Protein: SPF27
Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)

Gene: SPF27, BCAS2
Organism: Homo sapiens
Interactions: 240
UniProt ID: O75934

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

278565

PRP19
Pre-mRNA-processing factor 19

9

8

Small-scale

0.979

High

278517

CDC5L
Cell division cycle 5-like protein

9

3

Small-scale

0.978

High

209365

PLRG1
Pleiotropic regulator 1

5

5

Small-scale

0.727

High

278470

PRP8
Pre-mRNA-processing-splicing factor 8

4

1

High-throughput

0.701

High

278368

MYC
Myc proto-oncogene protein

4

1

High-throughput

0.676

High

278439

SNW1
SNW domain-containing protein 1

3

1

High-throughput

0.669

High

278435

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

4

0

High-throughput

0.668

High

278527

YJU2
Splicing factor YJU2

3

1

High-throughput

0.667

High

278369

ESR1
Estrogen receptor

3

3

Small-scale

0.665

High

278522

USB1
U6 snRNA phosphodiesterase 1

3

0

High-throughput

0.638

High

278533

DSN1
Kinetochore-associated protein DSN1 homolog

3

0

High-throughput

0.638

High

278566

PPIE
Peptidyl-prolyl cis-trans isomerase E

3

0

High-throughput

0.638

High

278379

RU1C
U1 small nuclear ribonucleoprotein C

3

0

High-throughput

0.636

High

278397

RFA1
Replication protein A 70 kDa DNA-binding subunit

3

0

Small-scale

0.636

High

278452

K1H1
Keratin, type I cuticular Ha1

4

7

High-throughput

0.633

High

278391

CSK22
Casein kinase II subunit alpha'

