Protein: PFD6
Prefoldin subunit 6 (Protein Ke2)

Gene: PFD6, PFDN6
Organism: Homo sapiens
Interactions: 157
UniProt ID: O15212

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0016272 - prefoldin complex
GO:0050821 - protein stabilization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

171597

PFD3
Prefoldin subunit 3

5

2

High-throughput

0.927

High

171681

PFD4
Prefoldin subunit 4

5

2

High-throughput

0.927

High

171692

UXT
Protein UXT

5

3

Small-scale

0.927

High

171565

RMP
Unconventional prefoldin RPB5 interactor 1

5

5

Small-scale

0.915

High

171667

PFD5
Prefoldin subunit 5

4

4

Small-scale

0.881

High

171560

PFD1
Prefoldin subunit 1

3

1

High-throughput

0.861

High

171695

PFD2
Prefoldin subunit 2

3

2

High-throughput

0.861

High

171682

PDRG1
p53 and DNA damage-regulated protein 1

3

0

High-throughput

0.803

High

171675

RPAP3
RNA polymerase II-associated protein 3

6

0

Small-scale

0.699

High

171584

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

2

High-throughput

0.694

High

171598

DCAF7
DDB1- and CUL4-associated factor 7

3

7

High-throughput

0.671

High

171600

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

3

2

Small-scale

0.671

High

171603

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3

6

High-throughput

0.667

High

171665

DCAF5
DDB1- and CUL4-associated factor 5

3

6

High-throughput

0.667

High

171674

SKI8
Superkiller complex protein 8

3

6

High-throughput

0.667

High

171614

MK07
Mitogen-activated protein kinase 7

4

0

High-throughput

0.661

High

171644

TBA1A
Tubulin alpha-1A chain

3

5

High-throughput

0.643

High

171694

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

3

0

High-throughput

0.638

High

171577

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

1

High-throughput

0.628

High

171688

PIHD1
PIH1 domain-containing protein 1

3

0

Small-scale

0.628

High

169736

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

1

High-throughput

0.611

High

171686

RPC2
DNA-directed RNA polymerase III subunit RPC2

2

4

High-throughput

0.611

High

171701

RUVB2
RuvB-like 2

2

2

High-throughput

0.611

High

171617

HDAC1
Histone deacetylase 1

2

0

High-throughput

0.602

High

171588

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.586

High

171616

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

2

5

High-throughput

0.584

High

171656

POC1B
POC1 centriolar protein homolog B

2

6

High-throughput

0.584

High

171557

MAGB4
Melanoma-associated antigen B4

2

0

High-throughput

0.580

High

171567

MBD3
Methyl-CpG-binding domain protein 3

2

0

High-throughput

0.580

High

171631

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.580

High

171696

FBX2
F-box only protein 2

2

0

High-throughput

0.580

High

171580

TBG1
Tubulin gamma-1 chain

2

4

High-throughput

0.571

High

171666

DAA10
Dynein axonemal assembly factor 10

2

0

High-throughput

0.559

High

171566

RPA1
DNA-directed RNA polymerase I subunit RPA1

2

3

High-throughput

0.558

High

171622

RBBP7
Histone-binding protein RBBP7

2

5

High-throughput

0.558

High

171590

CEBPG
CCAAT/enhancer-binding protein gamma

2

1

High-throughput

0.553

High

171576

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.547

High

153039

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.536

High

171586

GRK6
G protein-coupled receptor kinase 6

1

1

High-throughput

0.536

High

171593

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.536

High

171606

TBA1B
Tubulin alpha-1B chain

1

5

High-throughput

0.536

High

171608

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.536

High

171623

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.536

High

171639

KSR2
Kinase suppressor of Ras 2

1

2

High-throughput

0.536

High

171645

STRAA
STE20-related kinase adapter protein alpha

1

1

High-throughput

0.536

High

171702

RUVB1
RuvB-like 1

1

2

High-throughput

0.536

High

171615

ERCC8
DNA excision repair protein ERCC-8

2

7

Small-scale

0.533

High

171635

TBA3E
Tubulin alpha-3E chain

1

4

High-throughput

0.515

High

171691

WRP73
WD repeat-containing protein WRAP73

1

8

High-throughput

0.515

High

171564

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.513

High

171619

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

171625

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

0

High-throughput

0.513

High

171647

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.513

High

171699

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.493

High

134760

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.489

High

171579

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

1

High-throughput

0.489

High

171582

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

4

High-throughput

0.489

High

171601

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

High-throughput

0.489

High

171626

PCGF3
Polycomb group RING finger protein 3

1

1

High-throughput

0.489

High

171627

DC4L1
DDB1- and CUL4-associated factor 4-like protein 1

1

1

High-throughput

0.489

High

148017

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

4

High-throughput

0.479

High

155961

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

3

High-throughput

0.479

High

171569

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

171570

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

171574

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

171592

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

171594

ARP3
Actin-related protein 3

1

3

High-throughput

0.479

High

171595

ACTZ
Alpha-centractin

1

2

High-throughput

0.479

High

171605

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

171607

TBA4A
Tubulin alpha-4A chain

1

5

High-throughput

0.479

High

171629

DCAF6
DDB1- and CUL4-associated factor 6

1

8

High-throughput

0.479

High

171636

SKI3
Superkiller complex protein 3

1

1

High-throughput

0.479

High

171650

WDTC1
WD and tetratricopeptide repeats protein 1

1

6

High-throughput

0.479

High

171652

POC1A
POC1 centriolar protein homolog A

1

7

High-throughput

0.479

High

171671

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

