Protein: PTN22
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)

Gene: PTN22, PTPN22
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q9Y2R2

Gene Ontology (top 5):
GO:0002230 - positive regulation of defense response to virus by host
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

411900

LCK
Tyrosine-protein kinase Lck

3

20

Small-scale

0.882

High

339171

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.867

High

1377360

PTN22
Tyrosine-protein phosphatase non-receptor type 22

3

17

Small-scale

0.834

High

796490

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

Small-scale

0.777

High

782837

CSK
Tyrosine-protein kinase CSK

2

20

High-throughput

0.754

High

924971

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.747

High

548767

VAV
Proto-oncogene vav

1

19

Small-scale

0.691

High

207851

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

14

Small-scale

0.652

High

384039

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

385757

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.647

High

452498

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.647

High

523222

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.647

High

802787

CRK
Adapter molecule crk

1

20

High-throughput

0.647

High

1333999

PPIP2
Proline-serine-threonine phosphatase-interacting protein 2

2

12

High-throughput

0.601

High

269544

SKAP2
Src kinase-associated phosphoprotein 2

1

20

Small-scale

0.598

High

596601

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

2

Small-scale

0.586

High

430730

CD3E
T-cell surface glycoprotein CD3 epsilon chain

1

1

Small-scale

0.536

High

875454

TERA
Transitional endoplasmic reticulum ATPase

1

6

Small-scale

0.536

High

443893

VIME
Vimentin

1

2

High-throughput

0.515

High

610538

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.515

High

679414

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

2

High-throughput

0.515

High

182226

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

8

High-throughput

0.501

High

500978

GHR
Growth hormone receptor

1

20

High-throughput

0.501

High

580269

CADH2
Cadherin-2

1

20

High-throughput

0.501

High

790695

WASP
Actin nucleation-promoting factor WAS

1

11

High-throughput

0.501

High

833841

CLK1
Dual specificity protein kinase CLK1

1

2

High-throughput

0.501

High

943028

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.501

High

984552

KPCD
Protein kinase C delta type

1

2

Small-scale

0.501

High

1078935

ITSN1
Intersectin-1

1

8

High-throughput

0.501

High

426922

CRGD
Gamma-crystallin D

1

0

High-throughput

0.493

High

360672

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.479

High

388814

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.479

High

533888

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

2

High-throughput

0.479

High

653771

CALR
Calreticulin

1

11

High-throughput

0.479

High

933076

ACTS
Actin, alpha skeletal muscle

1

5

Small-scale

0.479

High

1024790

TRAF3
TNF receptor-associated factor 3

1

9

Small-scale

0.479

High

1062977

MD2BP
MAD2L1-binding protein

1

1

High-throughput

0.479

High

1101563

KIF7
Kinesin-like protein KIF7

1

2

High-throughput

0.479

High

1203685

AROS
Active regulator of SIRT1

1

1

High-throughput

0.479

High

1206093

MIB1
E3 ubiquitin-protein ligase MIB1

1

5

High-throughput

0.479

High

1244010

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1288475

TBC31
TBC1 domain family member 31

1

1

High-throughput

0.479

High

1310233

LZTS2
Leucine zipper putative tumor suppressor 2

1

6

High-throughput

0.479

High

1310270

CAB45
45 kDa calcium-binding protein

1

6

High-throughput

0.479

High

1357675

CP131
Centrosomal protein of 131 kDa

1

1

High-throughput

0.479

High

204525

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.458

High

335218

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

831822

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

888465

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

1087752

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.458

High

1100956

MOONR
Protein moonraker

1

0

High-throughput

0.458

High

1264142

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.458

High

1335676

TPC
Mitochondrial thiamine pyrophosphate carrier

1

0

High-throughput

0.458

High

1342957

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

1356591

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1377192

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

118498

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.437

High

216364

CALU
Calumenin

1

6

High-throughput

0.437

High

1070958

RCN1
Reticulocalbin-1

1

6

High-throughput

0.437

High

1262406

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

2

High-throughput

0.437

High

215499

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

330371

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.249

Low

1159668

SFXN4
Sideroflexin-4

1

0

High-throughput

0.249

Low

1297658

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024