Protein: RAP1A
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)

Gene: RAP1A
Organism: Homo sapiens
Interactions: 130
UniProt ID: P62834

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

374009

RAF1
RAF proto-oncogene serine/threonine-protein kinase

6

20

Small-scale

0.940

High

854088

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

4

10

Small-scale

0.902

High

919618

GNDS
Ral guanine nucleotide dissociation stimulator

4

20

Small-scale

0.879

High

542852

BRAF
Serine/threonine-protein kinase B-raf

3

20

Small-scale

0.834

High

919687

RPGF2
Rap guanine nucleotide exchange factor 2

2

20

Small-scale

0.799

High

919655

RASF5
Ras association domain-containing protein 5

2

10

Small-scale

0.786

High

919625

RPGF1
Rap guanine nucleotide exchange factor 1

2

20

Small-scale

0.778

High

919657

RPGF5
Rap guanine nucleotide exchange factor 5

2

20

Small-scale

0.778

High

850733

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

20

Small-scale

0.747

High

876348

AFAD
Afadin

1

20

Small-scale

0.740

High

835037

TSC2
Tuberin

2

14

Small-scale

0.737

High

278773

DNJC8
DnaJ homolog subfamily C member 8

1

3

High-throughput

0.691

High

809252

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

High-throughput

0.691

High

812738

MSS4
Guanine nucleotide exchange factor MSS4

1

4

High-throughput

0.691

High

919646

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.691

High

919681

RGL1
Ral guanine nucleotide dissociation stimulator-like 1

1

20

High-throughput

0.691

High

919674

IFT22
Intraflagellar transport protein 22 homolog

1

18

High-throughput

0.665

High

207516

RGS14
Regulator of G-protein signaling 14

1

12

Small-scale

0.647

High

313171

RPGF3
Rap guanine nucleotide exchange factor 3

1

20

Small-scale

0.647

High

812875

RPGP1
Rap1 GTPase-activating protein 1

1

14

Small-scale

0.647

High

919645

RGDSR
Ral-GDS-related protein

1

20

Small-scale

0.647

High

919653

RPGF6
Rap guanine nucleotide exchange factor 6

1

20

Small-scale

0.647

High

919656

RPGF4
Rap guanine nucleotide exchange factor 4

1

20

Small-scale

0.647

High

919662

ARHG1
Rho guanine nucleotide exchange factor 1

1

20

Small-scale

0.647

High

217719

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

3

3

Small-scale

0.645

High

919651

EXOC6
Exocyst complex component 6

2

3

High-throughput

0.628

High

919661

KIFA3
Kinesin-associated protein 3

2

14

High-throughput

0.628

High

131828

KRIT1
Krev interaction trapped protein 1

1

20

Small-scale

0.621

High

277589

DGKI
Diacylglycerol kinase iota

1

9

Small-scale

0.618

High

350038

RASK
GTPase KRas

1

19

High-throughput

0.618

High

787446

MTOR
Serine/threonine-protein kinase mTOR

1

14

Small-scale

0.618

High

915583

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

919632

RAB35
Ras-related protein Rab-35

1

20

High-throughput

0.618

High

919633

RHEB
GTP-binding protein Rheb

1

20

Small-scale

0.618

High

919640

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

919682

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

19

Small-scale

0.618

High

919677

DUS22
Dual specificity protein phosphatase 22

2

8

High-throughput

0.611

High

919639

CPLX2
Complexin-2

2

0

High-throughput

0.602

High

815854

MTR1A
Melatonin receptor type 1A

2

6

Small-scale

0.601

High

919636

RUN3A
RUN domain-containing protein 3A

1

7

Small-scale

0.579

High

369337

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

848535

CAV2
Caveolin-2

2

9

High-throughput

0.571

High

131228

BIN1
Myc box-dependent-interacting protein 1

1

13

Small-scale

0.561

High

155896

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

7

Small-scale

0.561

High

632238

TNR6
Tumor necrosis factor receptor superfamily member 6

1

8

Small-scale

0.561

High

846738

SMCA2
Probable global transcription activator SNF2L2

1

1

Small-scale

0.561

High

919621

FADD
FAS-associated death domain protein

1

5

Small-scale

0.561

High

919622

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.561

High

919685

FAF1
FAS-associated factor 1

1

11

Small-scale

0.561

High

919668

RADIL
Ras-associating and dilute domain-containing protein

1

20

Small-scale

0.553

High

336454

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

574297

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.536

High

583869

CD53
Leukocyte surface antigen CD53

1

2

High-throughput

0.536

High

666303

NK3R
Neuromedin-K receptor

1

5

High-throughput

0.536

High

672075

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

6

Small-scale

0.536

High

739059

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

6

High-throughput

0.536

High

919643

CACL1
CDK2-associated and cullin domain-containing protein 1

1

9

High-throughput

0.536

High

919650

O2T10
Olfactory receptor 2T10

1

1

High-throughput

0.536

High

919678

CENPM
Centromere protein M

1

2

High-throughput

0.536

High

919684

LIMA1
LIM domain and actin-binding protein 1

1

20

High-throughput

0.536

High

919689

PCDA8
Protocadherin alpha-8

1

1

High-throughput

0.536

