Protein: SPY
Protein sprouty (Spry)

Gene: SPY, sty
Organism: Drosophila melanogaster
Interactions: 88
UniProt ID: O44783

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001745 - compound eye morphogenesis
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007424 - open tracheal system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

233509

SYB
Synaptobrevin

2

1

High-throughput

0.571

High

233529

Q8IPV3
Uncharacterized protein, isoform A

2

1

High-throughput

0.571

High

233514

GRAP
Growth factor receptor-bound protein 2

2

16

High-throughput

0.552

High

233560

FRL
Formin-like protein

2

0

High-throughput

0.547

High

233562

Q9VVG2
Proline-rich extensin-like protein EPR1

2

3

High-throughput

0.543

High

233535

Q95R82
SD02746p

2

1

High-throughput

0.521

High

233503

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

3

High-throughput

0.508

High

233504

BTKL
Tyrosine-protein kinase Btk

1

3

High-throughput

0.508

High

233506

7LESS
Protein sevenless

1

5

High-throughput

0.508

High

233515

ICCR
Irregular chiasm C-roughest protein

1

5

High-throughput

0.508

High

56501

A1ZAA5
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.486

High

233530

MOB2
MOB kinase activator-like 2

1

0

High-throughput

0.486

High

233540

SPIR
Protein spire

1

0

High-throughput

0.486

High

233547

CARM1
Probable histone-arginine methyltransferase CARMER

1

0

High-throughput

0.486

High

233571

Q9W374
Dihydropyrimidine dehydrogenase [NADP(+)]

