Protein: ERCC6
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)

Gene: ERCC6
Organism: Homo sapiens
Interactions: 223
UniProt ID: Q03468

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000077 - DNA damage checkpoint signaling
GO:0000303 - response to superoxide
GO:0003677 - DNA binding
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391663

H2A1B
Histone H2A type 1-B/E

2

20

Small-scale

0.819

High

962021

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

18

Small-scale

0.789

High

976442

ERCC8
DNA excision repair protein ERCC-8

13

20

Small-scale

0.760

High

676865

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

5

Small-scale

0.754

High

707597

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.724

High

917147

H4
Histone H4

1

17

Small-scale

0.724

High

934683

H31
Histone H3.1

1

20

Small-scale

0.724

High

624871

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

12

Small-scale

0.719

High

976500

MPP8
M-phase phosphoprotein 8

1

5

High-throughput

0.691

High

976494

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

9

Small-scale

0.670

High

386571

P53
Cellular tumor antigen p53

3

9

Small-scale

0.667

High

757577

IF4A3
Eukaryotic initiation factor 4A-III

1

19

High-throughput

0.647

High

896727

ARP3
Actin-related protein 3

1

19

High-throughput

0.647

High

896874

ARP2
Actin-related protein 2

1

17

High-throughput

0.647

High

976436

ERCC6
DNA excision repair protein ERCC-6

1

18

High-throughput

0.647

High

976462

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

16

High-throughput

0.647

High

659920

ERCC5
DNA excision repair protein ERCC-5

3

1

Small-scale

0.646

High

976441

RBBP4
Histone-binding protein RBBP4

3

20

Small-scale

0.646

High

976446

HDAC1
Histone deacetylase 1

3

20

Small-scale

0.646

High

976459

DDB1
DNA damage-binding protein 1

3

6

Small-scale

0.640

High

455344

PARP1
Poly [ADP-ribose] polymerase 1

2

20

Small-scale

0.634

High

749401

BRCA1
Breast cancer type 1 susceptibility protein

2

13

Small-scale

0.624

High

649471

RL10
Large ribosomal subunit protein uL16

2

4

High-throughput

0.619

High

133989

DDX3X
ATP-dependent RNA helicase DDX3X

1

15

Small-scale

0.618

High

229372

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

17

Small-scale

0.618

High

316016

CBX6
Chromobox protein homolog 6

1

20

High-throughput

0.618

High

571411

DDX5
Probable ATP-dependent RNA helicase DDX5

1

15

Small-scale

0.618

High

583465

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

7

Small-scale

0.618

High

584586

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

17

Small-scale

0.618

High

658654

SMCA1
Probable global transcription activator SNF2L1

1

17

Small-scale

0.618

High

828204

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.618

High

846754

SMCA2
Probable global transcription activator SNF2L2

1

18

Small-scale

0.618

High

846939

SMCA4
Transcription activator BRG1

1

18

Small-scale

0.618

High

952286

H33
Histone H3.3

1

20

High-throughput

0.618

High

976452

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

15

