Protein: CREM
cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)

Gene: CREM
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q03060

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

556846

CREB1
Cyclic AMP-responsive element-binding protein 1

2

13

Small-scale

0.789

High

974401

CBP
CREB-binding protein

1

6

Small-scale

0.647

High

891380

IL2
Interleukin-2

3

1

Small-scale

0.640

High

974395

FHL5
Four and a half LIM domains protein 5

2

7

Small-scale

0.633

High

345403

FOS
Protein c-Fos

1

18

Small-scale

0.618

High

974386

CREM
cAMP-responsive element modulator

1

17

Small-scale

0.618

High

974399

CR3L4
Cyclic AMP-responsive element-binding protein 3-like protein 4

1

18

Small-scale

0.618

High

308072

VENTX
Homeobox protein VENTX

2

4

High-throughput

0.606

High

540839

PO2F1
POU domain, class 2, transcription factor 1

2

4

High-throughput

0.606

High

906759

NCS1
Neuronal calcium sensor 1

2

7

High-throughput

0.606

High

950450

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

5

High-throughput

0.606

High

968358

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

2

1

High-throughput

0.606

High

974394

UBAP2
Ubiquitin-associated protein 2

2

1

High-throughput

0.606

High

974405

RHXF2
Rhox homeobox family member 2

2

3

High-throughput

0.606

High

974406

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

2

10

High-throughput

0.606

High

974409

GLIS2
Zinc finger protein GLIS2

2

6

High-throughput

0.606

High

146484

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.580

High

448619

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

538915

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

0

High-throughput

0.580

High

974407

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

974389

HDAC1
Histone deacetylase 1

1

5

Small-scale

0.578

High

740656

HPCL1
Hippocalcin-like protein 1

2

5

High-throughput

0.553

High

901302

NCALD
Neurocalcin-delta

2

5

High-throughput

0.553

High

617289

SP100
Nuclear autoantigen Sp-100

1

8

High-throughput

0.541

High

974388

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

868436

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

974417

DNM3A
DNA

1

4

Small-scale

0.515

High

803496

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.515

High

974404

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

974410

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

974403

MIA2
Melanoma inhibitory activity protein 2

2

4

High-throughput

0.504

High

124200

TAF4
Transcription initiation factor TFIID subunit 4

1

2

Small-scale

0.501

High

572558

SPI1
Transcription factor PU.1

1

8

Small-scale

0.501

High

647549

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.501

High

974414

DNM3L
DNA

1

4

Small-scale

0.501

High

974416

CSEN
Calsenilin

1

9

Small-scale

0.501

High

873281

EMP3
Epithelial membrane protein 3

1

3

High-throughput

0.494

High

827917

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

Small-scale

0.486

High

930155

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

974418

PIAS3
E3 SUMO-protein ligase PIAS3

1

3

High-throughput

0.481

High

589838

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

352587

TNFA
Tumor necrosis factor

1

3

Small-scale

0.479

High

352926

IFNG
Interferon gamma

1

2

Small-scale

0.479

High

396341

APOD
Apolipoprotein D

1

3

Small-scale

0.479

High

594510

PSB1
Proteasome subunit beta type-1

1

1

Small-scale

0.479

High

751586

GRP75
Stress-70 protein, mitochondrial

1

5

Small-scale

0.479

High

783018

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

Small-scale

0.479

High

850008

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

Small-scale

0.479

High

885156

FOXL2
Forkhead box protein L2

1

7

Small-scale

0.479

High

917142

H4
Histone H4

1

3

High-throughput

0.479

High

944193

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

Small-scale

0.479

High

974387

MECOM
Histone-lysine N-methyltransferase MECOM

1

4

High-throughput

0.479

High

974391

IMB1
Importin subunit beta-1

1

2

Small-scale

0.479

High

974396

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

Small-scale

0.479

High

974397

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

974400

GCN1
Stalled ribosome sensor GCN1

1

2

Small-scale

0.479

High

974402

TNPO1
Transportin-1

1

2

Small-scale

0.479

High

974408

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

Small-scale

0.479

High

974411

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

974412

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

974413

DDX41
Probable ATP-dependent RNA helicase DDX41

1

3

Small-scale

0.479

High

974415

C8AP2
CASP8-associated protein 2

1

0

High-throughput

0.460

High

242436

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

Small-scale

0.458

High

396852

IL4
Interleukin-4

1

0

Small-scale

0.458

High

637859

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

656701

PSB5
Proteasome subunit beta type-5

1

0

Small-scale

0.458

High

667950

SPB3
Serpin B3

1

0

Small-scale

0.458

High

678439

S10A7
Protein S100-A7

1

0

Small-scale

0.458

High

796839

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

Small-scale

0.458

High

974392

NEDD8
NEDD8

1

0

Small-scale

0.458

High

312247

IPO7
Importin-7

1

2

Small-scale

0.437

High

453959

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

Small-scale

0.437

High

643847

SYVC
Valine--tRNA ligase

1

1

Small-scale

0.437

High

974398

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

609258

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

376557

CSF2
Granulocyte-macrophage colony-stimulating factor

1

0

Small-scale

0.249

Low

555128

CD44
CD44 antigen

1

0

Small-scale

0.249

Low

599791

5NTD
5'-nucleotidase

1

0

Small-scale

0.249

Low

974390

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.249

Low

974393

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024