Protein: THIM
3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) (T1)

Gene: THIM, ACAA2
Organism: Homo sapiens
Interactions: 86
UniProt ID: P42765

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003985 - acetyl-CoA C-acetyltransferase activity
GO:0003986 - acetyl-CoA hydrolase activity
GO:0003988 - acetyl-CoA C-acyltransferase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

790273

TR61B
tRNA

3

1

High-throughput

0.656

High

790249

SYLM
Leucine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

790236

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

2

0

High-throughput

0.585

High

226761

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

790252

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

300726

GLSK
Glutaminase kidney isoform, mitochondrial

1

2

High-throughput

0.536

High

505944

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

520696

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

4

High-throughput

0.536

High

679431

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

2

High-throughput

0.536

High

790253

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

2

High-throughput

0.536

High

790255

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

790258

ACD10
Acyl-CoA dehydrogenase family member 10

1

1

High-throughput

0.536

High

790266

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.536

High

790269

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

790272

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.536

High

790274

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

790233

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

2

5

High-throughput

0.533

High

790234

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.513

High

790239

SYHM
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

790241

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.513

High

790242

KIME
Mevalonate kinase

1

0

High-throughput

0.513

High

790244

FOLC
Folylpolyglutamate synthase, mitochondrial

1

0

High-throughput

0.513

High

790260

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

790263

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

790268

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.513

High

790270

MGME1
Mitochondrial genome maintenance exonuclease 1

1

0

High-throughput

0.513

High

790284

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.513

High

790289

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

790291

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.513

High

282842

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

6

High-throughput

0.489

High

584562

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

2

High-throughput

0.489

High

675130

CLIP1
CAP-Gly domain-containing linker protein 1

1

3

High-throughput

0.489

High

790245

CDK18
Cyclin-dependent kinase 18

1

3

High-throughput

0.489

High

790278

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

2

High-throughput

0.489

High

346154

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

414805

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

499597

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

590687

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

790235

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

790247

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

790250

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

790257

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

790283

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

790251

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.464

High

154003

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

446534

SNRPA
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.460

High

790282

ZFYV1
Zinc finger FYVE domain-containing protein 1

1

0

Small-scale

0.458

High

790288

TES
Testin

1

0

High-throughput

0.458

High

394279

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

496499

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

790248

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

5

Small-scale

0.445

High

790261

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

1

Small-scale

0.445

High

213890

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

4

Small-scale

0.439

High

148494

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

196274

PJA2
E3 ubiquitin-protein ligase Praja-2

1

3

Small-scale

0.437

High

214130

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.437

High

384437

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

548067

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

3

Small-scale

0.437

High

569339

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.437

High

790238

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.437

High

790243

TLE2
Transducin-like enhancer protein 2

1

5

High-throughput

0.437

High

790256

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

6

Small-scale

0.437

High

790262

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

790264

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

790279

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

790280

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

1

High-throughput

0.437

High

790281

WDR76
WD repeat-containing protein 76

1

10

High-throughput

0.437

High

790285

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

790286

HDAC6
Histone deacetylase 6

1

4

High-throughput

0.437

High

790287

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

790290

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

High-throughput

0.437

High

562011

UD2B7
UDP-glucuronosyltransferase 2B7

1

1

Small-scale

0.407

High

790276

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

790254

PPCEL
Prolyl endopeptidase-like

3

0

High-throughput

0.347

High

206333

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.282

High

121452

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.279

Low

125981

UPK1A
Uroplakin-1a

1

0

High-throughput

0.279

Low

790237

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.279

Low

790240

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

790246

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low

790259

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

790265

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

790267

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

790275

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

790277

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.279

Low

790271

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024