Protein: TOP2
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)

Gene: TOP2
Organism: Drosophila melanogaster
Interactions: 34
UniProt ID: P15348

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000182 - rDNA binding
GO:0000278 - mitotic cell cycle
GO:0000400 - four-way junction DNA binding
GO:0000712 - resolution of meiotic recombination intermediates

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

547870

TOP2
DNA topoisomerase 2

1

16

Small-scale

0.647

High

547872

MLE
Dosage compensation regulator mle

1

3

Small-scale

0.618

High

547895

Q9VY97
Mutagen-sensitive 101

1

3

Small-scale

0.561

High

547874

PHP
Polyhomeotic-proximal chromatin protein

2

3

Small-scale

0.552

High

547884

MMD4
Modifier of mdg4

1

2

Small-scale

0.552

High

332732

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

9

Small-scale

0.479

High

547875

MSL3
Protein male-specific lethal-3

1

1

Small-scale

0.479

High

547879

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

11

Small-scale

0.479

High

547886

Q9NF31
EG:BACN25G24.3 protein

1

2

Small-scale

0.479

High

547889

Q9VIP9
Condensin complex subunit 2

1

2

Small-scale

0.479

High

547896

Q9VYB1
Kinetochore protein NDC80

1

3

Small-scale

0.479

High

547877

Q0E8J0
MEP-1, isoform A

1

0

Small-scale

0.458

High

547881

Q6NQZ7
LD40663p

1

0

High-throughput

0.458

High

547887

DPOE3
DNA polymerase epsilon subunit 3

1

0

Small-scale

0.458

High

2406

NOVA
RNA-binding protein Pasilla

1

2

High-throughput

0.445

High

114937

M9PE01
Ecdysone-induced protein 63E, isoform N

1

2

High-throughput

0.445

High

547871

SGG
Protein kinase shaggy

1

1

High-throughput

0.445

High

547873

GPRK2
G protein-coupled receptor kinase 2

1

6

High-throughput

0.445

High

547882

Q6QU65
ADAM metalloprotease

1

1

High-throughput

0.445

High

547890

Q9VMT1
receptor protein serine/threonine kinase

1

1

High-throughput

0.445

High

547891

COLD
UPAR/Ly6 domain-containing protein cold

1

1

High-throughput

0.445

High

547893

AGO2
Protein argonaute-2

1

1

High-throughput

0.445

High

547885

Q8IRH7
Supercoiling factor variant B

1

2

Small-scale

0.437

High

547878

Q0KHS0
Katanin p80 WD40 repeat-containing subunit B1

1

8

High-throughput

0.407

High

397188

KPC1
Protein kinase C, brain isozyme

1

6

High-throughput

0.381

High

437055

CSK2A
Casein kinase II subunit alpha

1

3

High-throughput

0.381

High

547876

P91663
Condensin complex subunit 2

1

2

High-throughput

0.381

High

116172

M9PHX2
Visgun, isoform E

1

0

High-throughput

0.253

Low

547883

IMD
Protein immune deficiency

1

0

High-throughput

0.249

Low

547888

Q9VHP9
Centromeric protein-C, isoform A

1

0

Small-scale

0.249

Low

547894

PGPLE
Peptidoglycan-recognition protein LE

1

0

High-throughput

0.249

Low

547880

MOX12
MOXD1 homolog 2

1

0

High-throughput

0.232

Low

547892

Q9VPX2
Major facilitator superfamily transporter 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024