Protein: SPN90
NCK-interacting protein with SH3 domain (54 kDa VacA-interacting protein) (54 kDa vimentin-interacting protein) (VIP54) (90 kDa SH3 protein interacting with Nck) (AF3p21) (Dia-interacting protein 1) (DIP-1) (Diaphanous protein-interacting protein) (SH3 adapter protein SPIN90) (WASP-interacting SH3-domain protein) (WISH) (Wiskott-Aldrich syndrome protein-interacting protein)

Gene: SPN90, NCKIPSD
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9NZQ3

Gene Ontology (top 5):
GO:0000147 - actin cortical patch assembly
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005882 - intermediate filament
GO:0006897 - endocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

924910

GRB2
Growth factor receptor-bound protein 2

5

5

Small-scale

0.941

High

209182

NCK2
Cytoplasmic protein NCK2

5

5

High-throughput

0.933

High

1349371

BAIP2
BAR/IMD domain-containing adapter protein 2

4

3

Small-scale

0.905

High

557810

NCK1
SH2/SH3 adapter protein NCK1

3

5

Small-scale

0.882

High

1303976

STAC
SH3 and cysteine-rich domain-containing protein

3

7

High-throughput

0.853

High

1049739

ARHG7
Rho guanine nucleotide exchange factor 7

2

3

High-throughput

0.811

High

1066054

ARHG6
Rho guanine nucleotide exchange factor 6

2

3

High-throughput

0.811

High

1078920

ITSN1
Intersectin-1

2

4

High-throughput

0.811

High

1349276

ITSN2
Intersectin-2

2

4

High-throughput

0.811

High

1349372

GIT1
ARF GTPase-activating protein GIT1

2

1

High-throughput

0.811

High

1348414

ABI2
Abl interactor 2

2

6

High-throughput

0.783

High

581065

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

0

High-throughput

0.770

High

412383

FYN
Tyrosine-protein kinase Fyn

2

1

High-throughput

0.743

High

235606

VINEX
Vinexin

1

4

High-throughput

0.740

High

1050166

GIT2
ARF GTPase-activating protein GIT2

2

2

High-throughput

0.726

High

1316298

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.698

High

905192

1433G
14-3-3 protein gamma

3

5

High-throughput

0.667

High

862113

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.656

High

157778

GEMI2
Gem-associated protein 2

3

0

High-throughput

0.646

High

1263371

GEMI6
Gem-associated protein 6

3

0

High-throughput

0.646

High

1263193

PALLD
Palladin

3

0

Small-scale

0.638

High

1347573

GEMI8
Gem-associated protein 8

3

0

High-throughput

0.638

High

242950

GAS7
Growth arrest-specific protein 7

4

2

High-throughput

0.638

High

927595

1433Z
14-3-3 protein zeta/delta

2

5

High-throughput

0.628

High

1242580

RB15B
Putative RNA-binding protein 15B

2

1

High-throughput

0.628

High

1261050

SNX33
Sorting nexin-33

2

2

High-throughput

0.628

High

1302713

RBM15
RNA-binding protein 15

2

1

High-throughput

0.628

High

1349364

EP15R
Epidermal growth factor receptor substrate 15-like 1

2

2

High-throughput

0.628

High

337574

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.618

High

802756

CRK
Adapter molecule crk

1

7

High-throughput

0.618

High

682045

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.614

High

131669

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

2

0

High-throughput

0.602

High

313573

ZFYV9
Zinc finger FYVE domain-containing protein 9

2

0

High-throughput

0.602

High

822182

KC1A
Casein kinase I isoform alpha

2

0

High-throughput

0.602

High

910101

1433E
14-3-3 protein epsilon

2

0

High-throughput

0.602

High

1349367

DACH1
Dachshund homolog 1

2

0

High-throughput

0.602

High

122241

PSMD9
26S proteasome non-ATPase regulatory subunit 9

2

0

High-throughput

0.601

High

149371

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.586

High

1343720

ANLN
Anillin

1

0

High-throughput

0.586

High

448836

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

880595

LEG4
Galectin-4

2

0

High-throughput

0.580

High

1038076

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.580

High

1048570

VEZF1
Vascular endothelial zinc finger 1

2

0

High-throughput

0.580

High

1174972

MED25
Mediator of RNA polymerase II transcription subunit 25

2

0

High-throughput

0.580

High

1263040

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

0

High-throughput

0.580

High

1291384

CPNE2
Copine-2

2

0

High-throughput

0.580

High

1300704

RET7
Retinoid-binding protein 7

2

0

