Protein: PPAL
Lysosomal acid phosphatase (LAP) (EC 3.1.3.2)

Gene: PPAL, ACP2
Organism: Homo sapiens
Interactions: 74
UniProt ID: P11117

Gene Ontology (top 5):
GO:0003993 - acid phosphatase activity
GO:0005764 - lysosome
GO:0005765 - lysosomal membrane
GO:0007040 - lysosome organization
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

121091

LEG8
Galectin-8

3

3

High-throughput

0.667

High

503199

LEG3
Galectin-3

2

3

High-throughput

0.611

High

503242

P2Y12
P2Y purinoceptor 12

2

1

High-throughput

0.611

High

503211

EREP3
Protein ENTREP3

2

0

High-throughput

0.585

High

503228

TM192
Transmembrane protein 192

2

0

High-throughput

0.585

High

503251

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.585

High

503201

S1PR1
Sphingosine 1-phosphate receptor 1

2

5

High-throughput

0.574

High

503227

STX12
Syntaxin-12

2

1

High-throughput

0.558

High

503235

LPAR1
Lysophosphatidic acid receptor 1

2

4

High-throughput

0.558

High

503248

FBX6
F-box only protein 6

2

3

High-throughput

0.558

High

178373

STX7
Syntaxin-7

1

1

High-throughput

0.536

High

179305

COPT2
Protein SLC31A2

1

1

High-throughput

0.536

High

449161

LEG1
Galectin-1

1

3

High-throughput

0.536

High

503204

CALX
Calnexin

1

5

High-throughput

0.536

High

503241

LMA2L
VIP36-like protein

1

1

High-throughput

0.536

High

118944

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

175599

VA0E1
V-type proton ATPase subunit e 1

1

0

High-throughput

0.513

High

254148

FZD7
Frizzled-7

1

0

High-throughput

0.513

High

503198

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.513

High

503206

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.513

High

503208

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

503210

1433G
14-3-3 protein gamma

1

0

High-throughput

0.513

High

503213

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.513

High

503219

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.513

High

503220

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

0

High-throughput

0.513

High

503222

S39A5
Zinc transporter ZIP5

1

0

High-throughput

0.513

High

503224

TS1R3
Taste receptor type 1 member 3

1

0

High-throughput

0.513

High

503229

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.513

High

503230

TPC2
Two pore channel protein 2

1

0

High-throughput

0.513

High

503231

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

503237

PMEPA
Protein TMEPAI

1

0

High-throughput

0.513

High

503239

T4S18
Transmembrane 4 L6 family member 18

1

0

High-throughput

0.513

High

503240

TMM74
Transmembrane protein 74

1

0

High-throughput

0.513

High

503250

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.513

High

503254

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

0

High-throughput

0.513

High

503216

PLEC
Plectin

1

0

High-throughput

0.493

High

119113

LEG9
Galectin-9

1

3

High-throughput

0.489

High

179140

COPT1
High affinity copper uptake protein 1

1

1

High-throughput

0.489

High

197120

SIA8C
Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3

1

1

High-throughput

0.489

High

304712

S1PR2
Sphingosine 1-phosphate receptor 2

1

4

High-throughput

0.489

High

328304

S1PR4
Sphingosine 1-phosphate receptor 4

1

5

High-throughput

0.489

High

503202

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

1

High-throughput

0.489

High

503232

GP151
G-protein coupled receptor 151

1

1

High-throughput

0.489

High

503238

RN166
E3 ubiquitin-protein ligase RNF166

1

1

High-throughput

0.489

High

503246

LPAR2
Lysophosphatidic acid receptor 2

1

5

High-throughput

0.489

High

503247

C1QR1
Complement component C1q receptor

1

1

High-throughput

0.489

High

503249

GP173
Probable G-protein coupled receptor 173

1

2

High-throughput

0.489

High

503252

FBX2
F-box only protein 2

1

3

High-throughput

0.489

High

503255

RN114
E3 ubiquitin-protein ligase RNF114

1

1

High-throughput

0.489

High

167819

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

475280

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

503209

GPR85
Probable G-protein coupled receptor 85

1

2

High-throughput

0.470

High

503236

KLK6
Kallikrein-6

1

3

High-throughput

0.470

High

503203

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.458

High

503223

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

503207

TRFR
Thyrotropin-releasing hormone receptor

3

0

High-throughput

0.345

High

352460

TNFA
Tumor necrosis factor

2

0

High-throughput

0.318

High

503217

SGCA
Alpha-sarcoglycan

2

0

High-throughput

0.318

High

327131

CF047
Uncharacterized protein C6orf47

1

0

High-throughput

0.279

Low

503200

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.279

Low

503205

5HT2C
5-hydroxytryptamine receptor 2C

1

0

High-throughput

0.279

Low

503215

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

503218

ZFY27
Protrudin

1

0

High-throughput

0.279

Low

503221

BTNL3
Butyrophilin-like protein 3

1

0

High-throughput

0.279

Low

503225

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.279

Low

503233

RN133
E3 ubiquitin-protein ligase RNF133

1

0

High-throughput

0.279

Low

503234

SGCD
Delta-sarcoglycan

1

0

High-throughput

0.279

Low

503243

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.279

Low

503244

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

503245

IPPK
Inositol-pentakisphosphate 2-kinase

1

0

High-throughput

0.279

Low

503214

PAK1
Serine/threonine-protein kinase PAK 1

1

0

High-throughput

0.268

Low

503226

Q86V38
Atrophin 1

1

0

High-throughput

0.268

Low

503253

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.268

Low

503212

CBX1
Chromobox protein homolog 1

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024