Protein: TBX5
T-box transcription factor TBX5 (T-box protein 5)

Gene: TBX5
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q99593

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001708 - cell fate specification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

858120

NKX25
Homeobox protein Nkx-2.5

2

20

Small-scale

0.825

High

1304836

BAIP2
BAR/IMD domain-containing adapter protein 2

3

0

High-throughput

0.625

High

595631

HXA5
Homeobox protein Hox-A5

1

20

High-throughput

0.618

High

1304812

TBX5
T-box transcription factor TBX5

1

13

High-throughput

0.618

High

1304820

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.618

High

1304834

TBX21
T-box transcription factor TBX21

1

14

High-throughput

0.618

High

798988

GATA4
Transcription factor GATA-4

2

6

Small-scale

0.584

High

847064

SMCA4
Transcription activator BRG1

2

14

Small-scale

0.584

High

275351

ZMY10
Zinc finger MYND domain-containing protein 10

2

0

High-throughput

0.580

High

183151

KDM6A
Lysine-specific demethylase 6A

1

3

Small-scale

0.552

High

1253595

FBX25
F-box only protein 25

1

2

Small-scale

0.501

High

808874

YAP1
Transcriptional coactivator YAP1

1

2

Small-scale

0.500

High

1273455

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.480

High

129986

MEIS1
Homeobox protein Meis1

1

12

High-throughput

0.479

High

154519

MEIS2
Homeobox protein Meis2

1

14

High-throughput

0.479

High

229474

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

14

High-throughput

0.479

High

232459

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

243568

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

296114

MTA2
Metastasis-associated protein MTA2

1

13

High-throughput

0.479

High

300245

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.479

High

310771

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.479

High

387372

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

428382

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

504628

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

563663

ZNF24
Zinc finger protein 24

1

3

High-throughput

0.479

High

564161

HSP76
Heat shock 70 kDa protein 6

1

2

High-throughput

0.479

High

631560

BRD2
Bromodomain-containing protein 2

1

9

High-throughput

0.479

High

638182

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.479

High

656762

PSB5
Proteasome subunit beta type-5

1

2

High-throughput

0.479

High

658723

SMCA1
Probable global transcription activator SNF2L1

1

14

High-throughput

0.479

High

672882

CDC27
Cell division cycle protein 27 homolog

1

2

High-throughput

0.479

High

682950

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

3

High-throughput

0.479

High

740242

NUP62
Nuclear pore glycoprotein p62

1

8

High-throughput

0.479

High

773089

PBX1
Pre-B-cell leukemia transcription factor 1

1

12

High-throughput

0.479

High

773138

PBX2
Pre-B-cell leukemia transcription factor 2

1

13

High-throughput

0.479

High

773203

PBX3
Pre-B-cell leukemia transcription factor 3

1

15

High-throughput

0.479

High

786095

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

787003

MTREX
Exosome RNA helicase MTR4

1

4

High-throughput

0.479

High

848277

HCFC1
Host cell factor 1

1

1

High-throughput

0.479

High

853048

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.479

High

853438

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.479

High

855185

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

2

High-throughput

0.479

High

858039

NUP98
Nuclear pore complex protein Nup98-Nup96

1

4

High-throughput

0.479

High

861906

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

878146

PKNX1
Homeobox protein PKNOX1

1

13

High-throughput

0.479

High

880273

MAZ
Myc-associated zinc finger protein

1

2

High-throughput

0.479

High

912099

RUXG
Small nuclear ribonucleoprotein G

1

1

High-throughput

0.479

High

917803

H4
Histone H4

1

2

High-throughput

0.479

High

933941

TBB4B
Tubulin beta-4B chain

1

1

High-throughput

0.479

High

943890

RAE1L
mRNA export factor RAE1

1

5

High-throughput

0.479

High

967383

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

986977

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.479

High

987460

MTG8
Protein CBFA2T1

1

1

High-throughput

0.479

High

1017341

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

1029784

TIF1B
Transcription intermediary factor 1-beta

1

6

High-throughput

0.479

High

1049438

MORC3
MORC family CW-type zinc finger protein 3

1

2

High-throughput

0.479

High

1051251

ZMYM3
Zinc finger MYM-type protein 3

1

5

High-throughput

0.479

High

1057606

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

4

High-throughput

0.479

High

1059820

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

7

High-throughput

0.479

High

1071978

PCBP1
Poly(rC)-binding protein 1

1

2

High-throughput

0.479

High

1072164

PCBP2
Poly(rC)-binding protein 2

1

2

High-throughput

0.479

High

1076193

MED1
Mediator of RNA polymerase II transcription subunit 1

1

6

High-throughput

0.479

High

1108875

MA7D1
MAP7 domain-containing protein 1

1

7

High-throughput

0.479

High

1137900

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

2

High-throughput

0.479

High

1139736

ZMYM4
Zinc finger MYM-type protein 4

1

5

High-throughput

0.479

High

1198053

KAISO
Transcriptional regulator Kaiso

1

4

High-throughput

0.479

High

1205804

P66A
Transcriptional repressor p66-alpha

1

3

High-throughput

0.479

High

1218564

MA7D3
MAP7 domain-containing protein 3

1

2

High-throughput

0.479

High

1220145

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

2

High-throughput

0.479

High

1220879

PHC2
Polyhomeotic-like protein 2

1

3

High-throughput

0.479

High

1246154

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.479

High

1251608

SMRC2
SWI/SNF complex subunit SMARCC2