Small-scale

0.618

High

976461

H2A2C
Histone H2A type 2-C

1

20

Small-scale

0.618

High

976467

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

Small-scale

0.618

High

976486

DDX1
ATP-dependent RNA helicase DDX1

1

19

Small-scale

0.618

High

976491

DDX17
Probable ATP-dependent RNA helicase DDX17

1

15

Small-scale

0.618

High

976506

DDX23
Probable ATP-dependent RNA helicase DDX23

1

19

Small-scale

0.618

High

976512

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

14

Small-scale

0.618

High

976519

HELLS
Lymphoid-specific helicase

1

19

Small-scale

0.618

High

976526

DDX41
Probable ATP-dependent RNA helicase DDX41

1

17

Small-scale

0.618

High

337435

ABL1
Tyrosine-protein kinase ABL1

1

7

Small-scale

0.598

High

295993

MTA2
Metastasis-associated protein MTA2

2

20

Small-scale

0.595

High

517207

PCNA
Proliferating cell nuclear antigen

2

2

Small-scale

0.595

High

524888

XRCC5
X-ray repair cross-complementing protein 5

2

9

Small-scale

0.595

High

854295

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

1

Small-scale

0.595

High

906998

PRS8
26S proteasome regulatory subunit 8

2

3

Small-scale

0.595

High

976455

NONO
Non-POU domain-containing octamer-binding protein

2

20

Small-scale

0.595

High

976485

P66B
Transcriptional repressor p66-beta

2

15

Small-scale

0.595

High

317103

RPA1
DNA-directed RNA polymerase I subunit RPA1

2

12

Small-scale

0.584

High

874844

TERA
Transitional endoplasmic reticulum ATPase

2

2

Small-scale

0.584

High

976447

CUL4A
Cullin-4A

2

12

Small-scale

0.584

High

976473

CSN6
COP9 signalosome complex subunit 6

2

4

Small-scale

0.584

High

976475

CAND1
Cullin-associated NEDD8-dissociated protein 1

2

6

Small-scale

0.584

High

976504

CSN4
COP9 signalosome complex subunit 4

2

1

Small-scale

0.584

High

976530

CSN3
COP9 signalosome complex subunit 3

2

3

Small-scale

0.584

High

123241

CBX4
E3 SUMO-protein ligase CBX4

1

20

High-throughput

0.575

High

612474

XPA
DNA repair protein complementing XP-A cells

2

0

Small-scale

0.569

High

976463

UVSSA
UV-stimulated scaffold protein A

2

0

Small-scale

0.559

High

133453

NOP56
Nucleolar protein 56

1

7

High-throughput

0.536

High

851464

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.536

High

976440

BAX
Apoptosis regulator BAX

1

1

High-throughput

0.536

High

976516

SYF1
Pre-mRNA-splicing factor SYF1

1

13

Small-scale

0.536

High

976469

DCR1A
DNA cross-link repair 1A protein

1

0

Small-scale

0.529

High

212131

HTSF1
17S U2 SnRNP complex component HTATSF1

1

20

High-throughput

0.501

High

328530

MBD3
Methyl-CpG-binding domain protein 3

1

20

High-throughput

0.501

High

475648

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

Small-scale

0.501

High

501998

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.501

High

518858

TPR
Nucleoprotein TPR

1

20

High-throughput

0.501

High

548239

FOSL1
Fos-related antigen 1

1

8

High-throughput

0.501

High

578421

RCC1
Regulator of chromosome condensation

1

2

High-throughput

0.501

High

586696

CSK22
Casein kinase II subunit alpha'

