Protein: RHEB
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)

Gene: RHEB
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q15382

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787491

MTOR
Serine/threonine-protein kinase mTOR

9

15

Small-scale

0.974

High

835062

TSC2
Tuberin

7

12

Small-scale

0.971

High

374271

RAF1
RAF proto-oncogene serine/threonine-protein kinase

5

20

Small-scale

0.927

High

1052984

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

3

1

Small-scale

0.863

High

925298

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

High-throughput

0.811

High

542884

BRAF
Serine/threonine-protein kinase B-raf

2

20

Small-scale

0.754

High

1032967

PLD1
Phospholipase D1

1

3

Small-scale

0.747

High

1031531

ATM
Serine-protein kinase ATM

1

13

Small-scale

0.724

High

1072650

RPTOR
Regulatory-associated protein of mTOR

5

5

Small-scale

0.713

High

530173

NCAM1
Neural cell adhesion molecule 1

1

3

High-throughput

0.698

High

919086

RAN
GTP-binding nuclear protein Ran

1

20

High-throughput

0.665

High

217726

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

3

3

Small-scale

0.665

High

1038117

ATR
Serine/threonine-protein kinase ATR

1

13

Small-scale

0.648

High

616711

KS6B1
Ribosomal protein S6 kinase beta-1

1

2

Small-scale

0.647

High

1072661

LST8
Target of rapamycin complex subunit LST8

3

3

Small-scale

0.640

High

352622

TNFA
Tumor necrosis factor

3

0

High-throughput

0.638

High

475032

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

11

High-throughput

0.628

High

1054766

CASL
Enhancer of filamentation 1

2

8

High-throughput

0.628

High

1072668

I20RA
Interleukin-20 receptor subunit alpha

2

5

High-throughput

0.628

High

1072674

SRPRB
Signal recognition particle receptor subunit beta

2

20

High-throughput

0.628

High

527463

LAMP2
Lysosome-associated membrane glycoprotein 2

2

20

High-throughput

0.621

High

1072672

PKHM1
Pleckstrin homology domain-containing family M member 1

1

10

Small-scale

0.618

High

349334

RASH
GTPase HRas

1

20

Small-scale

0.618

High

919633

RAP1A
Ras-related protein Rap-1A

1

20

Small-scale

0.618

High

1072664

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1072665

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1072655

TSC1
Hamartin

2

20

Small-scale

0.595

High

216733

CREB3
Cyclic AMP-responsive element-binding protein 3

2

2

High-throughput

0.590

High

1024344

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

Small-scale

0.578

High

1072651

RN152
E3 ubiquitin-protein ligase RNF152

1

4

Small-scale

0.578

High

791578

HD
Huntingtin

1

8

Small-scale

0.561

High

868194

ATX3
Ataxin-3

1

2

Small-scale

0.561

High

1072656

APBP2
Amyloid protein-binding protein 2

2

3

High-throughput

0.553

High

1072645

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

1022017

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

1

2

Small-scale

0.552

High

344494

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.541

High

834973

PSN2
Presenilin-2

1

2

High-throughput

0.541

High

1072658

TRI63
E3 ubiquitin-protein ligase TRIM63

1

19

High-throughput

0.541

High

1072662

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

532532

TCTP
Translationally-controlled tumor protein

1

1

Small-scale

0.536

High

172002

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.536

High

557133

PGFRA
Platelet-derived growth factor receptor alpha

1

8

High-throughput

0.536

High

801161

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.536

High

814955

LEG7
Galectin-7

1

5

High-throughput

0.536

High

887109

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

1

High-throughput

0.536

High

1072644

ENPP7
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

1

1

High-throughput

0.536

High

1072652

RELL2
RELT-like protein 2

1

1

High-throughput

0.536

High

1072666

STMN3
Stathmin-3

1

1

High-throughput

0.536

High

1072673

ENTP2
Ectonucleoside triphosphate diphosphohydrolase 2

1

1

High-throughput

0.536

High

1072660

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.518

High

1020671

TRAF2
TNF receptor-associated factor 2

1

7

Small-scale

0.515

High

124409

HIP1
Huntingtin-interacting protein 1

1

5

High-throughput

0.515

High

263641

PR40A
Pre-mRNA-processing factor 40 homolog A

1

5

High-throughput

0.515

High

609296

FGFR3
Fibroblast growth factor receptor 3

1

15

High-throughput

0.515

High

877036

CASP6
Caspase-6

1

1

High-throughput

0.515

High

1060437

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

9

High-throughput

0.515

High

1072670

UBQL1
Ubiquilin-1

1

11

High-throughput

0.515

High

456414

PPBI
Intestinal-type alkaline phosphatase

1

0

High-throughput

0.513

High

801600

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.513

High

1072643

TM52B
Transmembrane protein 52B

1

0

High-throughput

0.513

High

1072649

VASH2
Tubulinyl-Tyr carboxypeptidase 2

1

0

High-throughput

0.513

High

225191

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

2

Small-scale

0.508

High

1072669

PRAF1
Prenylated Rab acceptor protein 1

1

14

Small-scale

0.508

High

312611

ARI2
E3 ubiquitin-protein ligase ARIH2

1

9

High-throughput

0.494

High

993953

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.493

High

413137

CCKN
Cholecystokinin

1

0

High-throughput

0.493

High

975658

LMNB2
Lamin-B2

1

6

High-throughput

0.489

High

1072659

TCPQM
T-complex protein 1 subunit theta-like 2

1

6

High-throughput

0.489

High

834287

PSN1
Presenilin-1

1

2

High-throughput

0.481

High

196306

PJA2
E3 ubiquitin-protein ligase Praja-2

1

16

Small-scale

0.479

High

377340

GCR
Glucocorticoid receptor

1

17

High-throughput

0.479

High

455471

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

639931

ITB8
Integrin beta-8

1

9

High-throughput

0.479

High

718879

PHB1
Prohibitin 1

1

13

High-throughput

0.479

High

974573

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

1036596

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

1072642

FSCN1
Fascin

1

1

High-throughput

0.479

High

1072654

DUS19
Dual specificity protein phosphatase 19

1

6

High-throughput

0.479

High

1072663

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

10

High-throughput

0.479

High

1072671

VPS4A
Vacuolar protein sorting-associated protein 4A

1

4

High-throughput

0.479

High

361487

APOE
Apolipoprotein E

1

0

High-throughput

0.460

High

1072648

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1072657

SC5A5
Sodium/iodide cotransporter

1

0

Small-scale

0.458

High

517269

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

346849

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

552792

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.437

High

651275

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

12

High-throughput

0.437

High

720531

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

824038

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

1072646

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

1072667

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

2

Small-scale

0.437

High

1072647

SPT19
Spermatogenesis-associated protein 19, mitochondrial

2

0

High-throughput

0.328

High

1072653

NF2IP
NFATC2-interacting protein

2

0

High-throughput

0.328

High

1072675

Q9Y649
GW128

1

0

High-throughput

0.268

Low

239585

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024