Protein: SPK1
Serine/threonine-protein kinase spk-1 (EC 2.7.11.1)

Gene: SPK1, spk-1
Organism: Caenorhabditis elegans
Interactions: 49
UniProt ID: Q03563

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

113076

BIR1
Chromosomal passenger complex protein bir-1

2

3

High-throughput

0.743

High

933089

LIN2
Protein lin-2

2

9

High-throughput

0.743

High

1043400

JAC1
Juxtamembrane domain-associated catenin

2

13

High-throughput

0.743

High

264031

PRY1
Axin-like protein pry-1

2

0

High-throughput

0.705

High

1043383

HSP90
Heat shock protein 90

1

20

High-throughput

0.698

High

1043398

RSP3
Probable splicing factor, arginine/serine-rich 3

1

20

Small-scale

0.647

High

145041

O01686
Oxysterol-binding protein

1

3

High-throughput

0.625

High

1043381

PAR3
Partitioning defective protein 3

2

12

High-throughput

0.594

High

233492

O44781
RNA helicase

2

20

High-throughput

0.576

High

759648

IF5A1
Eukaryotic translation initiation factor 5A-1

2

2

High-throughput

0.576

High

1019135

P91457
RanBP2-type domain-containing protein

2

10

High-throughput

0.576

High

1043384

SYFB
Phenylalanine--tRNA ligase beta subunit

2

1

High-throughput

0.576

High

1043385

APC11
Anaphase-promoting complex subunit 11

2

1

High-throughput

0.576

High

1043386

APR1
Adenomatous polyposis coli protein-related protein 1

2

2

High-throughput

0.576

High

1043388

Q22137
1,4-alpha-glucan branching enzyme

2

2

High-throughput

0.576

High

1043391

PSA2
Proteasome subunit alpha type-2

2

6

High-throughput

0.576

High

1043396

Q95Y13
Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein

2

1

High-throughput

0.576

High

1043397

SEC13
Protein SEC13 homolog

2

19

High-throughput

0.576

High

110809

TACC1
Transforming acid coiled-coil-containing protein 1

2

0

High-throughput

0.551

High

1043387

Q22078
Nuclear pore complex protein Nup85

2

0

High-throughput

0.551

High

233940

NH111
Nuclear hormone receptor family member nhr-111

1

20

High-throughput

0.541

High

914923

CLP1
Protein clpf-1

1

1

High-throughput

0.541

High

1018981

P91306
CSD domain-containing protein

1

14

High-throughput

0.541

High

1043380

ARF12
ADP-ribosylation factor 1-like 2

1

7

High-throughput

0.541

High

115297

H2KYX3
FERM domain-containing protein

2

18

High-throughput

0.526

High

1043382

Q17549
MAGUK p55 subfamily member 5

2

5

High-throughput

0.526

High

1043390

Q22554
TPR_REGION domain-containing protein

1

0

High-throughput

0.518

High

1043395

Q93156
BED-type domain-containing protein

1

9

High-throughput

0.508

High

196800

WASH1
WASH complex subunit homolog 1

1

4

High-throughput

0.494

High

1043389

Q22174
Tr-type G domain-containing protein

1

11

High-throughput

0.494

High

1043392

NU301
Nucleosome-remodeling factor subunit NURF301-like

1

20

High-throughput

0.494

High

92501

D3YT29
PDZ domain-containing protein

1

12

High-throughput

0.481

High

232032

HMP2
Beta-catenin-like protein hmp-2

1

12

High-throughput

0.481

High

264266

O62332
Importin N-terminal domain-containing protein

1

7

High-throughput

0.481

High

1043379

GARS
Glycine--tRNA ligase

1

2

High-throughput

0.481

High

1043399

Q9TXM1
Uncharacterized protein

1

3

High-throughput

0.479

High

90598

C1P633
Guanylate kinase

1

14

High-throughput

0.457

High

116249

H2L2I2
Armadillo/beta-catenin-like repeat protein

1

12

High-throughput

0.457

High

264288

O62333
Importin N-terminal domain-containing protein

1

5

High-throughput

0.457

High

1043393

Q8I711
Glycine--tRNA ligase

1

2

High-throughput

0.457

High

1043401

Q9U3S8
BED-type domain-containing protein

1

6

High-throughput

0.457

High

112813

G5EES2
Moesin/ezrin/radixin homolog 1

1

17

High-throughput

0.439

High

1043394

Q8ITW3
BZIP domain-containing protein

1

1

High-throughput

0.439

High

109689

G5EBK3
Moesin/ezrin/radixin homolog 1

1

17

High-throughput

0.417

High

115951

H2L0F6
BZIP domain-containing protein

1

1

High-throughput

0.417

High

109055

CDC26
Anaphase-promoting complex subunit CDC26

2

0

High-throughput

0.300

High

111093

G5ECR7
RNA polymerase II transcription factor SIII p18 subunit

2

0

High-throughput

0.300

High

759710

TPPC3
Trafficking protein particle complex subunit 3 homolog

2

0

High-throughput

0.300

High

234117

O45603
MEiosis-to-MItosis transition associated

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025