SMC5
Structural maintenance of chromosomes protein 5

1

10

High-throughput

0.479

High

1239164

ZBT38
Zinc finger and BTB domain-containing protein 38

1

7

Small-scale

0.479

High

1244240

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

13

Small-scale

0.479

High

1256375

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

1260821

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

2

Small-scale

0.479

High

1269544

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1272933

SMRC1
SWI/SNF complex subunit SMARCC1

1

15

Small-scale

0.479

High

1317719

BRD9
Bromodomain-containing protein 9

1

19

Small-scale

0.479

High

1317720

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

20

Small-scale

0.479

High

1317721

ANLN
Anillin

1

1

High-throughput

0.479

High

1317722

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

6

High-throughput

0.479

High

1317725

NUP50
Nuclear pore complex protein Nup50

1

5

High-throughput

0.479

High

1317727

ASF1A
Histone chaperone ASF1A

1

4

High-throughput

0.479

High

1317729

ZN330
Zinc finger protein 330

1

6

High-throughput

0.479

High

505676

EPB41
Protein 4.1

1

1

High-throughput

0.470

High

609515

FGFR3
Fibroblast growth factor receptor 3

1

6

High-throughput

0.470

High

1049011

SEPT6
Septin-6

1

5

High-throughput

0.464

High

500874

CLUS
Clusterin

1

1

High-throughput

0.457

High

1148357

ZNF57
Zinc finger protein 57

1

2

High-throughput

0.457

High

101152

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

922362

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.437

High

1217247

CCD71
Coiled-coil domain-containing protein 71

1

3

Small-scale

0.437

High

1317723

CRNN
Cornulin

1

7

Small-scale

0.437

High

1317728

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.279

Low

1317730

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1298511

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.265

Low

1317726

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024