Protein: ACLY
ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)

Gene: ACLY
Organism: Homo sapiens
Interactions: 216
UniProt ID: P53396

Gene Ontology (top 5):
GO:0003878 - ATP citrate synthase activity
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

862360

ACLY
ATP-citrate synthase

4

7

Small-scale

0.868

High

862386

CUL3
Cullin-3

3

5

Small-scale

0.674

High

475512

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

6

Small-scale

0.646

High

226945

PRKN
E3 ubiquitin-protein ligase parkin

3

7

High-throughput

0.640

High

346306

MYC
Myc proto-oncogene protein

3

4

High-throughput

0.640

High

666046

SHC1
SHC-transforming protein 1

3

2

High-throughput

0.633

High

862471

KLH25
Kelch-like protein 25

2

0

Small-scale

0.607

High

397861

ISG15
Ubiquitin-like protein ISG15

2

6

High-throughput

0.601

High

528816

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.601

High

835600

GSK3B
Glycogen synthase kinase-3 beta

2

1

High-throughput

0.601

High

373924

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

5

High-throughput

0.584

High

779076

CCNF
Cyclin-F

2

2

High-throughput

0.584

High

862380

EP300
Histone acetyltransferase p300

2

1

High-throughput

0.584

High

862451

FBXW7
F-box/WD repeat-containing protein 7

2

3

Small-scale

0.584

High

607614

NDKB
Nucleoside diphosphate kinase B

2

0

Small-scale

0.576

High

862396

KPCD1
Serine/threonine-protein kinase D1

2

2

High-throughput

0.571

High

862404

PKHG6
Pleckstrin homology domain-containing family G member 6

2

3

High-throughput

0.571

High

322369

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

862361

ATX3
Ataxin-3

2

0

Small-scale

0.559

High

862410

UBR4
E3 ubiquitin-protein ligase UBR4

2

0

Small-scale

0.559

High

862466

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

672046

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

High-throughput

0.554

High

862372

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.554

High

862375

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.554

High

862412

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

3

High-throughput

0.554

High

862494

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

1

3

High-throughput

0.554

High

362963

FINC
Fibronectin

1

1

High-throughput

0.536

High

496622

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.536

High

791406

HD
Huntingtin

1

3

High-throughput

0.536

High

848332

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

862379

KPCZ
Protein kinase C zeta type

1

2

High-throughput

0.536

High

862385

CUL2
Cullin-2

1

5

High-throughput

0.536

High

862398

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

862402

AAK1
AP2-associated protein kinase 1

1

1

High-throughput

0.536

High

862427

PIM3
Serine/threonine-protein kinase pim-3

1

2

High-throughput

0.536

High

862430

MYLK4
Myosin light chain kinase family member 4

1

3

High-throughput

0.536

High

862441

MK15
Mitogen-activated protein kinase 15

1

1

High-throughput

0.536

High

862442

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

862452

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.536

High

862465

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

862478

PAK6
Serine/threonine-protein kinase PAK 6

1

4

High-throughput

0.536

High

862491

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.536

High

862500

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.536

High

843583

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

790717

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

3

Small-scale

0.516

High

585638

TFE3
Transcription factor E3

1

2

High-throughput

0.515

High

128501

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

176416

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

579326

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

0

High-throughput

0.513

High

861672

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

862365

NU107
Nuclear pore complex protein Nup107

1

0

High-throughput

0.513

High

862374

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

862421

HAKAI
E3 ubiquitin-protein ligase Hakai

1

0

Small-scale

0.513

High

862428

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

862450

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

809882

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

High-throughput

0.493

High

862388

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.493

High

862497

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.493

High

862499

TNPO3
Transportin-3

1

1

High-throughput

0.489

High

159932

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

394385

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

129724

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

2

High-throughput

0.479

High

200867

CTIF
CBP80/20-dependent translation initiation factor

1

1

Small-scale

0.479

High

214160

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

232823

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

5

High-throughput

0.479

High

244161

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

255615

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.479

High

275557

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

2

High-throughput

0.479

High

294570

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

314272

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

Small-scale

0.479

High

379159

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

384547

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

386365

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

393115

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

High-throughput

0.479

High

428106

TBB5
Tubulin beta chain

1

1

Small-scale

0.479

High

487259

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

503740

HSP7C
Heat shock cognate 71 kDa protein

1

4

Small-scale

0.479

High

538166

ENPL
Endoplasmin

1

3

High-throughput

0.479

High

552311

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

569446

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

650754

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

682744

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

Small-scale

0.479

High

684550

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

708849

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.479

High

716902

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

720046

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

742153

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

808416

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

823743

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

862362

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

862363

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

862366

IF4A1
Eukaryotic initiation factor 4A-I

1

2

Small-scale

0.479

High

862368

MAX
Protein max

1

4

High-throughput

0.479

High

862369

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.479

High

862370

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

862371

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

862382

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

862383

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

862384

TBB3
Tubulin beta-3 chain

1

1

Small-scale

0.479

High

862390

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

Small-scale

0.479

High

862391

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

862394

