Protein: CI
Transcriptional activator cubitus interruptus (Transcriptional activator ci) (ci form of 155 kDa) (ci-155) (ci full-length protein) (ciFL) [Cleaved into: Transcriptional repressor cubitus interruptus (Transcriptional repressor ci) (ci C-terminally truncated form) (ci form of 75 kDa) (ci-75)]

Gene: CI
Organism: Drosophila melanogaster
Interactions: 217
UniProt ID: P19538

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

624278

FUSED
Serine/threonine-protein kinase fused

9

6

Small-scale

0.974

High

624275

CI
Transcriptional activator cubitus interruptus

2

18

Small-scale

0.837

High

624295

KC1A
Casein kinase I isoform alpha

3

8

Small-scale

0.814

High

303769

DCO
Discs overgrown protein kinase

2

3

Small-scale

0.800

High

553472

KAPC1
cAMP-dependent protein kinase catalytic subunit 1

2

4

Small-scale

0.775

High

624392

Q9VG38
Suppressor of fused homolog

19

11

Small-scale

0.766

High

195757

COS
Kinesin-like protein costa

17

8

Small-scale

0.765

High

624390

RDX
Protein roadkill

9

5

Small-scale

0.756

High

613904

SGG
Protein kinase shaggy

2

4

Small-scale

0.713

High

121970

M9PH39
histone acetyltransferase

5

16

Small-scale

0.711

High

624383

Q9VDE3
LD08669p

5

8

Small-scale

0.704

High

624285

ZFH2
Zinc finger protein 2

1

12

High-throughput

0.698

High

624300

SMO
Protein smoothened

3

1

Small-scale

0.640

High

624372

Q9V455
Importin subunit alpha

2

7

Small-scale

0.636

High

624306

CSKP
Peripheral plasma membrane protein CASK

1

1

High-throughput

0.625

High

624434

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

11

Small-scale

0.624

High

144546

O01368
histone acetyltransferase

2

15

Small-scale

0.620

High

624353

HIPPO
Serine/threonine-protein kinase hippo

1

13

Small-scale

0.618

High

68358

OBSCN
Protein Obscurin

1

1

High-throughput

0.590

High

624328

MED13
Mediator of RNA polymerase II transcription subunit 13

2

0

Small-scale

0.588

High

620683

SXL
Protein sex-lethal

2

2

Small-scale

0.584

High

624307

CUL1
Cullin homolog 1

2

20

Small-scale

0.584

High

624416

Q9VRV8
Transportin-1

2

20

Small-scale

0.584

High

624332

Q86BH2
Grunge, isoform C

1

1

Small-scale

0.552

High

624374

Q9V474
BcDNA.LD26519

1

1

Small-scale

0.552

High

52873

A1Z7C4
LDL receptor protein 1, isoform G

1

10

High-throughput

0.541

High

234665

MSTAA
SET domain-containing protein SmydA-8, isoform A

1

3

High-throughput

0.541

High

235190

HTH
Homeobox protein homothorax

1

3

High-throughput

0.541

High

444042

PRD
Segmentation protein paired

1

6

High-throughput

0.541

High

532114

KNIR
Zygotic gap protein knirps

1

7

High-throughput

0.541

High

624277

MYOD
Myogenic-determination protein

1

6

High-throughput

0.541

High

624281

SLIT
Protein slit

1

17

High-throughput

0.541

High

624289

FTZF1
Nuclear hormone receptor FTZ-F1

1

10

High-throughput

0.541

High

624296

CCNE
G1/S-specific cyclin-E

1

1

High-throughput

0.541

High

624299

P91634
phosphatidylinositol 3-kinase

1

2

High-throughput

0.541

High

624308

NOC
Zinc finger protein Noc

1

4

High-throughput

0.541

High

624316

SMG1
Serine/threonine-protein kinase Smg1

1

3

High-throughput

0.541

High

624318

BRDH
Bromodomain-containing protein homolog

1

3

High-throughput

0.541

High

624320