1

14

High-throughput

0.479

High

1263962

P66B
Transcriptional repressor p66-beta

1

3

High-throughput

0.479

High

1272744

GATA6
Transcription factor GATA-6

1

6

High-throughput

0.479

High

1290475

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

1299328

RBM14
RNA-binding protein 14

1

2

High-throughput

0.479

High

1300204

KI20B
Kinesin-like protein KIF20B

1

4

High-throughput

0.479

High

1302690

RBM15
RNA-binding protein 15

1

3

High-throughput

0.479

High

1303685

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.479

High

1304062

RING2
E3 ubiquitin-protein ligase RING2

1

12

High-throughput

0.479

High

1304813

ARI3A
AT-rich interactive domain-containing protein 3A

1

9

High-throughput

0.479

High

1304814

LIMD2
LIM domain-containing protein 2

1

3

High-throughput

0.479

High

1304817

CHM4A
Charged multivesicular body protein 4a

1

3

High-throughput

0.479

High

1304821

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1304825

ING3
Inhibitor of growth protein 3

1

2

High-throughput

0.479

High

1304826

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

11

High-throughput

0.479

High

1304830

ZMYM2
Zinc finger MYM-type protein 2

1

5

High-throughput

0.479

High

1304831

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

16

High-throughput

0.479

High

1304832

APC7
Anaphase-promoting complex subunit 7

1

2

High-throughput

0.479

High

1304833

RCOR1
REST corepressor 1

1

17

High-throughput

0.479

High

1304835

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.479

High

1304837

SCML2
Sex comb on midleg-like protein 2

1

5

High-throughput

0.479

High

1304842

SALL2
Sal-like protein 2

1

4

High-throughput

0.479

High

1304843

MTF2
Metal-response element-binding transcription factor 2

1

2

High-throughput

0.479

High

121841

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

0

High-throughput

0.458

High

130267

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.458

High

198699

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.458

High

397483

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.458

High

453894

RU2A
U2 small nuclear ribonucleoprotein A'

1

0

High-throughput

0.458

High

571566

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.458

High

601343

VDAC1
Voltage-dependent anion-selective channel protein 1

1

0

High-throughput

0.458

High

613007

TCEA1
Transcription elongation factor A protein 1

1

0

High-throughput

0.458

High

722633

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.458

High

834829

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.458

High

844208

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.458

High

848943

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

854350

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

907133

PRS8
26S proteasome regulatory subunit 8

1

0

High-throughput

0.458

High

910739

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.458

High

911485

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.458

High

911725

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.458

High

985685

CTSL2
CTD small phosphatase-like protein 2

1

0

High-throughput

0.458

High

1064630

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1078341

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1203670

AROS
Active regulator of SIRT1

1

0

High-throughput

0.458

High

1216250

H2A2B
Histone H2A type 2-B

1

0

High-throughput

0.458

High

1242538

RCBT1
RCC1 and BTB domain-containing protein 1

1

0

High-throughput

0.458

High

1244672

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1252112

PUM2
Pumilio homolog 2

1

0

High-throughput

0.458

High

1300432

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1302432

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.458

High

1304550

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

1304816

REPI1
Replication initiator 1

1

0

High-throughput

0.458

High

1304818

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.458

High

1304819

OSBL8
Oxysterol-binding protein-related protein 8

1

0

High-throughput

0.458

High

1304822

MSL2
E3 ubiquitin-protein ligase MSL2

1

0

High-throughput

0.458

High

1304823

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.458

High

1304824

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.458

High

1304829

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.458

High

1304838

RTRAF
RNA transcription, translation and transport factor protein

1

0

High-throughput

0.458

High

1304839

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

0

High-throughput

0.458

High

1304840

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.458

High

1304841

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.458

High

1304844

MB212
Protein mab-21-like 2

1

0

High-throughput

0.458

High

717301

CTNB1
Catenin beta-1

1

4

Small-scale

0.445

High

149209

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.437

High

637031

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

1024081

ACACA
Acetyl-CoA carboxylase 1

1

2

High-throughput

0.437

High

1135301

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.437

High

1135789

UT14C
U3 small nucleolar RNA-associated protein 14 homolog C

1

2

High-throughput

0.437

High

1163027

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

3

High-throughput

0.437

High

1291668

CHMP6
Charged multivesicular body protein 6

1

3

High-throughput

0.437

High

1304815

NUP58
Nucleoporin p58/p45

1

1

High-throughput

0.437

High

1304827

CHMP5
Charged multivesicular body protein 5

1

3

High-throughput

0.437

High

1304828

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.437

High

687271

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

0

High-throughput

0.249

Low

1234206

MPND
MPN domain-containing protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024