Protein: M3K1
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)

Gene: M3K1, MAP3K1
Organism: Homo sapiens
Interactions: 237
UniProt ID: Q13233

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800980

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

11

20

Small-scale

0.982

High

800771

MK08
Mitogen-activated protein kinase 8

5

20

Small-scale

0.928

High

167534

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

5

20

Small-scale

0.926

High

170647

AXIN1
Axin-1

5

9

Small-scale

0.902

High

158460

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

3

20

Small-scale

0.896

High

658925

MK01
Mitogen-activated protein kinase 1

4

20

Small-scale

0.893

High

900435

RHOA
Transforming protein RhoA

4

20

Small-scale

0.891

High

972188

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

4

19

Small-scale

0.886

High

1028368

M3K1
Mitogen-activated protein kinase kinase kinase 1

3

14

Small-scale

0.861

High

153119

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

3

20

Small-scale

0.834

High

374163

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

11

Small-scale

0.819

High

1018152

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

2

20

Small-scale

0.789

High

542875

BRAF
Serine/threonine-protein kinase B-raf

2

14

Small-scale

0.768

High

800880

MK09
Mitogen-activated protein kinase 9

2

19

Small-scale

0.767

High

1028376

STK38
Serine/threonine-protein kinase 38

2

18

Small-scale

0.754

High

1028379

DDB1
DNA damage-binding protein 1

2

6

Small-scale

0.754

High

1026150

PAK1
Serine/threonine-protein kinase PAK 1

1

17

Small-scale

0.735

High

835718

GSK3B
Glycogen synthase kinase-3 beta

1

18

Small-scale

0.724

High

1028373

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

19

Small-scale

0.691

High

1028431

HIPK2
Homeodomain-interacting protein kinase 2

1

20

Small-scale

0.691

High

1028457

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

20

Small-scale

0.691

High

1020637

TRAF2
TNF receptor-associated factor 2

4

20

Small-scale

0.689

High

804230

NOTC1
Neurogenic locus notch homolog protein 1

1

0

Small-scale

0.687

High

902898

DCAF7
DDB1- and CUL4-associated factor 7

3

3

Small-scale

0.674

High

909513

1433E
14-3-3 protein epsilon

3

20

Small-scale

0.674

High

1028370

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

11

High-throughput

0.665

High

1028380

CDC37
Hsp90 co-chaperone Cdc37

1

10

High-throughput

0.665

High

258006

DNJB6
DnaJ homolog subfamily B member 6

1

8

Small-scale

0.647

High

259936

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

8

Small-scale

0.647

High

600566

EPHA1
Ephrin type-A receptor 1

1

3

Small-scale

0.647

High

636482

DNJB2
DnaJ homolog subfamily B member 2

1

3

Small-scale

0.647

High

639739

IKBA
NF-kappa-B inhibitor alpha

1

6

Small-scale

0.647

High

647566

MK03
Mitogen-activated protein kinase 3

1

20

Small-scale

0.647

High

872152

RD23A
UV excision repair protein RAD23 homolog A

1

14

Small-scale

0.647

High

896305

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

13

Small-scale

0.647

High

1028377

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

20

Small-scale

0.647

High

1028391

NEK10
Serine/threonine-protein kinase Nek10

1

16

Small-scale

0.647

High

1028402

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

5

Small-scale

0.647

High

1028411

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

17

Small-scale

0.647

High

1028422

UBAC1
Ubiquitin-associated domain-containing protein 1

1

1

Small-scale

0.647

High

1028446

DP13A
DCC-interacting protein 13-alpha

1

4

Small-scale

0.647

High

1028451

UBQL1
Ubiquilin-1

1

9

Small-scale

0.647

High

445779

ACM5
Muscarinic acetylcholine receptor M5

1

5

High-throughput

0.625

High

386657

P53
Cellular tumor antigen p53

2

4

Small-scale

0.624

High

924541

GRB2
Growth factor receptor-bound protein 2

2

8

Small-scale

0.624

High

521533

ACTN1
Alpha-actinin-1

1

6

Small-scale

0.621

High

241166

TOM1
Target of Myb1 membrane trafficking protein

2

6

Small-scale

0.619

High

2076

A0A0B4J269
Tubulin beta-3 chain

1

18

High-throughput

0.618

High

324800

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

Small-scale

0.618

High

384768

NTRK1
High affinity nerve growth factor receptor

1

16

High-throughput

0.618

High

431808

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

438130

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

475017

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

18

High-throughput

0.618

High

475703