High-throughput

0.580

High

1307396

PKP2
Plakophilin-2

2

0

High-throughput

0.580

High

1312893

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.580

High

1347088

RBM22
Pre-mRNA-splicing factor RBM22

2

0

High-throughput

0.580

High

1349365

ZBT47
Zinc finger and BTB domain-containing protein 47

2

0

High-throughput

0.580

High

1203307

FCSD1
F-BAR and double SH3 domains protein 1

2

4

High-throughput

0.574

High

1345635

DIAP3
Protein diaphanous homolog 3

1

0

Small-scale

0.549

High

647331

1433T
14-3-3 protein theta

1

5

High-throughput

0.536

High

683764

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.536

High

896985

ARP2
Actin-related protein 2

1

2

High-throughput

0.536

High

982558

1433F
14-3-3 protein eta

1

5

High-throughput

0.536

High

1040526

SNX1
Sorting nexin-1

1

1

High-throughput

0.536

High

1052337

SRC8
Src substrate cortactin

1

7

High-throughput

0.536

High

1349369

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

5

High-throughput

0.536

High

884096

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.530

High

1084923

SMN
Survival motor neuron protein

1

0

High-throughput

0.530

High

1349366

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.530

High

388770

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

319068

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

402557

JUN
Transcription factor Jun

1

0

High-throughput

0.513

High

414087

GELS
Gelsolin

1

0

High-throughput

0.513

High

587031

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

809459

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

813187

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

903043

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.513

High

930030

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.513

High

974161

DYST
Dystonin

1

0

High-throughput

0.513

High

1216849

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

1256686

GEMI5
Gem-associated protein 5

1

0

High-throughput

0.513

High

1302137

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.513

High

1333347

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

1349370

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.513

High

1349362

ARP3B
Actin-related protein 3B

1

2

High-throughput

0.489

High

815715

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

Small-scale

0.480

High

1297725

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.460

High

163393

XPO1
Exportin-1

1

0

High-throughput

0.458

High

925678

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

Small-scale

0.458

High

1066794

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1172041

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1269789

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1270480

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1272652

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.426

High

991903

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

Small-scale

0.391

High

1310348

PDD2L
Programmed cell death protein 2-like

2

0

High-throughput

0.328

High

1315232

RFIP5
Rab11 family-interacting protein 5

2

0

High-throughput

0.328

High

1346476

FBX28
F-box only protein 28

2

0

High-throughput

0.328

High

1120656

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

1191933

SEN54
tRNA-splicing endonuclease subunit Sen54

2

0

High-throughput

0.316

High

1217951

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1327837

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1349368

PS1C2
Psoriasis susceptibility 1 candidate gene 2 protein

2

0

High-throughput

0.316

High

1345394

CLTR2
Cysteinyl leukotriene receptor 2

1

0

High-throughput

0.282

High

1345525

RL3R1
Relaxin-3 receptor 1

1

0

High-throughput

0.282

High

1133134

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.279

Low

101238

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1088685

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

1174122

UBP54
Inactive ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

1230189

CNTRB
Centrobin

1

0

High-throughput

0.249

Low

1335210

RC3H2
Roquin-2

1

0

High-throughput

0.249

Low

1349363

JCAD
Junctional cadherin 5-associated protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024