Protein: CCND2
G1/S-specific cyclin-D2

Gene: CCND2
Organism: Homo sapiens
Interactions: 143
UniProt ID: P30279

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0000785 - chromatin
GO:0001934 - positive regulation of protein phosphorylation
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

515347

CDK4
Cyclin-dependent kinase 4

18

20

Small-scale

0.987

High

673031

CDN1A
Cyclin-dependent kinase inhibitor 1

17

20

Small-scale

0.987

High

673063

CDK5
Cyclin-dependent kinase 5

12

20

Small-scale

0.985

High

673062

CDK6
Cyclin-dependent kinase 6

7

20

Small-scale

0.962

High

673038

CDN1B
Cyclin-dependent kinase inhibitor 1B

6

20

Small-scale

0.952

High

625155

CDK2
Cyclin-dependent kinase 2

6

20

Small-scale

0.942

High

673041

CDN1C
Cyclin-dependent kinase inhibitor 1C

3

20

High-throughput

0.861

High

414764

CDK1
Cyclin-dependent kinase 1

1

20

High-throughput

0.691

High

414187

RB
Retinoblastoma-associated protein

4

18

Small-scale

0.688

High

673066

RBL2
Retinoblastoma-like protein 2

3

18

High-throughput

0.667

High

673097

Q96TE0
Cyclin-dependent kinase inhibitor 1B

1

20

Small-scale

0.665

High

673034

CDN2A
Cyclin-dependent kinase inhibitor 2A

3

8

Small-scale

0.655

High

160402

AURKA
Aurora kinase A

1

7

High-throughput

0.647

High

373752

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.647

High

624547

CCNE1
G1/S-specific cyclin-E1

1

5

High-throughput

0.647

High

673022

CCND2
G1/S-specific cyclin-D2

1

6

High-throughput

0.647

High

673024

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

High-throughput

0.647

High

673039

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

19

High-throughput

0.647

High

673044

CDK7
Cyclin-dependent kinase 7

1

20

Small-scale

0.647

High

673045

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

19

High-throughput

0.647

High

673082

MK14
Mitogen-activated protein kinase 14

1

20

High-throughput

0.647

High

673099

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

5

High-throughput

0.647

High

673106

LATS2
Serine/threonine-protein kinase LATS2

1

5

High-throughput

0.647

High

673079

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.614

High

673064

H11
Histone H1.1

2

9

Small-scale

0.602

High

673027

PCGF2
Polycomb group RING finger protein 2

1

2

Small-scale

0.589

High

673068

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

9

High-throughput

0.579

High

673112

FBXL2
F-box/LRR-repeat protein 2

1

8

Small-scale

0.561

High

673073

DMP1
Dentin matrix acidic phosphoprotein 1

1

0

Small-scale

0.537

High

517080

PCNA
Proliferating cell nuclear antigen

1

5

High-throughput

0.536

High

673043

PEX5
Peroxisomal targeting signal 1 receptor

1

6

High-throughput

0.536

High

673086

CYTSA
Cytospin-A

1

1

High-throughput

0.536

High

673089

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

673096

NEB2
Neurabin-2

1

2

High-throughput

0.536

High

428930

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

276144

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

Small-scale

0.501

High

337364

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.501

High

383638

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

4

High-throughput

0.501

High

488585

ARAF
Serine/threonine-protein kinase A-Raf

1

4

High-throughput

0.501

High

557043

PGFRA
Platelet-derived growth factor receptor alpha

1

3

High-throughput

0.501

High

607892

FGFR4
Fibroblast growth factor receptor 4

1

3

High-throughput

0.501

High

649040

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.501

High

673033

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

High-throughput

0.501

High

673035

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

8

High-throughput

0.501

High

673036

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

9

High-throughput

0.501

High

673050

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.501

High

673065

TF65
Transcription factor p65

1

4

High-throughput

0.501

High

673083

HIF1A
Hypoxia-inducible factor 1-alpha

1

4

High-throughput

0.501

High

673092

TSC1
Hamartin

1

2

High-throughput

0.501

High

673093

KAT2A
Histone acetyltransferase KAT2A

1

12

High-throughput

0.501

High

673102

GLIS2
Zinc finger protein GLIS2

1

3

High-throughput

0.501

High

673107

RASF1
Ras association domain-containing protein 1

1

1

High-throughput

0.501

High

673115

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.501

High

673090

TEX11
Testis-expressed protein 11

1

1

High-throughput

0.481

High

153995

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

536121

HGF
Hepatocyte growth factor

1

0

High-throughput

0.480

High

555082

CD44
CD44 antigen

1

0

High-throughput

0.480

High

673028

MERL
Merlin

1

0

High-throughput

0.480

High

673070

GRM1
Metabotropic glutamate receptor 1

1

0

High-throughput

0.480

High

673076

BECN1
Beclin-1

1

0

High-throughput

0.480

High

673078

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.480

High

673110

SRTD1
SERTA domain-containing protein 1

1

0

Small-scale

0.480

High

124578

CLIC1
Chloride intracellular channel protein 1

1

1

Small-scale

0.479

High

124774

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

8

Small-scale

0.479

High

198556

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

213487

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

7

Small-scale

0.479

High

215589

AKAP8
A-kinase anchor protein 8

1

4

Small-scale

0.479

High

226621

PRKN
E3 ubiquitin-protein ligase parkin

1

7

Small-scale