Q7K012
Brahma associated protein 55kD

1

4

High-throughput

0.541

High

624325

JING
Zinc finger protein jing

1

19

High-throughput

0.541

High

624363

M3KSL
Mitogen-activated protein kinase kinase kinase

1

3

High-throughput

0.541

High

624366

CEG1A
Centaurin-gamma-1A

1

2

High-throughput

0.541

High

624369

Q9U8L5
Dorsocross1, isoform A

1

6

High-throughput

0.541

High

624397

ELBOW
Zinc finger protein Elbow

1

3

High-throughput

0.541

High

624403

Q9VMR2
LP04777p

1

6

High-throughput

0.541

High

624406

Q9VP57
LD15904p

1

20

High-throughput

0.541

High

624428

ZSWM8
Zinc finger SWIM domain-containing protein 8 homolog

1

7

High-throughput

0.541

High

624430

ATR
Serine/threonine-protein kinase ATR

1

3

High-throughput

0.541

High

624432

AJUBA
LIM domain-containing protein jub

1

12

High-throughput

0.541

High

624440

ANM7
Protein arginine N-methyltransferase 7

1

2

High-throughput

0.541

High

624444

Q9W3D1
Chromatin assembly factor 1, p180 subunit

1

3

High-throughput

0.541

High

624445

Q9W475
LP17541p

1

1

High-throughput

0.541

High

624310

Q27279
Suppressor of fused homolog

2

11

High-throughput

0.534

High

57279

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.518

High

235035

NOI
Splicing factor 3A subunit 3

1

0

High-throughput

0.518

High

624287

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.518

High

624304

SNAP
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.518

High

624351

Q8T0L3
E1 ubiquitin-activating enzyme

1

0

High-throughput

0.518

High

624402

KDM5
Lysine-specific demethylase 5

1

0

High-throughput

0.518

High

624422

PGM
Phosphoglucomutase 1

1

0

High-throughput

0.518

High

624431

Q9VXI1
L-gulonate 3-dehydrogenase

1

0

High-throughput

0.518

High

624446

NU931
Nuclear pore complex protein Nup93-1

1

0

High-throughput

0.518

High

402254

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.508

High

95137

E1JI40
Vermiform, isoform I

1

5

High-throughput

0.494

High

305606

FRIZ3
Frizzled-3

1

1

High-throughput

0.494

High

535771

LAMB1
Laminin subunit beta-1

1

19

High-throughput

0.494

High

624286

CLH
Clathrin heavy chain

1

2

High-throughput

0.494

High

624319

Q7JZ37
WD repeat-containing protein 89

1

3

High-throughput

0.494

High

624322

Q7K0W0
LD27413p

1

1

High-throughput

0.494

High

624326

Q7KMM4
Glucosidase II subunit alpha

1

1

High-throughput

0.494

High

624327

Q7KN74
Tetratricopeptide repeat domain 7, isoform A

1

5

High-throughput

0.494

High

624331

Q86B58
IP10114p

1

2

High-throughput

0.494

High

624378

Q9VAU5
Uncharacterized protein

1

4

High-throughput

0.494

High

624380

KL98A
Kinesin-like protein Klp98A

1

3

High-throughput

0.494

High

624384

PERC
Chorion peroxidase

1

3

High-throughput

0.494

High

624389

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.494

High

624396

Q9VJ80
LD42267p

1

3

High-throughput

0.494

High

624401

TIG
Tiggrin

1

4

High-throughput

0.494

High

624413

Q9VR69
Chitin deacetylase-like 4

1

5

High-throughput

0.494

High

624417

Q9VSK6
Uncharacterized protein, isoform C

1

9

High-throughput

0.494

High

624425

Q9VW91
RE65123p

1

14

High-throughput

0.494

High

624426

Q9VW93
RE24410p

1

8

High-throughput

0.494

High

624438

Q9W0R8
Phosphatidylinositol 4-kinase beta