2

1

High-throughput

0.628

High

278529

NDEL1
Nuclear distribution protein nudE-like 1

2

1

High-throughput

0.628

High

278564

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.618

High

271986

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

2

4

Small-scale

0.614

High

278524

WDR83
WD repeat domain-containing protein 83

2

11

High-throughput

0.614

High

278552

RBM22
Pre-mRNA-splicing factor RBM22

2

2

High-throughput

0.614

High

278557

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.614

High

278388

RFA2
Replication protein A 32 kDa subunit

3

0

Small-scale

0.613

High

278450

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

2

High-throughput

0.611

High

278506

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

2

4

High-throughput

0.611

High

278394

RBTN2
Rhombotin-2

2

3

High-throughput

0.606

High

278395

RBTN1
Rhombotin-1

2

3

High-throughput

0.606

High

278492

LMO3
LIM domain only protein 3

2

3

High-throughput

0.606

High

278367

SYF2
Pre-mRNA-splicing factor SYF2

2

0

High-throughput

0.602

High

278501

PRCC
Proline-rich protein PRCC

2

0

High-throughput

0.602

High

278387

ITF2
Transcription factor 4

2

0

High-throughput

0.601

High

278561

IKZF3
Zinc finger protein Aiolos

2

0

High-throughput

0.601

High

278538

LN28A
Protein lin-28 homolog A

2

1

High-throughput

0.601

High

278500

ESR2
Estrogen receptor beta

2

2

Small-scale

0.595

High

278468

K1C40
Keratin, type I cytoskeletal 40

2

7

High-throughput

0.588

High

267599

TADA3
Transcriptional adapter 3

2

0

High-throughput

0.585

High

278575

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

2

0

High-throughput

0.585

High

243721

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

278504

FBXW7
F-box/WD repeat-containing protein 7

2

1

Small-scale

0.584

High

204261

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

252947

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

278362

ZWINT
ZW10 interactor

2

0

High-throughput

0.580

High

278423

IN35
Interferon-induced 35 kDa protein

2

0

High-throughput

0.580

High

278425

PAX5
Paired box protein Pax-5

2

0

High-throughput

0.580

High

278488

SMIP6
Sperm microtubule inner protein 6

2

0

High-throughput

0.580

High

278497

SMIP5
Sperm-associated microtubule inner protein 5

2

0

High-throughput

0.580

High

278508

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

0

High-throughput

0.580

High

278518

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

278520

THIOM
Thioredoxin, mitochondrial

2

0

High-throughput

0.580

High

278525

TCHP
Trichoplein keratin filament-binding protein

2

0

High-throughput

0.580

High

278530

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

278531

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

2

0

High-throughput

0.580

High

278554

MED29
Mediator of RNA polymerase II transcription subunit 29

2

0

High-throughput

0.580

High

278567

PLAL2
Zinc finger protein PLAGL2

2

0

High-throughput

0.580

High

278499

CTBL1
Beta-catenin-like protein 1

2

0

Small-scale

0.576

High

278555

CWC15
Spliceosome-associated protein CWC15 homolog

2

0

Small-scale

0.576

High

159811

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

1

High-throughput

0.573

High

278400

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

278357

KRT34
Keratin, type I cuticular Ha4

2

7

High-throughput

0.553

High

278358

KRT36
Keratin, type I cuticular Ha6

2

7

High-throughput

0.553

High

278359

KRT37
Keratin, type I cuticular Ha7

2

7

High-throughput

0.553

High

278401

K1C20
Keratin, type I cytoskeletal 20

2

6

High-throughput

0.553

High

278414

LMO4
LIM domain transcription factor LMO4

2

3

High-throughput

0.553

High

278475

K1C27
Keratin, type I cytoskeletal 27

2

6

High-throughput

0.553

High

278486

USBP1
Harmonin-binding protein USHBP1

2

2

High-throughput

0.553

High

278502

KRT35
Keratin, type I cuticular Ha5

2

7

High-throughput

0.553

High

278536

PKHF2
Pleckstrin homology domain-containing family F member 2

2

1

High-throughput

0.553

High

278453

SF3B4
Splicing factor 3B subunit 4

1

0

High-throughput

0.549

High

230693

AQR
RNA helicase aquarius

1

1

High-throughput

0.536

High

236179

PRP17
Pre-mRNA-processing factor 17

1

10

High-throughput

0.536

High

268546

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.536

High

278376

RU2B
U2 small nuclear ribonucleoprotein B''

