Protein: OPA1
Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)]

Gene: OPA1
Organism: Homo sapiens
Interactions: 173
UniProt ID: O60313

Gene Ontology (top 5):
GO:0000002 - mitochondrial genome maintenance
GO:0000266 - mitochondrial fission
GO:0000287 - magnesium ion binding
GO:0001843 - neural tube closure
GO:0003924 - GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

231064

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

3

4

High-throughput

0.667

High

225987

PRKN
E3 ubiquitin-protein ligase parkin

3

9

High-throughput

0.640

High

231032

SEGN
Secretagogin

3

0

High-throughput

0.638

High

231051

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

0

High-throughput

0.613

High

231039

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.611

High

231096

CUL3
Cullin-3

2

1

High-throughput

0.611

High

231025

SCN2B
Sodium channel subunit beta-2

3

3

High-throughput

0.609

High

231042

A4
Amyloid-beta precursor protein

2

3

High-throughput

0.602

High

231129

F174A
Membrane protein FAM174A

2

0

High-throughput

0.602

High

231171

GID8
Glucose-induced degradation protein 8 homolog

2

0

High-throughput

0.602

High

231106

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

9

Small-scale

0.588

High

231036

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

1

High-throughput

0.584

High

231049

HSP7C
Heat shock cognate 71 kDa protein

2

3

High-throughput

0.584

High

231085

RHOB
Rho-related GTP-binding protein RhoB

2

3

High-throughput

0.584

High

231118

MAVS
Mitochondrial antiviral-signaling protein

2

3

Small-scale

0.584

High

231134

AKAP1
A-kinase anchor protein 1, mitochondrial

2

3

High-throughput

0.584

High

231155

CLPB
Mitochondrial disaggregase

2

3

Small-scale

0.584

High

231162

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

231070

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

1

High-throughput

0.574

High

231092

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

0

Small-scale

0.569

High

231167

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

5

Small-scale

0.561

High

231147

YMEL1
ATP-dependent zinc metalloprotease YME1L1

2

0

High-throughput

0.559

High

200075

DAPK3
Death-associated protein kinase 3

1

1

High-throughput

0.536

High

231043

S10A6
Protein S100-A6

1

2

High-throughput

0.536

High

231058

EPHA1
Ephrin type-A receptor 1

1

4

High-throughput

0.536

High

231066

PTN7
Tyrosine-protein phosphatase non-receptor type 7

1

2

High-throughput

0.536

High

231072

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.536

High

231080

TPTE
Putative tyrosine-protein phosphatase TPTE

1

2

High-throughput

0.536

High

231090

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

1

High-throughput

0.536

High

231119

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

231149

CML1
Chemerin-like receptor 1

1

4

High-throughput

0.536

High

231183

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

231163

PLRKT
Plasminogen receptor

2

1

High-throughput

0.533

High

231088

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.515

High

231103

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.515

High

169328

BET1
BET1 homolog

1

0

High-throughput

0.513

High

206984

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

231046

NEP
Neprilysin

1

0

Small-scale

0.513

High

231124

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.513

High

231137

KAT2B
Histone acetyltransferase KAT2B

1

4

Small-scale

0.501

High

231044

NPM
Nucleophosmin

1

0

High-throughput

0.493

High

231060

PIT1
Pituitary-specific positive transcription factor 1

1

0

High-throughput

0.493

High

126563

P2Y10
Putative P2Y purinoceptor 10

1

4

High-throughput

0.489

High

231062

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

231075

NPY2R
Neuropeptide Y receptor type 2

1

2

High-throughput

0.489

High

231094

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

3

High-throughput

0.489

High

231185

GPR45
Probable G-protein coupled receptor 45

1

6

High-throughput

0.489

High

231186

NPTN
Neuroplastin

1

3

High-throughput

0.489

High

118130

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.479

High

154896

NDC80
Kinetochore protein NDC80 homolog

1

3

High-throughput

0.479

High

180767

YKT6
Synaptobrevin homolog YKT6

1

2

High-throughput

0.479

High

203830

HTRA2
Serine protease HTRA2, mitochondrial

1

1

High-throughput

0.479

High

231028

TP4A3
Protein tyrosine phosphatase type IVA 3

1

3

High-throughput

0.479

High

231029

MTX2
Metaxin-2

1

2

High-throughput

0.479

High

231030

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

231033

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

231034

TOM70
Mitochondrial import receptor subunit TOM70

1

4

High-throughput

0.479

High

231035

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

231037

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

2

High-throughput

0.479

High

231038

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

231041

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

231045

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.479

High

231047

TPM1
Tropomyosin alpha-1 chain

1

4

High-throughput

0.479

High

231050

KCRU
Creatine kinase U-type, mitochondrial

1

4

High-throughput

0.479

High

231053

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

231054

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.479

High

231057

LMNB1
Lamin-B1

1

2

High-throughput

0.479

High

231059

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

231063

PML
Protein PML

1

2

High-throughput

0.479

High

231065

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

231067

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

231068

MYH10
Myosin-10

1

2

High-throughput

0.479

High

231069

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

231071

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

6

High-throughput

0.479

High

231073

KC1A
Casein kinase I isoform alpha

1

1

High-throughput

0.479

High

231074

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

231076

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

231077

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.479

High

231081

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

231083

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

231084

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.479

High

231086

TPM4