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

18

Small-scale

0.618

High

681426

DNJA1
DnaJ homolog subfamily A member 1

1

10

High-throughput

0.618

High

929844

ACTG
Actin, cytoplasmic 2

1

12

High-throughput

0.618

High

1028389

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1028418

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

9

High-throughput

0.618

High

1028430

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

19

High-throughput

0.618

High

1028447

VAV3
Guanine nucleotide exchange factor VAV3

1

10

High-throughput

0.618

High

1028450

ALK
ALK tyrosine kinase receptor

1

16

Small-scale

0.618

High

930188

UBC9
SUMO-conjugating enzyme UBC9

2

14

Small-scale

0.606

High

1028409

FRAT1
Proto-oncogene FRAT1

1

0

Small-scale

0.586

High

1028388

CRTC1
CREB-regulated transcription coactivator 1

1

1

Small-scale

0.561

High

1028394

CSN6
COP9 signalosome complex subunit 6

1

4

Small-scale

0.561

High

582267

NUCL
Nucleolin

1

2

High-throughput

0.553

High

852900

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.553

High

1028374

RCN2
Reticulocalbin-2

1

9

High-throughput

0.553

High

1028449

HECD1
E3 ubiquitin-protein ligase HECTD1

1

15

High-throughput

0.553

High

1028404

BAALC
Brain and acute leukemia cytoplasmic protein

1

0

Small-scale

0.549

High

401936

JUN
Transcription factor Jun

2

6

Small-scale

0.543

High

1028417

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

Small-scale

0.541

High

159054

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

15

High-throughput

0.541

High

849319

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

12

High-throughput

0.541

High

851810

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

12

High-throughput

0.541

High

895785

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

12

High-throughput

0.541

High

919719

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

12

High-throughput

0.541

High

1028415

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

14

High-throughput

0.541

High

1028455

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

12

High-throughput

0.541

High

1028395

DTX1
E3 ubiquitin-protein ligase DTX1

1

0

Small-scale

0.537

High

133469

NOP56
Nucleolar protein 56

1

1

High-throughput

0.536

High

261250

FLNB
Filamin-B

1

14

Small-scale

0.536

High

685929

ARRB2
Beta-arrestin-2

1

5

High-throughput

0.536

High

827185

ARRB1
Beta-arrestin-1

1

5

High-throughput

0.536

High

927001

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1028385

L2GL2
LLGL scribble cell polarity complex component 2

1

2

High-throughput

0.536

High

736433

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.515

High

903916

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

7

High-throughput

0.515

High

911114

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.515

High

921834

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.515

High

63138

CCD69
Coiled-coil domain-containing protein 69

1

1

Small-scale

0.501

High

124400

HIP1
Huntingtin-interacting protein 1

1

16

Small-scale

0.501

High

159985

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

9

Small-scale

0.501

High

277057

STAM2
Signal transducing adapter molecule 2

1

11

Small-scale

0.501

High

280794

KRT36
Keratin, type I cuticular Ha6

1

9

Small-scale

0.501

High

283142

ZFAN5
AN1-type zinc finger protein 5

1

1

Small-scale

0.501

High

299365

UBXN7
UBX domain-containing protein 7

1

2

Small-scale

0.501

High

362082

MBP
Myelin basic protein

1

5

Small-scale

0.501

High

369527

ESR1
Estrogen receptor

1

8

Small-scale

0.501

High

380287

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

Small-scale

0.501

High

611432

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

7

Small-scale

0.501

High

874087

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.501

High

908257

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

7

Small-scale

0.501

High

1028369

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

13

Small-scale

0.501

High

1028375

TNIP1
TNFAIP3-interacting protein 1

1

16

Small-scale

0.501

High

1028383

GRAP1
GRIP1-associated protein 1

1

20

Small-scale

0.501

High

1028384

ODFP2
Outer dense fiber protein 2

1

19

Small-scale

0.501

High

1028386

CEP85
Centrosomal protein of 85 kDa

1

20

Small-scale

0.501

High

1028387

DCNL2
DCN1-like protein 2

1

1

Small-scale

0.501

High

1028390

TM1L2
TOM1-like protein 2

1

6

Small-scale

0.501

High

1028396

SPART
Spartin

1

6

Small-scale

0.501

High

1028401

R3GEF
Guanine nucleotide exchange factor for Rab-3A

1

