Protein: PEAK1
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)

Gene: PEAK1
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q9H792

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

160783

AURKA
Aurora kinase A

3

18

High-throughput

0.861

High

350556

RASK
GTPase KRas

3

10

High-throughput

0.827

High

914361

RB11A
Ras-related protein Rab-11A

2

2

High-throughput

0.754

High

915979

RHOB
Rho-related GTP-binding protein RhoB

2

19

High-throughput

0.754

High

738051

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

7

15

High-throughput

0.746

High

906137

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

5

15

High-throughput

0.723

High

802730

CRK
Adapter molecule crk

5

17

Small-scale

0.714

High

380863

S100B
Protein S100-B

1

12

High-throughput

0.691

High

782826

CSK
Tyrosine-protein kinase CSK

1

15

High-throughput

0.691

High

924867

GRB2
Growth factor receptor-bound protein 2

3

18

High-throughput

0.675

High

209171

NCK2
Cytoplasmic protein NCK2

3

20

High-throughput

0.667

High

1332898

SH22A
SH2 domain-containing protein 2A

3

20

High-throughput

0.667

High

1332903

CARD8
Caspase recruitment domain-containing protein 8

3

2

High-throughput

0.667

High

905118

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

982503

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

1332896

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

18

Small-scale

0.647

High

1088142

DDR2
Discoidin domain-containing receptor 2

1

19

High-throughput

0.646

High

666175

SHC1
SHC-transforming protein 1

2

14

High-throughput

0.628

High

802905

CRKL
Crk-like protein

2

20

High-throughput

0.628

High

120644

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

338986

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

374878

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

High-throughput

0.618

High

385530

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.618

High

411858

LCK
Tyrosine-protein kinase Lck

1

11

High-throughput

0.618

High

434012

LYN
Tyrosine-protein kinase Lyn

1

15

High-throughput

0.618

High

435763

IGF1R
Insulin-like growth factor 1 receptor

1

18

High-throughput

0.618

High

436511

RHOC
Rho-related GTP-binding protein RhoC

1

18

High-throughput

0.618

High

438534

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

508196

FGFR1
Fibroblast growth factor receptor 1

1

15

High-throughput

0.618

High

545621

RAC2
Ras-related C3 botulinum toxin substrate 2

1

17

High-throughput

0.618

High

557254

PGFRA
Platelet-derived growth factor receptor alpha

1

11

High-throughput

0.618

High

592499

RAB5A
Ras-related protein Rab-5A

1

9

High-throughput

0.618

High

608132

FGFR4
Fibroblast growth factor receptor 4

1

15

High-throughput

0.618

High

665432

EPHA3
Ephrin type-A receptor 3

1

12

High-throughput

0.618

High

665659

EPHB2
Ephrin type-B receptor 2

1

11

High-throughput

0.618

High

793475

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

835522

GSK3A
Glycogen synthase kinase-3 alpha

1

11

High-throughput

0.618

High

835996

GSK3B
Glycogen synthase kinase-3 beta

1

10

High-throughput

0.618

High

845737

RAB9A
Ras-related protein Rab-9A

1

6

High-throughput

0.618

High

852622

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

876504

AFAD
Afadin

1

6

High-throughput

0.618

High

892033

ACTB
Actin, cytoplasmic 1

1

16

High-throughput

0.618

High

892599

RAC3
Ras-related C3 botulinum toxin substrate 3

1

19

High-throughput

0.618

High

894437

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

895274

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.618

High

900910

RHOA
Transforming protein RhoA

1

19

High-throughput

0.618

High

901244

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

925619

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

951343

RHOG
Rho-related GTP-binding protein RhoG

1

18

High-throughput

0.618

High

1021464

ANK3
Ankyrin-3

1

4

High-throughput

0.618

High

1066707

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.618

High

1069974

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

3

High-throughput

0.618

High

1070398

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.618

High

1083894

NTRK2
BDNF/NT-3 growth factors receptor

1

19

High-throughput

0.618

High

1183555

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1269226

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1330409

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.618

High

1332897

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1332902

ALK
ALK tyrosine kinase receptor

1

15

High-throughput

0.618

High

1219963

BBS7
Bardet-Biedl syndrome 7 protein

2

0

High-throughput

0.602

High

825743

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.587

High

1129590

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.586

High

507238

LAMP1
Lysosome-associated membrane glycoprotein 1

2

4

High-throughput

0.584

High

547219

EZRI
Ezrin

2

8

High-throughput

0.584

High

1255893

DQX1
ATP-dependent RNA helicase DQX1

2

6

High-throughput

0.574

High

1312166

AASD1
Alanyl-tRNA editing protein Aarsd1

2

3

High-throughput

0.574

High

1332904

PCDBB
Protocadherin beta-11

2

4

High-throughput

0.574

High

1319369

RHG39
Rho GTPase-activating protein 39

2

8

High-throughput

0.571

High

318224

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.553

High

