Protein: PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)

Gene: PLCG2
Organism: Homo sapiens
Interactions: 82
UniProt ID: P16885

Gene Ontology (top 5):
GO:0001775 - cell activation
GO:0001784 - phosphotyrosine residue binding
GO:0001878 - response to yeast
GO:0002092 - positive regulation of receptor internalization
GO:0002223 - stimulatory C-type lectin receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337886

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.928

High

433564

LYN
Tyrosine-protein kinase Lyn

3

17

Small-scale

0.882

High

383591

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

386047

P53
Cellular tumor antigen p53

2

4

High-throughput

0.767

High

562629

SHC1
SHC-transforming protein 1

2

13

Small-scale

0.754

High

562633

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.754

High

562642

BTK
Tyrosine-protein kinase BTK

2

16

Small-scale

0.754

High

562661

ASB9
Ankyrin repeat and SOCS box protein 9

2

1

High-throughput

0.743

High

562628

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

6

Small-scale

0.724

High

155831

SH21B
SH2 domain-containing protein 1B

1

20

Small-scale

0.710

High

441423

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

499228

KIT
Mast/stem cell growth factor receptor Kit

1

18

High-throughput

0.692

High

562645

GAB1
GRB2-associated-binding protein 1

1

4

High-throughput

0.692

High

562659

BLNK
B-cell linker protein

1

6

Small-scale

0.691

High

562663

EPYC
Epiphycan

2

1

High-throughput

0.686

High

562658

GABP2
GA-binding protein subunit beta-2

2

1

High-throughput

0.665

High

411992

FYN
Tyrosine-protein kinase Fyn

1

17

Small-scale

0.647

High

562623

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

19

High-throughput

0.647

High

562634

BLK
Tyrosine-protein kinase Blk

1

17

Small-scale

0.647

High

562648

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

17

High-throughput

0.647

High

562650

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.646

High

207421

LAT
Linker for activation of T-cells family member 1

2

2

Small-scale

0.629

High

226448

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.618

High

238350

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

507835

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.618

High

548630

VAV
Proto-oncogene vav

1

6

Small-scale

0.618

High

562619

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

5

Small-scale

0.618

High

562620

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.618

High

562625

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

562627

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.618

High

562638

GRB2
Growth factor receptor-bound protein 2

1

17

High-throughput

0.618

High

562641

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

5

Small-scale

0.618

High

562644

PLD1
Phospholipase D1

1

2

Small-scale

0.618

High

562647

KPCD1
Serine/threonine-protein kinase D1

1

5

Small-scale

0.618

High

562667

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.618

High

562669

GAB2
GRB2-associated-binding protein 2

1

5

Small-scale

0.618

High

198536

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

0

High-throughput

0.601

High

562621

EPOR
Erythropoietin receptor

1

7

Small-scale

0.590

High

562635

EPHA4
Ephrin type-A receptor 4

1

11

High-throughput

0.590

High

496239

TAU
Microtubule-associated protein tau

2

6

Small-scale

0.584

High

562636

ISL1
Insulin gene enhancer protein ISL-1

2

1

High-throughput

0.576

High

562649

RBP1
RalA-binding protein 1

2

4

High-throughput

0.576

High

562660

TWST2
Twist-related protein 2

2

2

High-throughput

0.576

High

562639

3BP2
SH3 domain-binding protein 2

1

1

Small-scale

0.575

High

330175

PTTG1
Securin

2

0

High-throughput

0.569

High

499514

CH60
60 kDa heat shock protein, mitochondrial

2

0

High-throughput

0.569

High

562670

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.553

High

499383

ESTD
S-formylglutathione hydrolase

2

0

High-throughput

0.551

High

562656

KCD17
BTB/POZ domain-containing protein KCTD17

2

0

High-throughput

0.551

High

562653

LHX8
LIM/homeobox protein Lhx8

2

1

High-throughput

0.542

High

487107

ANDR
Androgen receptor

1

4

High-throughput

0.536

High

562624

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.536

High

562631

IRS1
Insulin receptor substrate 1

1

4

Small-scale

0.527

High

562671

RA54B
DNA repair and recombination protein RAD54B

1

3

High-throughput

0.504

High

562664

CD244
Natural killer cell receptor 2B4

1

6

Small-scale

0.501

High

548188

CD19
B-lymphocyte antigen CD19

1

0

Small-scale

0.480

High

195966

PLXB1
Plexin-B1

1

6

Small-scale

0.479

High

308388

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

345853

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

562643

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.479

High

562646

SRC8
Src substrate cortactin

1

3

Small-scale

0.479

High

562652

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

562665

NTAL
Linker for activation of T-cells family member 2

1

1

Small-scale

0.479

High

562662

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.464

High

117344

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

299314

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

562630

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

Small-scale

0.458

High

562637

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

562654

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

0

Small-scale

0.458

High

233737

NDK8
Putative nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

562651

HS904
Putative heat shock protein HSP 90-alpha A4

1

1

High-throughput

0.445

High

551891

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

562626

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

562632

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.437

High

562622

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.310

High

562655

BOP
Protein Bop

2

0

High-throughput

0.300

High

562657

SETD9
SET domain-containing protein 9

2

0

High-throughput

0.300

High

562668

ZKSC7
Zinc finger protein with KRAB and SCAN domains 7

2

0

High-throughput

0.300

High

562640

S35A2
UDP-galactose translocator

1

0

High-throughput

0.279

Low

304465

FSBP
Fibrinogen silencer-binding protein

1

0

High-throughput

0.264

Low

562666

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024