Protein: IL4RA
Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]

Gene: IL4RA, IL4R
Organism: Homo sapiens
Interactions: 49
UniProt ID: P24394

Gene Ontology (top 5):
GO:0002532 - production of molecular mediator involved in inflammatory response
GO:0002639 - positive regulation of immunoglobulin production
GO:0004896 - cytokine receptor activity
GO:0004913 - interleukin-4 receptor activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

396848

IL4
Interleukin-4

10

3

Small-scale

0.973

High

622726

IL13
Interleukin-13

6

3

Small-scale

0.941

High

622729

STAT6
Signal transducer and activator of transcription 6

5

20

Small-scale

0.710

High

616738

JAK1
Tyrosine-protein kinase JAK1

4

20

Small-scale

0.700

High

622722

PTN6
Tyrosine-protein phosphatase non-receptor type 6

4

20

Small-scale

0.680

High

622720

IL4RA
Interleukin-4 receptor subunit alpha

1

14

Small-scale

0.647

High

622724

TYK2
Non-receptor tyrosine-protein kinase TYK2

2

20

High-throughput

0.628

High

622740

KCNT2
Potassium channel subfamily T member 2

2

1

High-throughput

0.628

High

622741

ARHG8
Neuroepithelial cell-transforming gene 1 protein

2

8

High-throughput

0.628

High

622742

PKHH3
Pleckstrin homology domain-containing family H member 3

2

1

High-throughput

0.628

High

622752

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

2

9

High-throughput

0.628

High

622725

IL2RG
Cytokine receptor common subunit gamma

2

16

Small-scale

0.611

High

622739

RHDF2
Inactive rhomboid protein 2

2

0

High-throughput

0.602

High

622748

TR19L
Tumor necrosis factor receptor superfamily member 19L

2

0

High-throughput

0.602

High

622754

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

2

0

High-throughput

0.602

High

622723

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.595

High

622732

I13R1
Interleukin-13 receptor subunit alpha-1

2

16

Small-scale

0.584

High

301176

RHBT3
Rho-related BTB domain-containing protein 3

2

16

High-throughput

0.574

High

622734

GOGA2
Golgin subfamily A member 2

2

4

High-throughput

0.574

High

622735

STX5
Syntaxin-5

2

4

High-throughput

0.574

High

622755

ZDHC9
Palmitoyltransferase ZDHHC9

2

4

High-throughput

0.574

High

159891

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

4

Small-scale

0.561

High

256850

SOCS5
Suppressor of cytokine signaling 5

1

20

Small-scale

0.561

High

312481

ARI2
E3 ubiquitin-protein ligase ARIH2

1

7

High-throughput

0.541

High

121445

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

3

High-throughput

0.536

High

383616

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.536

High

622728

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.536

High

622737

AVR2B
Activin receptor type-2B

1

1

High-throughput

0.536

High

622746

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

1

Small-scale

0.516

High

238358

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.515

High

622721

TNR5
Tumor necrosis factor receptor superfamily member 5

1

5

Small-scale

0.515

High

622730

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.515

High

622727

IRS1
Insulin receptor substrate 1

1

8

Small-scale

0.501

High

622731

RACK1
Small ribosomal subunit protein RACK1

1

5

Small-scale

0.501

High

622733

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

19

Small-scale

0.501

High

622738

I13R2
Interleukin-13 receptor subunit alpha-2

1

18

Small-scale

0.501

High

277560

DHRS3
Short-chain dehydrogenase/reductase 3

1

2

High-throughput

0.489

High

537598

NCF1
Neutrophil cytosol factor 1

1

13

Small-scale

0.479

High

622736

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.479

High

622747

KAT5
Histone acetyltransferase KAT5

1

2

Small-scale

0.479

High

622751

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

8

Small-scale

0.479

High

622753

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

622745

PIBF1
Progesterone-induced-blocking factor 1

1

0

Small-scale

0.458

High

345949

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.445

High

622743

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

2

0

High-throughput

0.328

High

622749

PRR11
Proline-rich protein 11

2

0

High-throughput

0.328

High

622744

DCAKD
Dephospho-CoA kinase domain-containing protein

1

0

High-throughput

0.279

Low

622750

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024