0.479

High

388253

HSPB1
Heat shock protein beta-1

1

6

Small-scale

0.479

High

413838

GELS
Gelsolin

1

3

Small-scale

0.479

High

572869

PRS6A
26S proteasome regulatory subunit 6A

1

6

Small-scale

0.479

High

607006

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.479

High

637781

PSA3
Proteasome subunit alpha type-3

1

3

Small-scale

0.479

High

650453

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

Small-scale

0.479

High

673023

DNJA1
DnaJ homolog subfamily A member 1

1

3

Small-scale

0.479

High

673026

HS71L
Heat shock 70 kDa protein 1-like

1

4

Small-scale

0.479

High

673029

RFA3
Replication protein A 14 kDa subunit

1

3

Small-scale

0.479

High

673030

PRS7
26S proteasome regulatory subunit 7

1

4

Small-scale

0.479

High

673032

STA5A
Signal transducer and activator of transcription 5A

1

5

Small-scale

0.479

High

673037

PRS6B
26S proteasome regulatory subunit 6B

1

4

Small-scale

0.479

High

673040

TSC2
Tuberin

1

5

Small-scale

0.479

High

673042

F10A1
Hsc70-interacting protein

1

4

Small-scale

0.479

High

673046

XPO2
Exportin-2

1

2

Small-scale

0.479

High

673048

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

5

Small-scale

0.479

High

673051

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

673052

PRS4
26S proteasome regulatory subunit 4

1

4

Small-scale

0.479

High

673053

PRS8
26S proteasome regulatory subunit 8

1

6

Small-scale

0.479

High

673056

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

Small-scale

0.479

High

673059

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

15

Small-scale

0.479

High

673060

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.479

High

673061

TBB4B
Tubulin beta-4B chain

1

2

Small-scale

0.479

High

673067

FLII
Protein flightless-1 homolog

1

4

Small-scale

0.479

High

673071

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.479

High

673072

SKP2
S-phase kinase-associated protein 2

1

8

Small-scale

0.479

High

673074

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

9

Small-scale

0.479

High

673085

ACTBL
Beta-actin-like protein 2

1

1

Small-scale

0.479

High

673087

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

673088

H2AV
Histone H2A.V

1

1

Small-scale

0.479

High

673091

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

1

Small-scale

0.479

High

673094

DTBP1
Dysbindin

1

3

Small-scale

0.479

High

673101

TBB6
Tubulin beta-6 chain

1

2

Small-scale

0.479

High

673104

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

6

Small-scale

0.479

High

673108

TBA8
Tubulin alpha-8 chain

1

2

Small-scale

0.479

High

673116

STRAP
Serine-threonine kinase receptor-associated protein

1

11

Small-scale

0.479

High

673117

TLN2
Talin-2

1

1

Small-scale

0.479

High

673118

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

1

Small-scale

0.479

High

121947

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

149557

COPE
Coatomer subunit epsilon

1

0

Small-scale

0.458

High

210888

GET3
ATPase GET3

1

0

Small-scale

0.458

High

259243

ZPR1
Zinc finger protein ZPR1

1

0

Small-scale

0.458

High

391564

H2A1B
Histone H2A type 1-B/E

1

0

Small-scale

0.458

High

415219

ATPB
ATP synthase subunit beta, mitochondrial

1

0

Small-scale

0.458

High

416579

S10A6
Protein S100-A6

1

0

Small-scale

0.458

High

445290

RSSA
Small ribosomal subunit protein uS2

1

0

Small-scale

0.458

High

624339

MYL9
Myosin regulatory light polypeptide 9

1

0

Small-scale

0.458

High

656560

PSB6
Proteasome subunit beta type-6

1

0

Small-scale

0.458

High

673047

PSA
Puromycin-sensitive aminopeptidase

1

0

Small-scale

0.458

High

673049

IF6
Eukaryotic translation initiation factor 6

1

0

Small-scale

0.458

High

673054

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

Small-scale

0.458

High

673055

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.458

High

673057

DYLT1
Dynein light chain Tctex-type 1

1

0

Small-scale

0.458

High

673058

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

Small-scale

0.458

High

673069

CBX3
Chromobox protein homolog 3

1

0

Small-scale

0.458

High

673075

DCTN2
Dynactin subunit 2

1

0

Small-scale

0.458

High

673077

PLEC
Plectin

1

0

Small-scale

0.458

High

673080

SEPT7
Septin-7

1

0

Small-scale

0.458

High

673081

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

Small-scale

0.458

High

673095

NUDC1
NudC domain-containing protein 1

1

0

Small-scale

0.458

High

673098

PFD5
Prefoldin subunit 5

1

0

Small-scale

0.458

High

673103

API5
Apoptosis inhibitor 5

1

0

Small-scale

0.458

High

673111

PFD2
Prefoldin subunit 2

1

0

Small-scale

0.458

High

673113

PSME2
Proteasome activator complex subunit 2

1

0

Small-scale

0.458

High

441443

MET
Hepatocyte growth factor receptor

1

1

High-throughput

0.457

High

584326

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.457

High

673105

NPDC1
Neural proliferation differentiation and control protein 1

1

2

Small-scale

0.457

High

665149

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.261

Low

673025

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.261

Low

673084

ABCB5
ATP-binding cassette sub-family B member 5

1

0

High-throughput

0.261

Low

673100

TTYH2
Protein tweety homolog 2

1

0

High-throughput

0.261

Low

673114

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.261

Low

237030

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

Small-scale

0.249

Low

673109

TMOD3
Tropomodulin-3

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024