434286

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

14

High-throughput

0.553

High

564687

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.553

High

592014

RAB4A
Ras-related protein Rab-4A

1

6

High-throughput

0.553

High

872489

EPHA5
Ephrin type-A receptor 5

1

15

High-throughput

0.553

High

884595

RAB25
Ras-related protein Rab-25

1

5

High-throughput

0.553

High

940564

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.553

High

968486

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

19

High-throughput

0.553

High

1072599

EPHA7
Ephrin type-A receptor 7

1

9

High-throughput

0.553

High

1076761

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.553

High

1296735

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.553

High

1330919

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.553

High

515943

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

3

High-throughput

0.536

High

525060

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

813751

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

984662

CALD1
Caldesmon

1

20

High-throughput

0.536

High

1052319

SRC8
Src substrate cortactin

1

7

High-throughput

0.536

High

1283457

SPSB4
SPRY domain-containing SOCS box protein 4

1

12

High-throughput

0.536

High

1332607

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

484200

CALM3
Calmodulin-3

1

8

High-throughput

0.514

High

1029323

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1304341

SORT
Sortilin

1

0

High-throughput

0.513

High

1332905

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.513

High

882572

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

Small-scale

0.500

High

207185

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

4

High-throughput

0.489

High

622975

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.489

High

799576

MMP13
Collagenase 3

1

2

High-throughput

0.489

High

1128025

TOIP1
Torsin-1A-interacting protein 1

1

1

High-throughput

0.489

High

1216301

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

3

High-throughput

0.489

High

1329024

CAD23
Cadherin-23

1

2

High-throughput

0.489

High

1332899

FBLN5
Fibulin-5

1

4

High-throughput

0.489

High

213007

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

279712

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

430339

PROF1
Profilin-1

1

2

High-throughput

0.479

High

522196

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

567272

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

575850

VINC
Vinculin

1

6

High-throughput

0.479

High

577066

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

5

High-throughput

0.479

High

647282

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

670217

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

683715

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

684328

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

716772

CTNA1
Catenin alpha-1

1

5

High-throughput

0.479

High

823495

PAXI
Paxillin

1

13

High-throughput

0.479

High

840580

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

910032

1433E
14-3-3 protein epsilon

1

11

High-throughput

0.479

High

913114

ARF6
ADP-ribosylation factor 6

1

5

High-throughput

0.479

High

927534

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

975038

CAV1
Caveolin-1

1

2

High-throughput

0.479

High

990935

ZO1
Tight junction protein ZO-1

1

3

High-throughput

0.479

High

1017799

STX4
Syntaxin-4

1

5

High-throughput

0.479

High

1036085

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1080785

ZYX
Zyxin

1

11

High-throughput

0.479

High

1110091

AR13B
ADP-ribosylation factor-like protein 13B

1

8

High-throughput

0.479

High

1170244

PEAK3
Protein PEAK3

1

3

Small-scale

0.479

High

1271254

GOGA1
Golgin subfamily A member 1

1

12

High-throughput

0.479

High

1326743

WWTR1
WW domain-containing transcription regulator protein 1

1

18

High-throughput

0.479

High

1332900

ZO2
Tight junction protein ZO-2

1

3

High-throughput

0.479

High

1332901

ANC2
Anaphase-promoting complex subunit 2

1

10

High-throughput

0.479

High

178784

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

205990

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

329948

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

527794

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.437

High

1072824

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

3

High-throughput

0.437

High

1084187

OCLN
Occludin

1

1

High-throughput

0.437

High

1087846

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

4

High-throughput

0.437

High

1148220

RNF43
E3 ubiquitin-protein ligase RNF43

1

5

High-throughput

0.437

High

1188396

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.437

High

1230373

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.437

High

1269623

ESR2
Estrogen receptor beta

1

13

High-throughput

0.437

High

1032616

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.407

High

132032

VMA5A
von Willebrand factor A domain-containing protein 5A

2

0

High-throughput

0.328

High

179261

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

132592

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

305631

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

1152103

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1283064

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024