1

2

High-throughput

0.494

High

624294

OAZ
Ornithine decarboxylase antizyme

1

0

High-throughput

0.486

High

69126

A8JTM7
Megalin, isoform A

1

20

High-throughput

0.481

High

98461

F0JAK5
LD31195p

1

7

High-throughput

0.481

High

121040

M9PEP8
Muscle-specific protein 300 kDa, isoform M

1

5

High-throughput

0.481

High

624282

SUZ2
Protein suppressor 2 of zeste

1

17

High-throughput

0.481

High

624302

Q0E8Q6
Uncharacterized protein, isoform B

1

2

High-throughput

0.481

High

624313

Q2QBM1
Malic enzyme

1

1

High-throughput

0.481

High

624323

MEPCE
7SK snRNA methylphosphate capping enzyme bin3

1

2

High-throughput

0.481

High

624348

Q8SYC0
Bruno 1, isoform D

1

2

High-throughput

0.481

High

624393

Q9VGZ6
Rfx, isoform J

1

1

High-throughput

0.481

High

624408

Q9VPL9
FI24801p1

1

7

High-throughput

0.481

High

624419

Q9VSL5
Glutathione S transferase O2, isoform A

1

1

High-throughput

0.481

High

624439

Q9W1Q8
Translation initiation factor eIF2B subunit delta

1

1

High-throughput

0.481

High

624443

Q9W2J2
Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, isoform A

1

10

High-throughput

0.481

High

624284

UBCD1
Ubiquitin-conjugating enzyme E2-17 kDa

1

0

Small-scale

0.480

High

119478

M9NFQ7
RNA-binding Fox protein 1, isoform H

1

1

Small-scale

0.479

High

583654

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

Small-scale

0.479

High

615046

PTC
Protein patched

1

1

Small-scale

0.479

High

624280

PP2A
Serine/threonine-protein phosphatase PP2A

1

9

Small-scale

0.479

High

624288

CROC
Fork head domain-containing protein crocodile

1

5

Small-scale

0.479

High

624290

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

1

2

Small-scale

0.479

High

624291

SQH
Myosin regulatory light chain sqh

1

1

Small-scale

0.479

High

624292

HYD
E3 ubiquitin-protein ligase hyd

1

12

Small-scale

0.479

High

624305

STAT
Signal transducer and transcription activator

1

3

Small-scale

0.479

High

624314

YAP1
Transcriptional coactivator yorkie

1

13

Small-scale

0.479

High

624335

TAD2B
Transcriptional adapter 2b

1

3

Small-scale

0.479

High

624337

Q8IP45
Cullin 3, isoform F

1

20

Small-scale

0.479

High

624355

HDAC1
Histone deacetylase HDAC1

1

10

Small-scale

0.479

High

624424

MED12
Mediator of RNA polymerase II transcription subunit 12

1

5

Small-scale

0.479

High

624449

R9PY16
Ubiquitin-like domain-containing protein

1

7

Small-scale

0.479

High

624293

ACT3
Actin-57B

1

4

High-throughput

0.464

High

624311

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit 2

1

3

High-throughput

0.464

High

624379

Q9VB22
LD33695p

1

7

High-throughput

0.464

High

624371

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.460

High

305457

O77430
GEO01111p1

1

0

Small-scale

0.458

High

624381

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.458

High

624394

Q9VHI1
Hyrax

1

0

Small-scale

0.458

High

624395

Q9VIE7
GMP synthase

1

0

Small-scale

0.458

High

305329

O77291
Kakapo

1

5

High-throughput

0.457

High

624298

MSTAB
SET domain-containing protein SmydA-8, isoform B

1

3

High-throughput

0.457

High

624303

Q0E8X6
Translation initiation factor eIF2B subunit delta

1

1

High-throughput

0.457

High

624309

OMB
Optomotor-blind protein

