Protein: CPSF1
Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)

Gene: CPSF1
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q10570

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex
GO:0019899 - enzyme binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317827

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

4

4

High-throughput

0.895

High

1014197

WDR33
pre-mRNA 3' end processing protein WDR33

4

17

Small-scale

0.860

High

726776

FUS
RNA-binding protein FUS

2

7

Small-scale

0.789

High

1014134

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

5

High-throughput

0.789

High

1014109

CSTF3
Cleavage stimulation factor subunit 3

2

5

Small-scale

0.768

High

1014186

RBM14
RNA-binding protein 14

2

0

Small-scale

0.748

High

1014201

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

1

Small-scale

0.715

High

1014153

FIP1
Pre-mRNA 3'-end-processing factor FIP1

4

2

Small-scale

0.698

High

1014217

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

4

8

Small-scale

0.694

High

446604

SNRPA
U1 small nuclear ribonucleoprotein A

1

7

High-throughput

0.691

High

833873

CLK2
Dual specificity protein kinase CLK2

1

4

High-throughput

0.691

High

1014117

CUL3
Cullin-3

1

18

High-throughput

0.691

High

1014174

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

9

High-throughput

0.691

High

1014224

CILK1
Serine/threonine-protein kinase ICK

1

1

High-throughput

0.691

High

346635

MYC
Myc proto-oncogene protein

4

5

Small-scale

0.676

High

1014177

SYMPK
Symplekin

3

2

High-throughput

0.656

High

1014128

TAF5
Transcription initiation factor TFIID subunit 5

1

10

Small-scale

0.647

High

1014204

ANLN
Anillin

3

2

High-throughput

0.640

High

1014211

CPSF2
Cleavage and polyadenylation specificity factor subunit 2

3

8

Small-scale

0.640

High

253256

KI21B
Kinesin-like protein KIF21B

1

1

High-throughput

0.618

High

851472

NEK4
Serine/threonine-protein kinase Nek4

1

8

High-throughput

0.618

High

197009

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

11

High-throughput

0.618

High

268047

EED
Polycomb protein EED

1

16

High-throughput

0.618

High

325707

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.618

High

374124

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.618

High

442104

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

7

High-throughput

0.618

High

703376

CSTF2
Cleavage stimulation factor subunit 2

1

5

Small-scale

0.618

High

833421

RBM25
RNA-binding protein 25

1

3

High-throughput

0.618

High

841682

CDK9
Cyclin-dependent kinase 9

1

4

High-throughput

0.618

High

852027

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

2

Small-scale

0.618

High

925015

TRA2B
Transformer-2 protein homolog beta

1

4

High-throughput

0.618

High

1014111

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.618

High

1014115

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

10

High-throughput

0.618

High

1014118

CUL4A
Cullin-4A

1

18

Small-scale

0.618

High

1014166

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

2

High-throughput

0.618

High

1014173

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

1

High-throughput

0.618

High

1014178

RBP56
TATA-binding protein-associated factor 2N

1

7

Small-scale

0.618

High

1014187

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

2

High-throughput

0.618

High

1014208

NLE1
Notchless protein homolog 1

1

7

High-throughput

0.618

High

1014222

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.618

High

1014209

WWOX
WW domain-containing oxidoreductase

2

1

High-throughput

0.608

High

624876

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

3

Small-scale

0.602

High

1014131

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.586

High

843538

PAPOA
Poly(A) polymerase alpha

2

4

Small-scale

0.585

High

552583

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

651055

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

High-throughput

0.584

High

720323

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

1014135

HIF1A
Hypoxia-inducible factor 1-alpha

2

7

Small-scale

0.584

High

1014159

RBBP6
E3 ubiquitin-protein ligase RBBP6

2

3

Small-scale

0.584

High

1012225

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1014124

RHG19
Rho GTPase-activating protein 19

2

7

High-throughput

0.571

High

1014151

RHGBA
Rho GTPase-activating protein 11A

2

5

High-throughput

0.571

High

148732

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.553

High

1014123

CUL7
Cullin-7

1

2

High-throughput

0.553

High

981564

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.549

High

1014196

GLIS2
Zinc finger protein GLIS2

1

3

Small-scale

0.541

High

236755

CCNT1
Cyclin-T1

1

4

High-throughput

0.536

High

448629

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

508479

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

538925

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

996632

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

1014116

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

1014157

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.536

High

1014203

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

2

High-throughput

0.536

High

1014212

HDAC6
Histone deacetylase 6

1

11

High-throughput

0.536

High

322530

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

4

High-throughput

0.533

High

1014161

ZCH18
Zinc finger CCCH domain-containing protein 18

2

7

High-throughput

0.533

High

1014138

RHG29
Rho GTPase-activating protein 29

2

5

High-throughput

0.521

High

1014132

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.515

High

418211

NPM
Nucleophosmin

1

0

Small-scale

0.513

High

1014148

CDC73
Parafibromin

1

0

Small-scale

0.513

High

1014164

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

820898

PRC2A
Protein PRRC2A

1

4

Small-scale

0.508

High

475673

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

808107

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

High-throughput

0.501

High

1014133

TAF12
Transcription initiation factor TFIID subunit 12

1

1

Small-scale

0.501

High

1014195

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

2

High-throughput

0.500

High

942041

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.493

High

1014170

ARRD2
Arrestin domain-containing protein 2

1

2

High-throughput

0.489

High

1014182

ARRD3
Arrestin domain-containing protein 3

1

2

High-throughput

0.489

High

1014129

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.480

High

125413

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

205327

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

227288

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

233404

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

241514

H2B1K
Histone H2B type 1-K

1

5

High-throughput

0.479

High

244349

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

261486

NCOR1
Nuclear receptor corepressor 1

1

4

High-throughput

0.479

High

263607

PR40A
Pre-mRNA-processing factor 40 homolog A

1

12

High-throughput

0.479

High

269225

WBP4
WW domain-binding protein 4

1

7

High-throughput

0.479

High

298465

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

300416

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

2

High-throughput

0.479

High

304141

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

High-throughput

0.479

High

308653

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

379335