1

11

High-throughput

0.501

High

642307

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.501

High

668613

PML
Protein PML

1

16

High-throughput

0.501

High

751587

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.501

High

770797

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.501

High

805968

RL5
Large ribosomal subunit protein uL18

1

5

High-throughput

0.501

High

815978

ATPO
ATP synthase subunit O, mitochondrial

1

2

High-throughput

0.501

High

821175

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.501

High

843619

FXR1
RNA-binding protein FXR1

1

14

High-throughput

0.501

High

847147

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

1

High-throughput

0.501

High

876765

NP1L1
Nucleosome assembly protein 1-like 1

1

3

High-throughput

0.501

High

902539

SUMO2
Small ubiquitin-related modifier 2

1

17

High-throughput

0.501

High

907647

RS15A
Small ribosomal subunit protein uS8

1

7

High-throughput

0.501

High

912273

SMD1
Small nuclear ribonucleoprotein Sm D1

1

4

High-throughput

0.501

High

916535

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.501

High

919945

RS15
Small ribosomal subunit protein uS19

1

5

High-throughput

0.501

High

920155

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.501

High

921824

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.501

High

923649

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.501

High

928070

SUMO1
Small ubiquitin-related modifier 1

1

17

High-throughput

0.501

High

930157

UBC9
SUMO-conjugating enzyme UBC9

1

7

High-throughput

0.501

High

931597

CSK2B
Casein kinase II subunit beta

1

5

High-throughput

0.501

High

942143

GTF2I
General transcription factor II-I

1

1

High-throughput

0.501

High

976443

MTA1
Metastasis-associated protein MTA1

1

20

High-throughput

0.501

High

976449

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.501

High

976451

ELOA1
Elongin-A

1

11

Small-scale

0.501

High

976456

SF3B3
Splicing factor 3B subunit 3

1

6

High-throughput

0.501

High

976460

RBBP7
Histone-binding protein RBBP7

1

20

High-throughput

0.501

High

976472

SPT6H
Transcription elongation factor SPT6

1

9

High-throughput

0.501

High

976479

PAF1
RNA polymerase II-associated factor 1 homolog

1

6

High-throughput

0.501

High

976484

LEO1
RNA polymerase-associated protein LEO1

1

7

High-throughput

0.501

High

976488

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

11

High-throughput

0.501

High

976489

HDAC2
Histone deacetylase 2

1

20

High-throughput

0.501

High

976495

CUL5
Cullin-5

1

12

Small-scale

0.501

High

976498

IWS1
Protein IWS1 homolog

1

8

High-throughput

0.501

High

976505

MTA3
Metastasis-associated protein MTA3

1

20

High-throughput

0.501

High

976515

SENP2
Sentrin-specific protease 2

1

4

High-throughput

0.501

High

976520

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

3

High-throughput

0.501

High

976522

SAE1
SUMO-activating enzyme subunit 1

1

1

High-throughput

0.501

High

976523

SAE2
SUMO-activating enzyme subunit 2

1

2

High-throughput

0.501

High

976531

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

2

High-throughput

0.501

High

976471

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.493

High

976533

RNF11
RING finger protein 11

1

0

High-throughput

0.486

High

149617

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.480

High

541349

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.480

High

677941

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.480

High

714957

PROF2
Profilin-2

1

0

High-throughput

0.480

High

911000

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.480

High

976450

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.480

High

976466

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.480

High

976480

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

High-throughput

0.480

High

976482

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.480

High

976487

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.480

High

976497

UIF
UAP56-interacting factor

1

0

High-throughput

0.480

High

976510

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.480

High

976513

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.480

High

976534

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.480

High

976535

CLIC4
Chloride intracellular channel protein 4

1

0

High-throughput

0.480

High

121994

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

Small-scale

0.479

High

122683

MEN1
Menin

1

4

High-throughput

0.479

High

146809

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

10

High-throughput

0.479

High

181412

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

Small-scale

0.479

High

181954

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

1

Small-scale

0.479

High

197005

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

17

Small-scale

0.479

High

198607

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

Small-scale

0.479

High

202423

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

2

Small-scale

0.479

High

268687

SF3B1
Splicing factor 3B subunit 1

1

4

Small-scale

0.479

High

318607

EYA4
Eyes absent homolog 4

1

16

Small-scale

0.479

High

346581

MYC
Myc proto-oncogene protein

1

20

High-throughput

0.479

High

369451

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

508468

TOP1
DNA topoisomerase 1

1

9

Small-scale

0.479

High

508954

TOP2A
DNA topoisomerase 2-alpha

1

13

Small-scale

0.479

High

574143

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.479

High

579196

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

13