1

7

High-throughput

0.457

High

624334

Q86PC3
RE13301p

1

10

High-throughput

0.457

High

624340

Q8IQX7
Beadex, isoform B

1

16

High-throughput

0.457

High

624343

Q8MSG0
GM15173p

1

2

High-throughput

0.457

High

624346

Q8SXA8
GH18470p

1

1

High-throughput

0.457

High

624347

Q8SXM3
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.457

High

624349

Q8SYW8
RE30177p

1

2

High-throughput

0.457

High

624357

Q95SN5
GH12891p

1

10

High-throughput

0.457

High

624359

Q95TK6
LD44304p

1

7

High-throughput

0.457

High

624360

Q95TP4
LD33277p

1

2

High-throughput

0.457

High

624367

Q9TXC7
Suppressor of zeste 2 protein

1

14

High-throughput

0.457

High

624368

Q9U1K2
RFX transcription factor

1

1

High-throughput

0.457

High

624373

Q9V472
DLim1

1

15

High-throughput

0.457

High

624391

Q9VG31
Malic enzyme

1

1

High-throughput

0.457

High

624436

Q9VZU6
BTB-VII protein domain

1

1

High-throughput

0.457

High

624448

Q9Y1L3
Kismet

1

5

High-throughput

0.457

High

624407

Q9VPI3
Chitin deacetylase-like 5, isoform B

1

7

High-throughput

0.451

High

54752

A1Z8W9
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.439

High

69244

A8JUU3
Secretory 16, isoform D

1

3

High-throughput

0.439

High

94985

E1JGS7
Jitterbug, isoform I

1

4

High-throughput

0.439

High

95078

E1JH68
Pre-mRNA cleavage complex 2 protein Pcf11

1

1

High-throughput

0.439

High

95596

E3CTN7
RE13835p

1

1

High-throughput

0.439

High

118186

M9NCL3
Chitin deacetylase-like 5, isoform G

1

5

High-throughput

0.439

High

624312

Q2M1E6
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

1

High-throughput

0.439

High

624329

Q7KV70
Karst, isoform C

1

4

High-throughput

0.439

High

624330

Q7KW16
Mitochondrial poly(A) polymerase, isoform B

1

1

High-throughput

0.439

High

624338

Q8IPH5
CD109 antigen

1

1

High-throughput

0.439

High

624339

Q8IPP3
Canoe, isoform D

1

3

High-throughput

0.439

High

624342

Q8MR04
LP02978p

1

5

High-throughput

0.439

High

624385

Q9VEJ9
Curly Su

1

3

High-throughput

0.439

High

624387

Q9VEM8
Uncharacterized protein, isoform A

1

1

High-throughput

0.439

High

624399

Q9VM00
Rap GTPase activating protein 1, isoform D

1

1

High-throughput

0.439

High

624410

Q9VPV8
IA-2 protein tyrosine phosphatase, isoform C

1

2

High-throughput

0.439

High

624423

Q9VW34
FI03450p

1

5

High-throughput

0.439

High

624441

Q9W244
Plexus, isoform A

1

1

High-throughput

0.439

High

624450

X2JE09
Terribly reduced optic lobes, isoform AV

1

4

High-throughput

0.439

High

624451

X2JE93
Kelch-like protein diablo

1

2

High-throughput

0.439

High

624358

Q95TD3
GH01083p

1

0

High-throughput

0.438

High

624375

PPO2
Phenoloxidase 2

1

0

High-throughput

0.438

High

624377

Q9VAH2
LD33331p

1

0

High-throughput

0.438

High

624382

DANR
Protein distal antenna-related

1

0

High-throughput

0.438

High

624433

Q9VY91
Programmed cell death protein 4

1

0

High-throughput

0.438

High

2693

A0A0B4LFE6
Pre-mRNA cleavage complex 2 protein Pcf11

1

1

High-throughput

0.417

High

69232

A8JUU1
Secretory 16, isoform E

1

1

High-throughput

0.417

High

94974

E1JGP0
LD04994p1

1

4

High-throughput

0.417

High

95492

E2QC61
RNA methyltransferase

1

2

High-throughput

0.417

High

235027