High

919630

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.518

High

162005

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

3

High-throughput

0.515

High

919626

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

3

High-throughput

0.515

High

849035

GPC3
Glypican-3

1

0

High-throughput

0.513

High

919635

INSC
Protein inscuteable homolog

1

0

High-throughput

0.513

High

919675

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

919680

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.513

High

919627

ELOA1
Elongin-A

1

9

Small-scale

0.512

High

714174

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.501

High

891054

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

5

Small-scale

0.501

High

919617

1433Z
14-3-3 protein zeta/delta

1

13

Small-scale

0.501

High

157554

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.489

High

217085

NKG2F
NKG2-F type II integral membrane protein

1

1

High-throughput

0.489

High

795728

MAGA3
Melanoma-associated antigen 3

1

2

High-throughput

0.489

High

919644

AGRF3
Adhesion G-protein coupled receptor F3

1

8

High-throughput

0.489

High

919652

PIGO
GPI ethanolamine phosphate transferase 3

1

1

High-throughput

0.489

High

919663

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.489

High

119316

LEG9
Galectin-9

1

7

High-throughput

0.479

High

178469

STX7
Syntaxin-7

1

20

High-throughput

0.479

High

227092

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

384613

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.479

High

433683

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.479

High

487307

ANDR
Androgen receptor

1

17

High-throughput

0.479

High

501938

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.479

High

507937

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.479

High

523653

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

527383

LAMP2
Lysosome-associated membrane glycoprotein 2

1

12

High-throughput

0.479

High

569536

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

669968

MARCS
Myristoylated alanine-rich C-kinase substrate

1

12

High-throughput

0.479

High

726136

BASI
Basigin

1

18

High-throughput

0.479

High

771886

VHL
von Hippel-Lindau disease tumor suppressor

1

3

High-throughput

0.479

High

827902

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

6

High-throughput

0.479

High

908302

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

919616

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

Small-scale

0.479

High

919619

LCP2
Lymphocyte cytosolic protein 2

1

8

Small-scale

0.479

High

919620

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

High-throughput

0.479

High

919623

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

919624

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

5

High-throughput

0.479

High

919628

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

14

High-throughput

0.479

High

919631

KIF14
Kinesin-like protein KIF14

1

12

High-throughput

0.479

High

919638

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

919641

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

19

High-throughput

0.479

High

919642

TAXB1
Tax1-binding protein 1

1

20

High-throughput

0.479

High

919647

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

919649

RN149
E3 ubiquitin-protein ligase RNF149

1

14

High-throughput

0.479

High

919654

DUS19
Dual specificity protein phosphatase 19

1

7

High-throughput

0.479

High

919658

AKAP1
A-kinase anchor protein 1, mitochondrial

1

4

High-throughput

0.479

High

919660

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

919664

CHM4C
Charged multivesicular body protein 4c

1

8

High-throughput

0.479

High

919671

DUS9
Dual specificity protein phosphatase 9

1

7

High-throughput

0.479

High

919683

TRM7
tRNA

1

4

High-throughput

0.479

High

919688

TRAF6
TNF receptor-associated factor 6

1

17

High-throughput

0.479

High

919665

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

496767

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

919648

CD177
CD177 antigen

1

5

Small-scale

0.445

High

919629

RBM39
RNA-binding protein 39

1

10

High-throughput

0.437

High

919659

ESR2
Estrogen receptor beta

1

17

High-throughput

0.437

High

919670

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

919673

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.437

High

919679

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

919672

RM34
Large ribosomal subunit protein bL34m

2

0

High-throughput

0.328

High

263915

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

919637

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

919666

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

919667

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.279

Low

919669

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

919676

DPOE3
DNA polymerase epsilon subunit 3

1

0

High-throughput

0.279

Low

919686

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

919634

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024