Protein: HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2)

Gene: HCN2
Organism: Homo sapiens
Interactions: 13
UniProt ID: Q9UL51

Gene Ontology (top 5):
GO:0003254 - regulation of membrane depolarization
GO:0005222 - intracellularly cAMP-activated cation channel activity
GO:0005248 - voltage-gated sodium channel activity
GO:0005249 - voltage-gated potassium channel activity
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

255280

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

3

13

Small-scale

0.821

High

1461457

HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

2

13

Small-scale

0.808

High

1461458

HCN4
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

2

14

Small-scale

0.789

High

1461459

KCNE2
Potassium voltage-gated channel subfamily E member 2

1

2

Small-scale

0.621

High

557516

SRC
Proto-oncogene tyrosine-protein kinase Src

2

8

Small-scale

0.584

High

1432448

TTYH1
Protein tweety homolog 1

1

2

High-throughput

0.536

High

362405

ABL1
Tyrosine-protein kinase ABL1

1

8

High-throughput

0.479

High

440779

FYN
Tyrosine-protein kinase Fyn

1

8

High-throughput

0.479

High

988019

GRB2
Growth factor receptor-bound protein 2

1

9

High-throughput

0.479

High

1045896

TF65
Transcription factor p65

1

2

High-throughput

0.479

High

573719

ENPL
Endoplasmin

1

2

High-throughput

0.470

High

106837

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High


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Last updated: 11Aug2025