Small-scale

0.479

High

582240

NUCL
Nucleolin

1

13

Small-scale

0.479

High

583694

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

Small-scale

0.479

High

587540

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

7

High-throughput

0.479

High

600557

EPHA1
Ephrin type-A receptor 1

1

4

High-throughput

0.479

High

613426

SFPQ
Splicing factor, proline- and glutamine-rich

1

19

Small-scale

0.479

High

651009

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

12

Small-scale

0.479

High

658350

DPOD1
DNA polymerase delta catalytic subunit

1

3

Small-scale

0.479

High

745131

RBMX
RNA-binding motif protein, X chromosome

1

11

Small-scale

0.479

High

836995

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.479

High

838781

EMD
Emerin

1

1

Small-scale

0.479

High

913893

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

Small-scale

0.479

High

962740

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.479

High

973315

TOP2B
DNA topoisomerase 2-beta

1

14

Small-scale

0.479

High

976438

CSTF1
Cleavage stimulation factor subunit 1

1

17

Small-scale

0.479

High

976439

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

Small-scale

0.479

High

976445

SF3B2
Splicing factor 3B subunit 2

1

2

Small-scale

0.479

High

976448

CUL4B
Cullin-4B

1

12

Small-scale

0.479

High

976454

TEBP
Prostaglandin E synthase 3

1

5

High-throughput

0.479

High

976458

E2F4
Transcription factor E2F4

1

6

High-throughput

0.479

High

976465

RIF1
Telomere-associated protein RIF1

1

6

Small-scale

0.479

High

976468

CTR9
RNA polymerase-associated protein CTR9 homolog

1

11

Small-scale

0.479

High

976476

P66A
Transcriptional repressor p66-alpha

1

15

Small-scale

0.479

High

976477

SLX4
Structure-specific endonuclease subunit SLX4

1

16

High-throughput

0.479

High

976481

FBX22
F-box only protein 22

1

4

High-throughput

0.479

High

976483

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

976490

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.479

High

976492

RAD50
DNA repair protein RAD50

1

18

Small-scale

0.479

High

976511

CRNL1
Crooked neck-like protein 1

1

15

Small-scale

0.479

High

976514

SP110
Sp110 nuclear body protein

1

18

High-throughput

0.479

High

976518

ANLN
Anillin

1

4

High-throughput

0.479

High

976524

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

976525

BAZ1B
Tyrosine-protein kinase BAZ1B

1

20

Small-scale

0.479

High

976527

PNMA2
Paraneoplastic antigen Ma2

1

6

High-throughput

0.479

High

246213

NBN
Nibrin

1

0

Small-scale

0.458

High

396921

HMGN1
Non-histone chromosomal protein HMG-14

1

0

Small-scale

0.458

High

656702

PSB5
Proteasome subunit beta type-5

1

0

Small-scale

0.458

High

976437

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

Small-scale

0.458

High

976493

XPF
DNA repair endonuclease XPF

1

0

Small-scale

0.458

High

976499

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.458

High

976502

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.458

High

124841

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

6

High-throughput

0.457

High

176767

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

3

High-throughput

0.457

High

446377

RM03
Large ribosomal subunit protein uL3m

1

4

High-throughput

0.457

High

671432

ECHM
Enoyl-CoA hydratase, mitochondrial

1

4

High-throughput

0.457

High

682333

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

2

High-throughput

0.457

High

735927

ATPG
ATP synthase subunit gamma, mitochondrial

1

2

High-throughput

0.457

High

957264

FBLN2
Fibulin-2

1

6

High-throughput

0.457

High

976444

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

14

High-throughput

0.457

High

976464

FND3B
Fibronectin type III domain-containing protein 3B

1

3

High-throughput

0.457

High

976501

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

2

High-throughput

0.457

High

976508

RM13
Large ribosomal subunit protein uL13m

1

3

High-throughput

0.457

High

976529

COR1C
Coronin-1C

1

20

High-throughput

0.457

High

717735

BMI1
Polycomb complex protein BMI-1

1

13

High-throughput

0.445

High

360639

SPTA1
Spectrin alpha chain, erythrocytic 1

1

4

Small-scale

0.437

High

771147

TPOR
Thrombopoietin receptor

1

1

High-throughput

0.437

High

976453

CUL7
Cullin-7

1

2

Small-scale

0.437

High

976521

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

976528

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.437

High

976457

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.279

Low

159479

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.261

Low

431210

CATB
Cathepsin B

1

0

High-throughput

0.261

Low

922054

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.261

Low

946854

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.261

Low

947040

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.261

Low

950940

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.261

Low

976474

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.261

Low

976478

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.261

Low

976496

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.261

Low

976503

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.261

Low

976507

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.261

Low

976509

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.261

Low

976517

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.261

Low

976532

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.261

Low

612003

HEMH
Ferrochelatase, mitochondrial

1

0

Small-scale

0.249

Low

976470

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024