Protein: SIN1
Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)

Gene: SIN1, MAPKAP1
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q9BPZ7

Gene Ontology (top 5):
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787554

MTOR
Serine/threonine-protein kinase mTOR

22

5

Small-scale

0.989

High

1308716

LST8
Target of rapamycin complex subunit LST8

4

3

Small-scale

0.873

High

1163820

RICTR
Rapamycin-insensitive companion of mTOR

26

2

Small-scale

0.769

High

350488

RASK
GTPase KRas

2

1

High-throughput

0.754

High

903470

WDR5
WD repeat-containing protein 5

2

0

Small-scale

0.748

High

348890

RASN
GTPase NRas

1

1

High-throughput

0.747

High

682000

AKT1
RAC-alpha serine/threonine-protein kinase

5

5

Small-scale

0.721

High

905046

1433G
14-3-3 protein gamma

5

7

High-throughput

0.716

High

683668

1433B
14-3-3 protein beta/alpha

4

7

High-throughput

0.697

High

982433

1433F
14-3-3 protein eta

3

7

High-throughput

0.662

High

944396

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

Small-scale

0.646

High

927461

1433Z
14-3-3 protein zeta/delta

2

7

High-throughput

0.628

High

120607

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.618

High

564662

RHOQ
Rho-related GTP-binding protein RhoQ

1

2

High-throughput

0.618

High

921701

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.618

High

951271

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.618

High

1076728

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.618

High

1183522

RHOU
Rho-related GTP-binding protein RhoU

1

4

High-throughput

0.618

High

1296727

RHOV
Rho-related GTP-binding protein RhoV

1

4

High-throughput

0.618

High

1308721

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.618

High

1308723

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.618

High

1308735

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.618

High

1154441

PRR5L
Proline-rich protein 5-like

2

1

Small-scale

0.611

High

566470

KPCA
Protein kinase C alpha type

2

4

Small-scale

0.606

High

749821

BRCA1
Breast cancer type 1 susceptibility protein

2

0

Small-scale

0.593

High

800824

MK08
Mitogen-activated protein kinase 8

1

2

Small-scale

0.578

High

370303

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

952938

PRR5
Proline-rich protein 5

1

1

Small-scale

0.554

High

647226

1433T
14-3-3 protein theta

1

7

High-throughput

0.536

High

861911

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.536

High

909962

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.536

High

916800

RS6
Small ribosomal subunit protein eS6

1

1

Small-scale

0.536

High

1069644

STK38
Serine/threonine-protein kinase 38

1

4

Small-scale

0.536

High

437210

MDR1
ATP-dependent translocase ABCB1

1

0

High-throughput

0.518

High

960649

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.518

High

684295

1433S
14-3-3 protein sigma

1

7

High-throughput

0.515

High

969107

KPCE
Protein kinase C epsilon type

1

3

Small-scale

0.515

High

854207

JAK3
Tyrosine-protein kinase JAK3

1

0

High-throughput

0.513

High

1160965

CTR9
RNA polymerase-associated protein CTR9 homolog

1

0

High-throughput

0.513

High

1283574

TRI52
E3 ubiquitin-protein ligase TRIM52

1

0

High-throughput

0.513

High

1308717

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

0

High-throughput

0.513

High

1308722

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1308741

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

117028

SGK1
Serine/threonine-protein kinase Sgk1

1

5

Small-scale

0.501

High

476278

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

160741

AURKA
Aurora kinase A

1

4

Small-scale

0.479

High

166607

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.479

High

196498

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

216963

KIF1C
Kinesin-like protein KIF1C

1

1

High-throughput

0.479

High

230906

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

4

High-throughput

0.479

High

264385

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.479

High

584462

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.479

High

591397

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

Small-scale

0.479

High

598517

NF1
Neurofibromin

1

1

High-throughput

0.479

High

673517

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

673620

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

835104

TSC2
Tuberin

1

1

Small-scale

0.479

High

919494

RL23
Large ribosomal subunit protein uL14

1

1

Small-scale

0.479

High

960406

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

1042390

CUL3
Cullin-3

1

1

High-throughput

0.479

High

1043540

CUL4B
Cullin-4B

1

1

Small-scale

0.479

High

1082623

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.479

High

1085491

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.479

High

1136539

SPD2A
SH3 and PX domain-containing protein 2A

1

1

High-throughput

0.479

High

1139628

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.479

High

1167964

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.479

High

1253335

F110B
Protein FAM110B

1

1

High-throughput

0.479

High

1256248

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.479

High

1269461

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1292189

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1296878

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

1308713

F110A
Protein FAM110A

1

1

High-throughput

0.479

High

1308718

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

Small-scale

0.479

High

1308720

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

1308724

KI13B
Kinesin-like protein KIF13B

1

1

High-throughput

0.479

High

1308731

NGAP
Ras GTPase-activating protein nGAP

1

1

High-throughput

0.479

High

1308736

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.479

High

1308737

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

1

Small-scale

0.479

High

163194

XPO1
Exportin-1

1

0

High-throughput

0.458

High

237301

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

246271

NBN
Nibrin

1

0

Small-scale

0.458

High

253401

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

316273

NADK
NAD kinase

1

0

High-throughput

0.458

High

352233

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

547846

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

Small-scale

0.458

High

779991

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

793443

MUC18
Cell surface glycoprotein MUC18

1

0

Small-scale

0.458

High

819594

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.458

High

880811

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

997210

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.458

High

1022441

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.458

High

1025524

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

1057193

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.458

High

1060605

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1072169

PCBP2
Poly(rC)-binding protein 2

1

0

Small-scale

0.458

High

1101247

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1109685

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.458

High

1136476

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.458

High

1153352

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.458

High

1197828

PHLB2
Pleckstrin homology-like domain family B member 2

1

0

High-throughput

0.458

High

1217978

KSR1
Kinase suppressor of Ras 1

1

0

High-throughput

0.458

High

1243681

NAV1
Neuron navigator 1

1

0

High-throughput

0.458

High

1263453

SRS12
Serine/arginine-rich splicing factor 12

1

0

High-throughput

0.458

High

1267532

TSC1
Hamartin

1

0

Small-scale

0.458

High

1300434

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1300662

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

0

High-throughput

0.458

High

1301706

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

1308715

RTKN
Rhotekin

1

0

High-throughput

0.458

High

1308719

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1308725

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

1308727

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.458

High

1308728

CING
Cingulin

1

0

High-throughput

0.458

High

1308729

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1308730

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

1308732

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

1308733

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.458

High

1308734

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

1308738

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

1308740

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.458

High

883622

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

916338

RL23A
Large ribosomal subunit protein uL23

1

1

Small-scale

0.445

High

1173144

SYDE1
Rho GTPase-activating protein SYDE1

1

1

High-throughput

0.437

High

1256276

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

1

High-throughput

0.437

High

347720

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.426

High

806986

RS9
Small ribosomal subunit protein uS4

1

0

Small-scale

0.426

High

898726

RL26
Large ribosomal subunit protein uL24

1

0

Small-scale

0.426

High

1297403

CI072
Guanine nucleotide exchange factor C9orf72

1

0

Small-scale

0.426

High

785673

ECI1
Enoyl-CoA delta isomerase 1, mitochondrial

1

0

High-throughput

0.282

High

1101753

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1308739

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.279

Low

1149001

AN34A
Ankyrin repeat domain-containing protein 34A

1

0

High-throughput

0.249

Low

1308714

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

1308726

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024