3

Small-scale

0.501

High

1028406

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

Small-scale

0.501

High

1028408

STAM1
Signal transducing adapter molecule 1

1

9

Small-scale

0.501

High

1028419

DCNL1
DCN1-like protein 1

1

1

Small-scale

0.501

High

1028421

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

9

Small-scale

0.501

High

1028424

RN126
E3 ubiquitin-protein ligase RNF126

1

2

Small-scale

0.501

High

1028426

CAR14
Caspase recruitment domain-containing protein 14

1

8

Small-scale

0.501

High

1028427

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

11

Small-scale

0.501

High

1028432

RABE2
Rab GTPase-binding effector protein 2

1

20

Small-scale

0.501

High

1028433

ILRUN
Protein ILRUN

1

1

Small-scale

0.501

High

1028435

ZFAN3
AN1-type zinc finger protein 3

1

1

Small-scale

0.501

High

1028456

HBS1L
HBS1-like protein

1

7

Small-scale

0.501

High

1028458

RN114
E3 ubiquitin-protein ligase RNF114

1

15

Small-scale

0.501

High

1028459

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.501

High

180304

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.489

High

1028444

PURG
Purine-rich element-binding protein gamma

1

1

High-throughput

0.489

High

749446

BRCA1
Breast cancer type 1 susceptibility protein

1

8

High-throughput

0.481

High

957810

RHG04
Rho GTPase-activating protein 4

1

2

Small-scale

0.481

High

868167

ATX3
Ataxin-3

1

0

Small-scale

0.480

High

1028398

DEN6B
Protein DENND6B

1

0

Small-scale

0.480

High

1028400

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.480

High

1028410

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.480

High

1028436

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.480

High

1028438

UBAP1
Ubiquitin-associated protein 1

1

0

Small-scale

0.480

High

1028441

IMPCT
Protein IMPACT

1

0

Small-scale

0.480

High

1028442

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

Small-scale

0.480

High

1028460

EPN1
Epsin-1

1

0

Small-scale

0.480

High

150975

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

12

Small-scale

0.479

High

162696

XPO1
Exportin-1

1

6

High-throughput

0.479

High

297343

MYO1D
Unconventional myosin-Id

1

20

High-throughput

0.479

High

323730

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.479

High

325157

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

5

High-throughput

0.479

High

381186

TBB4A
Tubulin beta-4A chain

1

16

High-throughput

0.479

High

400537

RLA2
Large ribosomal subunit protein P2

1

3

High-throughput

0.479

High

428180

TBB5
Tubulin beta chain

1

17

High-throughput

0.479

High

443489

VIME
Vimentin

1

9

High-throughput

0.479

High

448332

GSTP1
Glutathione S-transferase P

1

5

Small-scale

0.479

High

502050

BIP
Endoplasmic reticulum chaperone BiP

1

17

High-throughput

0.479

High

504016

HSP7C
Heat shock cognate 71 kDa protein

1

13

High-throughput

0.479

High

564068

HSP76
Heat shock 70 kDa protein 6

1

14

High-throughput

0.479

High

573242

TCPA
T-complex protein 1 subunit alpha

1

14

High-throughput

0.479

High

574318

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.479

High

575036

RL7
Large ribosomal subunit protein uL30

1

1

High-throughput

0.479

High

598097

FLNA
Filamin-A

1

14

High-throughput

0.479

High

639580

TNR5
Tumor necrosis factor receptor superfamily member 5

1

4

Small-scale

0.479

High

642324

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.479

High

646860

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

649487

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

653243

PYR1
Multifunctional protein CAD

1

5

High-throughput

0.479

High

713957

HS71L
Heat shock 70 kDa protein 1-like

1

13

High-throughput

0.479

High

725153

MYH10
Myosin-10

1

14

High-throughput

0.479

High

751609

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

760034

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

770813

TCPZ
T-complex protein 1 subunit zeta

1

14

High-throughput

0.479

High

788826

RS27
Small ribosomal subunit protein eS27

1

6

High-throughput

0.479

High

790385

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

806840

RS9
Small ribosomal subunit protein uS4

1

2

High-throughput

0.479

High

821191

TCPE
T-complex protein 1 subunit epsilon

1

17

High-throughput

0.479

High

825938

FAS
Fatty acid synthase

1

4

High-throughput

0.479

High

826642

TCPG
T-complex protein 1 subunit gamma

1

14

High-throughput

0.479

High

832420

MCM2
DNA replication licensing factor MCM2

1

10

High-throughput

0.479

High

842481

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.479