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

3

High-throughput

0.417

High

624321

Q7K0L2
Kelch-like protein diablo

1

3

High-throughput

0.417

High

624333

Q86P23
RE22242p

1

5

High-throughput

0.417

High

624341

Q8MQR5
GH26549p

1

2

High-throughput

0.417

High

624344

Q8MT50
RE26705p

1

3

High-throughput

0.417

High

624345

Q8SX49
RE05031p

1

1

High-throughput

0.417

High

624350

Q8T015
LD40095p

1

1

High-throughput

0.417

High

624352

Q8T0L7
GH23617p

1

1

High-throughput

0.417

High

624354

Q8T4A1
AT08349p

1

1

High-throughput

0.417

High

624361

Q95TT5
LD24616p

1

10

High-throughput

0.417

High

624362

Q95U66
GH03118p

1

3

High-throughput

0.417

High

624365

Q9NFR7
Rapsynoid

1

7

High-throughput

0.417

High

624370

Q9U8Q0
Plexus

1

1

High-throughput

0.417

High

624386

SUR8
Leucine-rich repeat protein soc-2 homolog

1

2

High-throughput

0.417

High

624398

Q9VLZ0
CD109 antigen

1

1

High-throughput

0.417

High

624400

Q9VM02
Rap GTPase activating protein 1, isoform E

1

1

High-throughput

0.417

High

624405

Q9VN68
Moesin/ezrin/radixin homolog 1

1

1

High-throughput

0.417

High

624418

Q9VSL4
Glutathione S transferase O2, isoform B

1

1

High-throughput

0.417

High

624427

Q9VW94
RE22940p

1

5

High-throughput

0.417

High

624429

PP2B3
Serine/threonine-protein phosphatase 2B catalytic subunit 3

1

3

High-throughput

0.417

High

624435

Q9VZQ3
Karst, isoform A

1

4

High-throughput

0.417

High

624364

Q961T5
GH08783p

1

1

High-throughput

0.348

High

624276

GLNA2
Glutamine synthetase 2 cytoplasmic

1

0

High-throughput

0.282

High

624279

NRT
Neurotactin

1

0

High-throughput

0.282

High

624283

PIP1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II

1

0

High-throughput

0.282

High

624297

FUCTC
Alpha-(1,3)-fucosyltransferase C

1

0

High-throughput

0.282

High

624301

LYSB
Lysozyme B

1

0

High-throughput

0.282

High

624317

Q7JUF8
alpha-1,2-Mannosidase

1

0

High-throughput

0.282

High

624324

Q7K511
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.282

High

624336

NOL6
Nucleolar protein 6

1

0

High-throughput

0.282

High

624388

Q9VF24
Crossveinless d

1

0

High-throughput

0.282

High

624404

Q9VMX7
Jonah 25Bi

1

0

High-throughput

0.282

High

624409

Q9VPM1
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

1

0

High-throughput

0.282

High

624411

U518
FHIP family protein CG3558

1

0

High-throughput

0.282

High

624414

Q9VRF3
LD38858p

1

0

High-throughput

0.282

High

624415

Q9VRG8
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.282

High

624421

Q9VTU9
Inositol oxygenase

1

0

High-throughput

0.282

High

624437

Q9W0H1
Uncharacterized protein, isoform A

1

0

High-throughput

0.282

High

624442

WDP
Protein windpipe

1

0

High-throughput

0.282

High

624447

EXT3
Exostosin-3

1

0

High-throughput

0.282

High

624376

EXOC3
Exocyst complex component 3

1

0

High-throughput

0.265

Low

624412

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.257

Low

117964

M9MRK7
Tweek, isoform H

1

0

High-throughput

0.251

Low

624315

Q6ILC3
HDC09785

1

0

High-throughput

0.238

Low

624356

Q95S84
GM06086p

1

0

High-throughput

0.238

Low

624420

PLOD
Procollagen-lysine,2-oxoglutarate 5-dioxygenase

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025