Protein: IRS1
Insulin receptor substrate 1 (dIRS) (Protein chico)

Gene: IRS1, chico
Organism: Drosophila melanogaster
Interactions: 36
UniProt ID: Q9XTN2

Gene Ontology (top 5):
GO:0005158 - insulin receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1264641

Q7K137
LD10453p

2

17

Small-scale

0.768

High

479740

INSR
Insulin-like receptor

8

16

Small-scale

0.746

High

1489196

DOS
Protein daughter of sevenless

2

2

High-throughput

0.737

High

709604

1433Z
14-3-3 protein zeta

4

20

Small-scale

0.686

High

1019970

1433E
14-3-3 protein epsilon

4

5

Small-scale

0.686

High

1477979

Q9VJ14
RING-type E3 ubiquitin transferase

3

3

High-throughput

0.650

High

119642

M9PAY7
Pi3K21B, isoform C

3

20

High-throughput

0.640

High

1019267

P91634
phosphatidylinositol 3-kinase

2

7

High-throughput

0.584

High

198240

O18683
LD42724p

2

20

High-throughput

0.538

High

875580

PELO
Protein pelota

1

0

High-throughput

0.486

High

263589

FLOT1
Flotillin-1

1

3

High-throughput

0.479

High

263641

FLOT2
Flotillin-2

1

3

High-throughput

0.479

High

715391

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

782839

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

2

High-throughput

0.479

High

786412

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

1

1

High-throughput

0.479

High

1197215

RBP9X
Ran-binding proteins 9/10 homolog

1

2

High-throughput

0.479

High

122112

M9PHL4
IST1 homolog

1

1

High-throughput

0.437

High

1379512

Q961X4
Combover, isoform B

1

1

High-throughput

0.437

High

1490302

Q9Y162
vesicle-fusing ATPase

1

1

High-throughput

0.437

High

1484530

Q9VR03
AT19250p

1

0

High-throughput

0.426

High

1485266

Q9VRY6
IST1 homolog

1

1

High-throughput

0.407

High

1486568

Q9VU76
Combover, isoform A

1

1

High-throughput

0.407

High

1061488

GRAP
Growth factor receptor-bound protein 2

1

13

High-throughput

0.381

High

1487330

CHMP5
Charged multivesicular body protein 5

2

0

High-throughput

0.298

High

234959

PGAM5
Serine/threonine-protein phosphatase Pgam5, mitochondrial

1

0

High-throughput

0.279

Low

479645

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.249

Low

559191

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.249

Low

856491

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.249

Low

870561

RS15A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

939010

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.249

Low

1477994

Q9VJ19
Large ribosomal subunit protein eL30

1

0

High-throughput

0.249

Low

1485325

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.249

Low

1487717

Q9VW70
FI21813p1

1

0

High-throughput

0.249

Low

1489930

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.249

Low

1320688

Q8MLQ0
FI14118p

1

0

High-throughput

0.232

Low

1377983

Q95SH2
Charged multivesicular body protein 1, isoform A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025