1

2

High-throughput

0.536

High

278378

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

278380

HMGB1
High mobility group protein B1

1

2

High-throughput

0.536

High

278384

YJU2B
Probable splicing factor YJU2B

1

1

High-throughput

0.536

High

278386

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

278392

LMNB1
Lamin-B1

1

3

High-throughput

0.536

High

278404

BUD31
Protein BUD31 homolog

1

1

High-throughput

0.536

High

278419

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

1

High-throughput

0.536

High

278421

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

278422

RBM6
RNA-binding protein 6

1

1

High-throughput

0.536

High

278429

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.536

High

278437

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

1

High-throughput

0.536

High

278445

RBM39
RNA-binding protein 39

1

1

High-throughput

0.536

High

278447

DHX8
ATP-dependent RNA helicase DHX8

1

2

High-throughput

0.536

High

278458

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.536

High

278460

C19L2
CWF19-like protein 2

1

1

High-throughput

0.536

High

278467

C19L1
CWF19-like protein 1

1

1

High-throughput

0.536

High

278523

GPTC1
G patch domain-containing protein 1

1

1

High-throughput

0.536

High

278528

CRNL1
Crooked neck-like protein 1

1

3

High-throughput

0.536

High

278532

PININ
Pinin

1

1

High-throughput

0.536

High

278535

DHX35
Probable ATP-dependent RNA helicase DHX35

1

3

High-throughput

0.536

High

278541

SYF1
Pre-mRNA-splicing factor SYF1

1

3

High-throughput

0.536

High

278562

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

1

High-throughput

0.536

High

278427

Q05BL1
TP53BP2 protein

1

2

High-throughput

0.515

High

176330

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

204577

E41L2
Band 4.1-like protein 2

1

0

High-throughput

0.513

High

278372

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.513

High

278375

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

278383

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

278389

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.513

High

278403

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.513

High

278407

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

278410

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.513

High

278416

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.513

High

278417

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

278440

CUL1
Cullin-1

1

0

High-throughput

0.513

High

278443

KGP1
cGMP-dependent protein kinase 1

1

0

High-throughput

0.513

High

278455

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

278469

KDM4D
Lysine-specific demethylase 4D

1

0

High-throughput

0.513

High

278479

MET23
Histone-arginine methyltransferase METTL23

1

0

High-throughput

0.513

High

278481

GCC2
GRIP and coiled-coil domain-containing protein 2

1

0

High-throughput

0.513

High

278487

ZBT8B
Zinc finger and BTB domain-containing protein 8B

1

0

High-throughput

0.513

High

278495

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.513

High

278505

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.513

High

278521

RBM4B
RNA-binding protein 4B

1

0

High-throughput

0.513

High

278547

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

278570

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

0

High-throughput

0.513

High

278571

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.513

High

278572

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

0

High-throughput

0.513

High

278573

RBGP1
Rab GTPase-activating protein 1

1

0

High-throughput

0.513

High

278456

SF01
Splicing factor 1

1

1

High-throughput

0.508

High

278374

PRGR
Progesterone receptor

1

2

Small-scale

0.501

High

278402

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.501

High

157845

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

278484

KT222
Keratin-like protein KRT222

1

7

High-throughput

0.489

High

278430

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.481

High

278441

ASPP2
Apoptosis-stimulating of p53 protein 2

1

2

High-throughput

0.481

High

278485

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.481

High

278496

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

1

High-throughput

0.481

High

278515

QKI
KH domain-containing RNA-binding protein QKI

1

1

High-throughput

0.481

High

278381

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

226090

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

267816

EED
Polycomb protein EED

1

4

High-throughput

0.479

High

278370

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

278371

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

278393

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

278396

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

Small-scale

0.479

High

278406

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

278413

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.479

High

278420

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.479

High

278431

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

278448

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

278451

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.479

High

278462

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

278478

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

278563

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.479

High

278568

SRRM2
Serine/arginine repetitive matrix protein 2

1

1

High-throughput

0.479

High

278385

GFAP
Glial fibrillary acidic protein

1

3

High-throughput

0.470

High

278363

CNOT4
CCR4-NOT transcription complex subunit 4

1

0

High-throughput

0.460

High

278399

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

High-throughput

0.460

High

278405

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.460

High

278409

FHIT
Bis(5'-adenosyl)-triphosphatase

1

0

High-throughput

0.460

High

278411

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.460

High

278503

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

278514

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

0

High-throughput

0.460

High

278545

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.460

High

278546

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

278549

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.460

High

278553

TSAP1
tRNA selenocysteine 1-associated protein 1

1

0

High-throughput

0.460

High

278558

ZMAT5
Zinc finger matrin-type protein 5

1

0

High-throughput

0.460

High

278569

NIP7
60S ribosome subunit biogenesis protein NIP7 homolog

1

0

High-throughput

0.460

High

122414

MEN1
Menin

1

0

High-throughput

0.458

High

125055

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

246516

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

255386

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

278360

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

278377

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

278390

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

278398

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

278408

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

278412

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

278415

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

278418

H4
Histone H4

1

0

High-throughput

0.458

High

278424

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

278432

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

278434

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

278436

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

278438

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

278449

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

278454

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.458

High

278459

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

278473

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

278476

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

0

High-throughput

0.458

High

278483

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

278491

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

278494

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

278510

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

278519

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

278537

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

0

High-throughput

0.458

High

278543

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

278544

ANLN
Anillin

1

0

High-throughput

0.458

High

278551

DJC17
DnaJ homolog subfamily C member 17

1

0

High-throughput

0.458

High

278556

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

278559

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

278574

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

278365

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.445

High

278373

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

278464

PRC2B
Protein PRRC2B

1

1

High-throughput

0.439

High

278474

LARP4
La-related protein 4

1

1

High-throughput

0.439

High

278560

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

1

High-throughput

0.437

High

278382

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.426

High

278442

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.426

High

278463

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.426

High

278428

GOGA2
Golgin subfamily A member 2

5

0

High-throughput

0.377

High

278511

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

278364

K2C75
Keratin, type II cytoskeletal 75

2

0

High-throughput

0.316

High

278426

ACY1
Aminoacylase-1

2

0

High-throughput

0.316

High

278457

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.316

High

278461

KR196
Keratin-associated protein 19-6

2

0

High-throughput

0.316

High

278465

MIIP
Migration and invasion-inhibitory protein

2

0

High-throughput

0.316

High

278477

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

278480

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

278493

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

278509

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

278513

CCD17
Coiled-coil domain-containing protein 17

2

0

High-throughput

0.316

High

278548

EMIL3
EMILIN-3

2

0

High-throughput

0.316

High

278550

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.316

High

278433

TRAF1
TNF receptor-associated factor 1

1

0

High-throughput

0.292

High

278366

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

278444

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

278446

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

278490

LINES
Protein Lines homolog 1

1

0

High-throughput

0.279

Low

278507

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

278540

ZDBF2
DBF4-type zinc finger-containing protein 2

1

0

High-throughput

0.279

Low

278498

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

278526

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

278542

TRXR2
Thioredoxin reductase 2, mitochondrial

1

0

Small-scale

0.261

Low

278482

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

0

High-throughput

0.251

Low

278489

SLAI1
SLAIN motif-containing protein 1

1

0

High-throughput

0.251

Low

148227

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

278471

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

278512

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

278534

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

278539

RC3H2
Roquin-2

1

0

High-throughput

0.249

Low

239657

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

278361

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.232

Low

278466

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.232

Low

278472

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.232

Low

278516

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024