Tropomyosin alpha-4 chain

1

4

High-throughput

0.479

High

231089

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

231091

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

231095

MTX1
Metaxin-1

1

2

High-throughput

0.479

High

231097

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.479

High

231098

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

5

High-throughput

0.479

High

231100

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

231101

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

231104

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.479

High

231105

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

231112

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

1

High-throughput

0.479

High

231114

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

231115

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

1

High-throughput

0.479

High

231120

LRC49
Leucine-rich repeat-containing protein 49

1

4

High-throughput

0.479

High

231121

MICU2
Calcium uptake protein 2, mitochondrial

1

1

High-throughput

0.479

High

231131

PHIP
PH-interacting protein

1

3

High-throughput

0.479

High

231133

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

231136

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

231139

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

Small-scale

0.479

High

231141

OPTN
Optineurin

1

10

High-throughput

0.479

High

231143

MYO19
Unconventional myosin-XIX

1

3

High-throughput

0.479

High

231144

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

231145

RUFY1
RUN and FYVE domain-containing protein 1

1

3

High-throughput

0.479

High

231146

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

231148

PHB2
Prohibitin-2

1

2

High-throughput

0.479

High

231150

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.479

High

231154

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.479

High

231156

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

231157

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

High-throughput

0.479

High

231159

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

231161

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

231168

DJC11
DnaJ homolog subfamily C member 11

1

4

High-throughput

0.479

High

231169

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

High-throughput

0.479

High

231170

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.479

High

231172

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

231173

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

Small-scale

0.479

High

231174

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.479

High

231176

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

231177

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

2

High-throughput

0.479

High

231178

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

231179

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.479

High

231180

TDRKH
Tudor and KH domain-containing protein

1

2

High-throughput

0.479

High

231182

SAM50
Sorting and assembly machinery component 50 homolog

1

2

High-throughput

0.479

High

231184

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.479

High

120115

TLR4
Toll-like receptor 4

1

0

Small-scale

0.458

High

182474

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

231026

CLU
Clustered mitochondria protein homolog

1

0

High-throughput

0.458

High

231027

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

231031

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

231052

CX6B1
Cytochrome c oxidase subunit 6B1

1

0

High-throughput

0.458

High

231055

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

231056

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

231078

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

231079

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

231087

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

231093

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

231099

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

231116

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

231122

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

231123

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

231125

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

231126

MIGA1
Mitoguardin 1

1

0

High-throughput

0.458

High

231127

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

231128

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.458

High

231142

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

231151

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

231152

DERL1
Derlin-1

1

0

High-throughput

0.458

High

231153

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

231160

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.458

High

231164

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

231166

DUS22
Dual specificity protein phosphatase 22

1

0

High-throughput

0.458

High

231175

CISD1
CDGSH iron-sulfur domain-containing protein 1

1

0

High-throughput

0.458

High

231082

STXB1
Syntaxin-binding protein 1

1

1

High-throughput

0.457

High

231165

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

231048

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.445

High

231061

GRN
Progranulin

1

1

High-throughput

0.445

High

231102

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

2

High-throughput

0.445

High

231110

Q6NSK7
RIN3 protein

1

0

High-throughput

0.438

High

231140

CHP3
Calcineurin B homologous protein 3

1

0

High-throughput

0.438

High

231117

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

231132

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

231108

ZN776
Zinc finger protein 776

1

0

High-throughput

0.279

Low

231113

INSY2
Inhibitory synaptic factor 2A

1

0

High-throughput

0.279

Low

231138

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

231130

ENKUR
Enkurin

1

0

High-throughput

0.269

Low

231040

GBA1
Lysosomal acid glucosylceramidase

1

0

Small-scale

0.249

Low

231107

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

231109

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

231111

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

231135

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

0

High-throughput

0.249

Low

231158

TRABD
TraB domain-containing protein

1

0

High-throughput

0.249

Low

231181

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024