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.479

High

486900

MYBB
Myb-related protein B

1

3

High-throughput

0.479

High

487376

ANDR
Androgen receptor

1

5

High-throughput

0.479

High

503977

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

632708

TYY1
Transcriptional repressor protein YY1

1

5

High-throughput

0.479

High

764637

CUX1
Homeobox protein cut-like 1

1

1

High-throughput

0.479

High

779308

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

897235

CSN2
COP9 signalosome complex subunit 2

1

4

Small-scale

0.479

High

908448

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

917172

H4
Histone H4

1

4

High-throughput

0.479

High

918320

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.479

High

959375

VIGLN
Vigilin

1

4

High-throughput

0.479

High

961075

HSF1
Heat shock factor protein 1

1

2

High-throughput

0.479

High

969649

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

998611

EP300
Histone acetyltransferase p300

1

10

High-throughput

0.479

High

1014110

CSN1
COP9 signalosome complex subunit 1

1

4

Small-scale

0.479

High

1014112

IKZF1
DNA-binding protein Ikaros

1

5

High-throughput

0.479

High

1014113

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

3

High-throughput

0.479

High

1014114

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1014119

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

5

High-throughput

0.479

High

1014120

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

8

High-throughput

0.479

High

1014125

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.479

High

1014126

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

1014130

NCOA2
Nuclear receptor coactivator 2

1

7

High-throughput

0.479

High

1014141

ZN362
Zinc finger protein 362

1

3

High-throughput

0.479

High

1014143

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

4

High-throughput

0.479

High

1014145

TSH3
Teashirt homolog 3

1

1

High-throughput

0.479

High

1014147

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1014152

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

2

High-throughput

0.479

High

1014156

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

High-throughput

0.479

High

1014158

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1014160

SLN11
Schlafen family member 11

1

2

Small-scale

0.479

High

1014162

DDX42
ATP-dependent RNA helicase DDX42

1

2

High-throughput

0.479

High

1014163

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

1

Small-scale

0.479

High

1014165

SRRM1
Serine/arginine repetitive matrix protein 1

1

4

High-throughput

0.479

High

1014167

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1014168

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

High-throughput

0.479

High

1014171

SP7
Transcription factor Sp7

1

4

High-throughput

0.479

High

1014172

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1014175

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

1014176

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.479

High

1014179

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.479

High

1014181

FUBP1
Far upstream element-binding protein 1

1

2

High-throughput

0.479

High

1014184

ZBT10
Zinc finger and BTB domain-containing protein 10

1

3

High-throughput

0.479

High

1014190

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1014191

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

1

Small-scale

0.479

High

1014193

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.479

High

1014198

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.479

High

1014199

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

9

High-throughput

0.479

High

1014205

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

1014207

SALL1
Sal-like protein 1

1

3

High-throughput

0.479

High

1014213

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1014214

TCF20
Transcription factor 20

1

1

High-throughput

0.479

High

1014218

GPTC8
G patch domain-containing protein 8

1

1

High-throughput

0.479

High

1014219

IKZF3
Zinc finger protein Aiolos

1

6

High-throughput

0.479

High

1014220

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1014221

YETS2
YEATS domain-containing protein 2

1

1

High-throughput

0.479

High

1014223

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

1014225

ZN148
Zinc finger protein 148

1

4

High-throughput

0.479

High

1014226

NUDC
Nuclear migration protein nudC

1

4

High-throughput

0.479

High

1014183

DDT4L
DNA damage-inducible transcript 4-like protein

1

1

High-throughput

0.470

High

122703

MEN1
Menin

1

0

High-throughput

0.458

High

202427

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.458

High

396924

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

416974

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

589846

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

827921

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

940687

NOP14
Nucleolar protein 14

1

0

High-throughput

0.458

High

1014108

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.458

High

1014142

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.458

High

1014150

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

High-throughput

0.458

High

1014169

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1014180

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1014189

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.458

High

1014206

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1014215

DACH1
Dachshund homolog 1

1

0

High-throughput

0.458

High

717757

BMI1
Polycomb complex protein BMI-1

1

5

High-throughput

0.445

High

1014122

CASP8
Caspase-8

1

2

High-throughput

0.445

High

1014127

PCBP2
Poly(rC)-binding protein 2

1

4

Small-scale

0.445

High

1014139

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.445

High

1014202

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

1014216

DDX41
Probable ATP-dependent RNA helicase DDX41

1

3

High-throughput

0.445

High

255724

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

384729

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

932120

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.437

High

1014136

QSER1
Glutamine and serine-rich protein 1

1

4

High-throughput

0.437

High

1014144

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

1014155

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1014192

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

1

High-throughput

0.437

High

1014200

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1014188

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

306136

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

5

High-throughput

0.407

High

1014154

NBEL2
Neurobeachin-like protein 2

1

10

High-throughput

0.407

High

1014185

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

1014194

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.407

High

1014227

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

4

High-throughput

0.407

High

847453

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.249

Low

1014121

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

1014137

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

1014140

FA76B
Protein FAM76B

1

0

High-throughput

0.249

Low

1014149

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

1014210

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

High-throughput

0.249

Low

1014146

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024