Protein: PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)

Gene: PDE5A
Organism: Homo sapiens
Interactions: 16
UniProt ID: O76074

Gene Ontology (top 5):
GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005829 - cytosol
GO:0010613 - positive regulation of cardiac muscle hypertrophy
GO:0010749 - regulation of nitric oxide mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

283088

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

2

5

High-throughput

0.628

High

283087

SPG21
Maspardin

2

0

High-throughput

0.580

High

283080

KGP1
cGMP-dependent protein kinase 1

1

6

Small-scale

0.500

High

283083

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.493

High

283084

WDR24
GATOR2 complex protein WDR24

1

4

High-throughput

0.479

High

283086

MIOS
GATOR2 complex protein MIOS

1

1

High-throughput

0.479

High

283076

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

283077

BLM
RecQ-like DNA helicase BLM

1

0

High-throughput

0.458

High

283085

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

0

High-throughput

0.458

High

283081

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

3

Small-scale

0.457

High

283078

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

High-throughput

0.445

High

283075

RHBT1
Rho-related BTB domain-containing protein 1

1

3

Small-scale

0.437

High

283082

FKB15
FK506-binding protein 15

1

1

High-throughput

0.437

High

283079

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.407

High

198145

MSH5
MutS protein homolog 5

1

0

High-throughput

0.279

Low

123809

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024