5

High-throughput

0.479

High

171703

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.479

High

171558

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

5

High-throughput

0.470

High

125005

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

171568

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

171571

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

171585

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

171604

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.458

High

171609

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

171610

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

171618

CUL3
Cullin-3

1

0

High-throughput

0.458

High

171621

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

171630

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

171641

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

171643

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

171660

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

171661

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.458

High

171662

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.458

High

171668

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

0

High-throughput

0.458

High

171669

DUS9
Dual specificity protein phosphatase 9

1

0

High-throughput

0.458

High

171676

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

171693

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

171562

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

1

High-throughput

0.437

High

171572

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

171599

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.437

High

171611

TLE2
Transducin-like enhancer protein 2

1

5

High-throughput

0.437

High

171612

RON
Macrophage-stimulating protein receptor

1

1

High-throughput

0.437

High

171620

SKI2
Superkiller complex protein 2

1

1

High-throughput

0.437

High

171634

CDC73
Parafibromin

1

1

High-throughput

0.437

High

171637

TTC33
Tetratricopeptide repeat protein 33

1

1

High-throughput

0.437

High

171638

WDR82
WD repeat-containing protein 82

1

6

High-throughput

0.437

High

171646

WDR53
WD repeat-containing protein 53

1

6

High-throughput

0.437

High

171648

FBXW8
F-box/WD repeat-containing protein 8

1

4

High-throughput

0.437

High

171653

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.437

High

171654

COP1
E3 ubiquitin-protein ligase COP1

1

7

High-throughput

0.437

High

171658

DCA11
DDB1- and CUL4-associated factor 11

1

6

High-throughput

0.437

High

171659

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

171663

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.437

High

171670

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

6

High-throughput

0.437

High

171677

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

4

High-throughput

0.437

High

171683

DCA13
DDB1- and CUL4-associated factor 13

1

4

High-throughput

0.437

High

171689

WSB2
WD repeat and SOCS box-containing protein 2

1

7

High-throughput

0.437

High

171690

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

1

High-throughput

0.437

High

171697

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.437

High

171698

ALK
ALK tyrosine kinase receptor

1

1

High-throughput

0.437

High

171700

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.437

High

171704

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.437

High

112035

ASURF
ASNSD1 upstream open reading frame protein

1

0

High-throughput

0.426

High

171587

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

171685

RPC5
DNA-directed RNA polymerase III subunit RPC5

2

0

High-throughput

0.318

High

171613

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

0

High-throughput

0.316

High

171657

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.316

High

171672

KIFC3
Kinesin-like protein KIFC3

2

0

High-throughput

0.316

High

171680

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

0

High-throughput

0.316

High

171649

ARG39
Rho guanine nucleotide exchange factor 39

2

0

High-throughput

0.298

High

171559

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.282

High

171561

KI21B
Kinesin-like protein KIF21B

1

0

High-throughput

0.279

Low

171589

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.279

Low

171591

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.279

Low

171628

KR133
Keratin-associated protein 13-3

1

0

High-throughput

0.279

Low

171642

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.279

Low

171651

DB123
Beta-defensin 123

1

0

High-throughput

0.279

Low

171655

UHMK1
Serine/threonine-protein kinase Kist

1

0

High-throughput

0.279

Low

171578

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

171664

THA11
THAP domain-containing protein 11

1

0

Small-scale

0.265

Low

171556

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.249

Low

171563

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.249

Low

171573

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.249

Low

171581

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

171583

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

171596

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low

171602

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.249

Low

171624

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

0

High-throughput

0.249

Low

171632

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

171633

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

171673

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.249

Low

171678

RC3H2
Roquin-2

1

0

High-throughput

0.249

Low

171684

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.249

Low

171687

ASND1
Asparagine synthetase domain-containing protein 1

1

0

High-throughput

0.249

Low

171705

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.249

Low

171575

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low

171640

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

171679

RAB18
Ras-related protein Rab-18

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024