Protein: XCT
Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)

Gene: XCT, SLC7A11
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9UPY5

Gene Ontology (top 5):
GO:0003333 - amino acid transmembrane transport
GO:0005886 - plasma membrane
GO:0006749 - glutathione metabolic process
GO:0008542 - visual learning
GO:0009636 - response to toxic substance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

437513

4F2
Amino acid transporter heavy chain SLC3A2

5

10

Small-scale

0.912

High

1348249

SCN3B
Sodium channel regulatory subunit beta-3

1

4

High-throughput

0.691

High

1357796

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

3

High-throughput

0.691

High

555217

CD44
CD44 antigen

3

0

Small-scale

0.619

High

793531

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

349011

RASN
GTPase NRas

2

20

High-throughput

0.584

High

349736

RASH
GTPase HRas

2

17

High-throughput

0.584

High

350692

RASK
GTPase KRas

2

20

High-throughput

0.584

High

991690

KRA11
Keratin-associated protein 1-1

2

1

High-throughput

0.553

High

1216409

KRA13
Keratin-associated protein 1-3

2

1

High-throughput

0.553

High

245443

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.536

High

644701

NKG2C
NKG2-C type II integral membrane protein

1

10

High-throughput

0.536

High

665367

EPHA2
Ephrin type-A receptor 2

1

8

High-throughput

0.536

High

1020153

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

9

High-throughput

0.536

High

1028537

KLRD1
Natural killer cells antigen CD94

1

9

High-throughput

0.536

High

1185650

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

1

High-throughput

0.536

High

1329712

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.536

High

1355536

CLC2D
C-type lectin domain family 2 member D

1

7

High-throughput

0.536

High

1357142

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.536

High

702435

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

968948

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1026666

FADD
FAS-associated death domain protein

1

0

High-throughput

0.513

High

1205567

TMM25
Transmembrane protein 25

1

0

High-throughput

0.513

High

1262305

ITLN1
Intelectin-1

1

0

High-throughput

0.513

High

678586

MK04
Mitogen-activated protein kinase 4

1

2

High-throughput

0.489

High

1133275

HECD3
E3 ubiquitin-protein ligase HECTD3

1

4

High-throughput

0.489

High

1218792

SFPA2
Pulmonary surfactant-associated protein A2

1

3

High-throughput

0.489

High

120717

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

206174

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

339144

EGFR
Epidermal growth factor receptor

1

6

Small-scale

0.479

High

434082

LYN
Tyrosine-protein kinase Lyn

1

5

High-throughput

0.479

High

436577

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

507316

LAMP1
Lysosome-associated membrane glycoprotein 1

1

11

High-throughput

0.479

High

545702

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

564743

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

670285

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.479

High

852680

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

892685

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

894596

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

901058

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

901276

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

913193

ARF6
ADP-ribosylation factor 6

1

7

High-throughput

0.479

High

916080

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

925739

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

951463

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

975116

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

1076818

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

1183614

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1198712

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

6

Small-scale

0.479

High

1269258

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

1296767

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

1330994

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1335399

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

154068

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

119566

LEG9
Galectin-9

1

11

High-throughput

0.437

High

146654

SOCS2
Suppressor of cytokine signaling 2

1

5

Small-scale

0.437

High

214415

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.437

High

599750

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

Small-scale

0.437

High

895322

RAB2A
Ras-related protein Rab-2A

1

12

High-throughput

0.437

High

896399

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

1

Small-scale

0.437

High

941587

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

1203910

TMM17
Transmembrane protein 17

1

4

High-throughput

0.437

High

1081263

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

1314496

IFT27
Intraflagellar transport protein 27 homolog

1

14

High-throughput

0.407

High

1291609

OTUB1
Ubiquitin thioesterase OTUB1

5

0

Small-scale

0.371

High

314499

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

1020987

TRAF2
TNF receptor-associated factor 2

1

0

High-throughput

0.279

Low

1083619

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1157117

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

1233745

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

1246533

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

1355735

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.279

Low

1019386

TRI26
Tripartite motif-containing protein 26

1

0

Small-scale

0.249

Low

1284273

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1311713

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024