Protein: AKT3
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)

Gene: AKT3
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9Y243

Gene Ontology (top 5):
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158609

CDC37
Hsp90 co-chaperone Cdc37

4

15

Small-scale

0.895

High

462058

HS90A
Heat shock protein HSP 90-alpha

3

20

High-throughput

0.861

High

468928

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.811

High

728491

AKT1
RAC-alpha serine/threonine-protein kinase

2

17

High-throughput

0.811

High

1106135

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

12

High-throughput

0.811

High

1490485

SNX8
Sorting nexin-8

2

6

High-throughput

0.811

High

891895

GSK3B
Glycogen synthase kinase-3 beta

2

20

Small-scale

0.778

High

1051338

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.756

High

1202016

H90B4
Putative heat shock protein HSP 90-beta 4

2

20

High-throughput

0.712

High

1202034

H90B3
Putative heat shock protein HSP 90-beta-3

2

20

High-throughput

0.712

High

1202085

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

1202133

HS904
Putative heat shock protein HSP 90-alpha A4

2

20

High-throughput

0.712

High

51128

PKHG3
Pleckstrin homology domain-containing family G member 3

1

8

High-throughput

0.691

High

270413

WDR1
WD repeat-containing protein 1

1

7

High-throughput

0.691

High

666780

MYL9
Myosin regulatory light polypeptide 9

1

3

High-throughput

0.691

High

728630

AKT2
RAC-beta serine/threonine-protein kinase

1

17

High-throughput

0.691

High

922086

COPA
Coatomer subunit alpha

1

5

High-throughput

0.691

High

1153235

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

20

High-throughput

0.691

High

1327359

AFAP1
Actin filament-associated protein 1

1

3

High-throughput

0.691

High

1406247

CHP1
Calcineurin B homologous protein 1

1

0

High-throughput

0.656

High

1396943

ANM6
Protein arginine N-methyltransferase 6

2

2

High-throughput

0.628

High

1399149

TOX2
TOX high mobility group box family member 2

2

6

High-throughput

0.628

High

994423

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

11

Small-scale

0.619

High

247467

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

19

Small-scale

0.618

High

573725

ENPL
Endoplasmin

1

20

High-throughput

0.618

High

629178

CCNA2
Cyclin-A2

1

3

Small-scale

0.618

High

1245587

Q6PK50
HSP90AB1 protein

1

20

High-throughput

0.618

High

1256839

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

15

Small-scale

0.618

High

1461087

DP13A
DCC-interacting protein 13-alpha

1

7

Small-scale

0.618

High

1315177

PIANP
PILR alpha-associated neural protein

2

0

High-throughput

0.602

High

1199161

PKHO1
Pleckstrin homology domain-containing family O member 1

1

2

Small-scale

0.595

High

1402998

IWS1
Protein IWS1 homolog

1

2

Small-scale

0.561

High

861844

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

High-throughput

0.536

High

228004

MYO1B
Unconventional myosin-Ib

1

9

High-throughput

0.536

High

424473

HMGN1
Non-histone chromosomal protein HMG-14

1

2

High-throughput

0.536

High

442532

GELS
Gelsolin

1

1

High-throughput

0.536

High

591397

CD44
CD44 antigen

1

2

High-throughput

0.536

High

637795

FLNA
Filamin-A

1

1

High-throughput

0.536

High

715850

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.536

High

754605

S10A3
Protein S100-A3

1

12

High-throughput

0.536

High

857203

NSF
Vesicle-fusing ATPase

1

6

High-throughput

0.536

High

867526

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

908479

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.536

High

961895

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.536

High

989172

AP2B1
AP-2 complex subunit beta

1

5

High-throughput

0.536

High

1010397

BASP1
Brain acid soluble protein 1

1

3

High-throughput

0.536

High

1022205

DAB2
Disabled homolog 2

1

6

High-throughput

0.536

High

1052126

CALD1
Caldesmon

1

19

High-throughput

0.536

High

1103602

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

8

High-throughput

0.536

High

1124949

FLOT2
Flotillin-2

1

3

High-throughput

0.536

High

1127803

K1H2
Keratin, type I cuticular Ha2

1

8

High-throughput

0.536

High

1273874

MICA3
[F-actin]-monooxygenase MICAL3

1

4

High-throughput

0.536

High

923650

TTC3
E3 ubiquitin-protein ligase TTC3

1

7

Small-scale

0.534

High

940475

TCL1A
T-cell leukemia/lymphoma protein 1A

1

7

Small-scale

0.515

High

271191

COBL
Protein cordon-bleu

1

0

High-throughput

0.513

High

1335498

SEN2
tRNA-splicing endonuclease subunit Sen2

1

0

High-throughput

0.513

High

1490486

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

384586

CRYAA
Alpha-crystallin A chain

1

10

High-throughput

0.501

High

1400053

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

High-throughput

0.501

High

1490484

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

384214

CO1A1
Collagen alpha-1(I) chain

1

2

High-throughput

0.489

High

1250075

ABH15
Protein ABHD15

1

1

High-throughput

0.489

High

1398866

DOCK7
Dedicator of cytokinesis protein 7

1

3

High-throughput

0.489

High

840097

CASP3
Caspase-3

1

4

Small-scale

0.484

High

482984

TPM1
Tropomyosin alpha-1 chain

1

7

High-throughput

0.479

High

995509

TPM4
Tropomyosin alpha-4 chain

1

7

High-throughput

0.479

High

1032565

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

2

Small-scale

0.479

High

1112802

CUL1
Cullin-1

1

5

Small-scale

0.479

High

723273

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

0

High-throughput

0.458

High

1401908

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.458

High

104396

F5H7S3
Tropomyosin 1

1

7

High-throughput

0.445

High

1218370

OTUD1
OTU domain-containing protein 1

1

4

Small-scale

0.437

High

1386846

KCD12
BTB/POZ domain-containing protein KCTD12

1

3

Small-scale

0.437

High

117302

K7ENT6
Tropomyosin 4

1

7

High-throughput

0.407

High

635810

PTMS
Parathymosin

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025