1

0

High-throughput

0.486

High

52868

A1Z7C4
LDL receptor protein 1, isoform G

1

1

High-throughput

0.481

High

56101

APKC
Atypical protein kinase C

1

1

High-throughput

0.481

High

233505

LAMB1
Laminin subunit beta-1

1

3

High-throughput

0.481

High

233508

SERR
Protein serrate

1

3

High-throughput

0.481

High

233519

Q2PDT4
Paxillin, isoform F

1

8

High-throughput

0.481

High

233550

Q9VJW9
ADAM10 endopeptidase

1

2

High-throughput

0.481

High

233575

X2JE09
Terribly reduced optic lobes, isoform AV

1

3

High-throughput

0.481

High

117893

M9MRE1
PDGF- and VEGF-receptor related, isoform K

1

3

High-throughput

0.479

High

233541

Q9V3C8
DShc protein

1

12

High-throughput

0.479

High

233563

NEDD4
E3 ubiquitin-protein ligase Nedd-4

1

3

High-throughput

0.479

High

233507

LAMC1
Laminin subunit gamma-1

1

3

High-throughput

0.464

High

233510

DISC
Protein disconnected

1

1

High-throughput

0.464

High

233513

BSH
Brain-specific homeobox protein

1

2

High-throughput

0.464

High

233534

Q8T3W6
AT27166p

1

1

High-throughput

0.464

High

233552

Q9VLK3
Beta-site APP-cleaving enzyme, isoform A

1

2

High-throughput

0.464

High

69030

A8JRD7
Uncharacterized protein, isoform B

1

0

High-throughput

0.460

High

233511

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.460

High

233525

Q7KTD0
ABC-type glutathione-S-conjugate transporter

1

0

High-throughput

0.460

High

233548

Q9VJJ9
FI20237p1

1

0

High-throughput

0.460

High

233537

Q95U21
receptor protein serine/threonine kinase

1

0

High-throughput

0.458

High

233501

O96692
small monomeric GTPase

1

8

High-throughput

0.445

High

233523

Q7K0X9
LD23667p

1

1

High-throughput

0.445

High

233528

Q8IPG1
PDGF- and VEGF-receptor related, isoform B

1

3

High-throughput

0.445

High

233555

Q9VPJ7
FI05267p

1

1

High-throughput

0.445

High

85006

B7Z143
Protein interacting with Ttk69 and Sin3A, isoform D

1

1

High-throughput

0.439

High

95088

E1JHA6
Uninflatable, isoform C

1

3

High-throughput

0.439

High

96050

E8NH67
Asperous, isoform B

1

3

High-throughput

0.439

High

121494

M9PFE4
Palmitoyltransferase

1

10

High-throughput

0.439

High

233512

LAMA
Laminin subunit alpha

1

4

High-throughput

0.439

High

233522

Q7K0W0
LD27413p

1

1

High-throughput

0.439

High

233526

Q7KUB3
Ecdysone-inducible gene E1, isoform A

1

2

High-throughput

0.439

High

233527

PPN
Papilin

1

3

High-throughput

0.439

High

233533

Q8MR04
LP02978p

1

1

High-throughput

0.439

High

233536

Q95SJ2
GEO04222p1

1

1

High-throughput

0.439

High

233543

Q9VB21
Uncharacterized protein

1

1

High-throughput

0.439

High

233556

HERC2
Probable E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.439

High

233558

Q9VTR8
Uncharacterized protein, isoform B

1

4

High-throughput

0.439

High

233559

Q9VU43
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.439

High

233566

Q9VX18
Suppressor of cytokine signaling at 16D, isoform A

1

6

High-throughput

0.439

High

233574

X2JDS9
Visual system homeobox 2

1

11

High-throughput

0.439

High

50248

A1A714
IP17403p

1

1

High-throughput

0.437

High

233517

Q1ECB1
Membrane protein BRI3

1

1

High-throughput

0.437

High

56151

A1Z9Z1
RE70407p

1

1

High-throughput

0.417

High

233554

Q9VM81
Uncharacterized protein, isoform D

1

1

High-throughput

0.417

High

233567

Q9VYL7
Protein interacting with Ttk69 and Sin3A, isoform C

1

1

High-throughput

0.417

High

233572

Q9W4B3
Visual system homeobox 2

1

11

High-throughput

0.417

High

233538

Q960F6
SD03655p

1

1

High-throughput

0.407

High

233568

Q9VZP9
Membrane protein BRI3

1

1

High-throughput

0.407

High

233500

O46034
E3 ubiquitin-protein ligase CBL

1

7

High-throughput

0.381

High

233502

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.381

High

233516

FGFR2
Fibroblast growth factor receptor homolog 2

1

2

High-throughput

0.381

High

233531

Q8IR23
GH13542p

1

14

High-throughput

0.381

High

233544

Q9VBF0
Ras modification protein ERF4

2

0

High-throughput

0.298

High

233565

Q9VW70
FI21813p1

2

0

High-throughput

0.298

High

233521

Q7JWN2
RE25177p

1

0

High-throughput

0.265

Low

233545

Q9VCJ2
CRAL-TRIO domain-containing protein

1

0

High-throughput

0.265

Low

233549

Q9VJM1
GEO13348p1

1

0

High-throughput

0.265

Low

233551

Q9VKV9
Methionine aminopeptidase

1

0

High-throughput

0.265

Low

233561

Q9VV58
GH01515p

1

0

High-throughput

0.265

Low

233573

Q9XTN4
Brinker

1

0

High-throughput

0.265

Low

121037

M9PEP8
Muscle-specific protein 300 kDa, isoform M

1

0

High-throughput

0.251

Low

233518

Q29R20
Dipeptidase

1

0

High-throughput

0.251

Low

233532

Q8MLU9
DUF753 domain-containing protein

1

0

High-throughput

0.251

Low

233542

Q9VA66
Jonah 99Fi

1

0

High-throughput

0.251

Low

233546

Q9VE45
Mucin 91C, isoform A

1

0

High-throughput

0.251

Low

233553

Q9VLW9
Homocysteine-induced endoplasmic reticulum protein, isoform A

1

0

High-throughput

0.251

Low

233557

Q9VRG8
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.251

Low

233569

Q9W214
Partner of Paired

1

0

High-throughput

0.251

Low

233520

Q4V5V8
IP11774p

1

0

High-throughput

0.238

Low

233524

Q7K1R6
LD46221p

1

0

High-throughput

0.232

Low

233539

XPO1
Exportin-1

1

0

High-throughput

0.232

Low

233564

Q9VVJ5
Nedd4 family interacting protein

1

0

High-throughput

0.232

Low

233570

Q9W2V9
LD40707p

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025