High

842852

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.479

High

843182

TCPD
T-complex protein 1 subunit delta

1

14

High-throughput

0.479

High

875955

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.479

High

880100

SYMC
Methionine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

885240

EPIPL
Epiplakin

1

12

High-throughput

0.479

High

900144

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.479

High

904518

1433G
14-3-3 protein gamma

1

20

Small-scale

0.479

High

907300

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.479

High

907885

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.479

High

910401

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

910672

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.479

High

911364

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.479

High

911821

RUXF
Small nuclear ribonucleoprotein F

1

3

High-throughput

0.479

High

914952

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.479

High

916555

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

922543

RL10A
Large ribosomal subunit protein uL1

1

3

High-throughput

0.479

High

957573

PKD1
Polycystin-1

1

2

Small-scale

0.479

High

984341

EF1A2
Elongation factor 1-alpha 2

1

7

High-throughput

0.479

High

989779

RL18
Large ribosomal subunit protein eL18

1

2

High-throughput

0.479

High

994144

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.479

High

1028371

CUL4A
Cullin-4A

1

6

Small-scale

0.479

High

1028372

CUL4B
Cullin-4B

1

6

Small-scale

0.479

High

1028381

TBB8
Tubulin beta-8 chain

1

17

High-throughput

0.479

High

1028392

TBA1A
Tubulin alpha-1A chain

1

9

High-throughput

0.479

High

1028407

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

1028413

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

6

High-throughput

0.479

High

1028423

TBB6
Tubulin beta-6 chain

1

17

High-throughput

0.479

High

1028425

TBB2B
Tubulin beta-2B chain

1

17

High-throughput

0.479

High

1028428

TRIM5
Tripartite motif-containing protein 5

1

6

Small-scale

0.479

High

1028443

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1028448

BAG5
BAG family molecular chaperone regulator 5

1

3

High-throughput

0.479

High

1028452

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.479

High

1028453

Q9UQC1
Heat shock protein 72

1

19

High-throughput

0.479

High

1028454

RUVB2
RuvB-like 2

1

2

High-throughput

0.479

High

151783

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.458

High

335099

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

883982

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

949457

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

1028412

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.458

High

1028397

F184A
Protein FAM184A

1

18

Small-scale

0.457

High

1028403

RN141
RING finger protein 141

1

1

Small-scale

0.457

High

1028416

FAF2
FAS-associated factor 2

1

2

Small-scale

0.457

High

1028420

CREL1
Protein disulfide isomerase CRELD1

1

4

Small-scale

0.457

High

1028445

GGA2
ADP-ribosylation factor-binding protein GGA2

1

5

Small-scale

0.457

High

346687

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.445

High

397370

ADT2
ADP/ATP translocase 2

1

5

High-throughput

0.437

High

518335

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.437

High

778131

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

802081

NOP2
Probable 28S rRNA

1

3

High-throughput

0.437

High

847258

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.437

High

917207

H4
Histone H4

1

5

High-throughput

0.437

High

995356

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.437

High

1028378

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.437

High

1028382

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.437

High

1028393

RS27L
Ribosomal protein eS27-like

1

6

High-throughput

0.437

High

1028399

RLA0L
Putative ribosomal protein uL10-like

1

3

High-throughput

0.437

High

1028405

DDB2
DNA damage-binding protein 2

1

9

Small-scale

0.437

High

1028439

HPBP1
Hsp70-binding protein 1

1

1

High-throughput

0.437

High

1028440

MYOF
Myoferlin

1

3

High-throughput

0.437

High

1028414

R51A1
RAD51-associated protein 1

1

0

Small-scale

0.261

Low

1028429

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

Small-scale

0.261

Low

1028434

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

Small-scale

0.261

Low

1028437

CUED1
CUE domain-containing protein 1

1

0

Small-scale

0.261

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024