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

862395

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

862397

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

862399

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

862405

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

862406

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

862415

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

862418

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

3

High-throughput

0.479

High

862420

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

862423

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

862424

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

862425

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

Small-scale

0.479

High

862429

GOLI
E3 ubiquitin-protein ligase RNF130

1

3

High-throughput

0.479

High

862432

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

4

Small-scale

0.479

High

862437

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

Small-scale

0.479

High

862446

REQU
Zinc finger protein ubi-d4

1

2

High-throughput

0.479

High

862447

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.479

High

862448

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

Small-scale

0.479

High

862449

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

Small-scale

0.479

High

862453

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

862454

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

862455

OPTN
Optineurin

1

1

High-throughput

0.479

High

862460

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

862461

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

862462

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

862464

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

862469

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

Small-scale

0.479

High

862472

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

Small-scale

0.479

High

862474

Q9H4D1
Protein kinase

1

2

High-throughput

0.479

High

862476

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

862480

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

862481

HELLS
Lymphoid-specific helicase

1

2

Small-scale

0.479

High

862484

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

862488

HDAC6
Histone deacetylase 6

1

2

High-throughput

0.479

High

862489

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

862492

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.479

High

862493

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

862498

TRAF6
TNF receptor-associated factor 6

1

2

Small-scale

0.479

High

119272

LEG9
Galectin-9

1

0

High-throughput

0.458

High

862392

CUL7
Cullin-7

1

0

High-throughput

0.458

High

862393

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

164837

SC16A
Protein transport protein Sec16A

1

0

Small-scale

0.458

High

205205

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

233302

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

298309

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

303040

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

326527

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

329530

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

373004

VTNC
Vitronectin

1

0

High-throughput

0.458

High

616195

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

724190

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

749271

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

771850

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

842296

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

862367

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

862373

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

862376

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

862378

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

862381

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

862389

TFDP2
Transcription factor Dp-2

1

0

High-throughput

0.458

High

862401

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

862411

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

862413

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

862416

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

862426

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

862431

DYH10
Dynein axonemal heavy chain 10

1

0

High-throughput

0.458

High

862433

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.458

High

862438

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

862440

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

862443

ASB15
Ankyrin repeat and SOCS box protein 15

1

0

High-throughput

0.458

High

862444

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

862458

CIC
Protein capicua homolog

1

0

Small-scale

0.458

High

862463

DERL1
Derlin-1

1

0

Small-scale

0.458

High

862468

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

862470

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

862473

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

862477

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

862479

ANLN
Anillin

1

0

High-throughput

0.458

High

862483

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

862485

PD1L1
Programmed cell death 1 ligand 1

1

0

Small-scale

0.458

High

862486

ATX10
Ataxin-10

1

0

High-throughput

0.458

High

862496

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

439069

ELNE
Neutrophil elastase

1

3

Small-scale

0.457

High

330923

PAK4
Serine/threonine-protein kinase PAK 4

1

4

High-throughput

0.445

High

401684

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

414471

PRGR
Progesterone receptor

1

2

Small-scale

0.445

High

862364

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

862409

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

862414

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

862445

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

862387

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.437

High

862400

CRY1
Cryptochrome-1

1

1

High-throughput

0.437

High

862403

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

862419

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

862435

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

862475

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

862487

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

2

High-throughput

0.437

High

862436

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

862457

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

862459

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

862467

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

831136

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

862377

TAGL
Transgelin

1

1

High-throughput

0.407

High

862456

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

862434

DDIAS
DNA damage-induced apoptosis suppressor protein

1

0

Small-scale

0.251

Low

242028

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

862407

DUS28
Dual specificity phosphatase 28

1

0

High-throughput

0.249

Low

862408

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

862417

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

862422

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.249

Low

862482

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

862490

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

862495

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

862439

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024