Protein: TSP1
Thrombospondin-1 (Glycoprotein G)

Gene: TSP1, THBS1
Organism: Homo sapiens
Interactions: 110
UniProt ID: P07996

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001786 - phosphatidylserine binding
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0001953 - negative regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

434628

TSP3
Thrombospondin-3

3

18

High-throughput

0.861

High

362706

FINC
Fibronectin

3

7

Small-scale

0.853

High

434641

LRP1
Prolow-density lipoprotein receptor-related protein 1

3

12

Small-scale

0.845

High

434621

TSP2
Thrombospondin-2

2

17

High-throughput

0.811

High

434640

CO7A1
Collagen alpha-1(VII) chain

2

12

Small-scale

0.786

High

358450

CO1A1
Collagen alpha-1(I) chain

2

9

Small-scale

0.778

High

434660

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.691

High

434668

SIRPD
Signal-regulatory protein delta

1

4

High-throughput

0.691

High

434676

OPT
Opticin

1

18

High-throughput

0.691

High

434679

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

14

High-throughput

0.691

High

358586

CO2A1
Collagen alpha-1(II) chain

1

9

Small-scale

0.647

High

358627

CO3A1

1

9

Small-scale

0.647

High

434610

CO6A1

1

7

Small-scale

0.647

High

434617

PGS1
Biglycan

1

20

Small-scale

0.647

High

434638

LRP2
Low-density lipoprotein receptor-related protein 2

1

4

Small-scale

0.647

High

434649

PCOC1
Procollagen C-endopeptidase enhancer 1

1

9

Small-scale

0.647

High

434600

TSP1
Thrombospondin-1

1

16

Small-scale

0.621

High

434623

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

17

Small-scale

0.621

High

434636

JAG1
Protein jagged-1

1

17

Small-scale

0.621

High

434622

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

19

Small-scale

0.618

High

341344

PLMN
Plasminogen

2

14

Small-scale

0.602

High

434632

FCGRN
IgG receptor FcRn large subunit p51

2

0

High-throughput

0.602

High

351223

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

2

5

Small-scale

0.595

High

396552

ITB3
Integrin beta-3

2

20

Small-scale

0.595

High

434637

TSG6
Tumor necrosis factor-inducible gene 6 protein

2

8

Small-scale

0.595

High

434670

DDX31
ATP-dependent DNA helicase DDX31

2

1

High-throughput

0.574

High

434602

MMP2
72 kDa type IV collagenase

1

8

Small-scale

0.552

High

393950

A4
Amyloid-beta precursor protein

1

13

Small-scale

0.536

High

434615

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.536

High

434618

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

Small-scale

0.536

High

211343

PI15
Peptidase inhibitor 15

1

4

High-throughput

0.536

High

319494

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.536

High

434605

LEG1
Galectin-1

1

12

High-throughput

0.536

High

434607

CFC1
Cryptic protein

1

5

High-throughput

0.536

High

434612

PRG2
Bone marrow proteoglycan

1

12

High-throughput

0.536

High

434631

MFAP4
Microfibril-associated glycoprotein 4

1

4

High-throughput

0.536

High

434652

LYPD4
Ly6/PLAUR domain-containing protein 4

1

2

High-throughput

0.536

High

434653

LYZL1
Lysozyme-like protein 1

1

3

High-throughput

0.536

High

434667

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

434669

KLK15
Kallikrein-15

1

14

High-throughput

0.536

High

434677

DNJB9
DnaJ homolog subfamily B member 9

1

4

High-throughput

0.536

High

434650

ELAV1
ELAV-like protein 1

1

1

Small-scale

0.515

High

311663

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

434648

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

125099

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

9

Small-scale

0.501

High

341130

THRB
Prothrombin

1

11

Small-scale

0.501

High

350945

PDGFB
Platelet-derived growth factor subunit B

1

7

Small-scale

0.501

High

358646

CO4A1

1

9

Small-scale

0.501

High

361730

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

3

Small-scale

0.501

High

431436

HS90A
Heat shock protein HSP 90-alpha

1

5

Small-scale

0.501

High

434601

ELNE
Neutrophil elastase

1

20

Small-scale

0.501

High

434604

FGF2
Fibroblast growth factor 2

1

2

Small-scale

0.501

High

434608

TFPI1
Tissue factor pathway inhibitor

1

12

Small-scale

0.501

High

434609

COBA1

1

9

Small-scale

0.501

High

434616

CO5A1

1

9

Small-scale

0.501

High

434619

IBP5
Insulin-like growth factor-binding protein 5

1

9

Small-scale

0.501

High

434620

CALCR
Calcitonin receptor

1

1

Small-scale

0.501

High

434625

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

8

Small-scale

0.501

High

434647

SCRB2
Lysosome membrane protein 2

1

1

Small-scale

0.501

High

434662

HTRA1
Serine protease HTRA1

1

2

Small-scale

0.501

High

434644

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.494

High

149817

RFXK
DNA-binding protein RFXANK

1

12

High-throughput

0.489

High

434627

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.489

High

434629

NEK4
Serine/threonine-protein kinase Nek4

1

9

High-throughput

0.489

High

434666

NPAS1
Neuronal PAS domain-containing protein 1

1

4

High-throughput

0.489

High

434675

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.489

High

434678

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.489

High

170025

PLS1
Phospholipid scramblase 1

1

5

Small-scale

0.481

High

434645

LAMB3
Laminin subunit beta-3

1

18

Small-scale

0.481

High

181041

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.479

High

204942

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.479

High

377017

GCR
Glucocorticoid receptor

1

10

High-throughput

0.479

High

403737

ITB1
Integrin beta-1

1

18

Small-scale

0.479

High

419133

ITAV
Integrin alpha-V

1

2

Small-scale

0.479

High

434606

SPRC
SPARC

1

3

Small-scale

0.479

High

434611

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.479

High

434613

MMP9
Matrix metalloproteinase-9

1

8

Small-scale

0.479

High

434614

VEGFA
Vascular endothelial growth factor A, long form

1

7

Small-scale

0.479

High

434626

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

434655

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.479

High

434665

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

434680

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.479

High

434603

PLEK
Pleckstrin

1

0

Small-scale

0.464

High

434624

MYH9
Myosin-9

1

0

Small-scale

0.458

High

434635

H31
Histone H3.1

1

0

High-throughput

0.458

High

434659

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

434651

ECM1
Extracellular matrix protein 1

1

1

Small-scale

0.457

High

260458

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

434633

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.437

High

434634

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

434639

E2F1
Transcription factor E2F1

1

2

Small-scale

0.437

High

434654

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

434661

ESR2
Estrogen receptor beta

1

10

High-throughput

0.437

High

434674

ANLN
Anillin

1

3

High-throughput

0.437

High

434658

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

434646

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.407

High

127698

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.279

Low

278584

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.279

Low

335233

DYR
Dihydrofolate reductase

1

0

High-throughput

0.279

Low

434643

SCRN3
Secernin-3

1

0

High-throughput

0.279

Low

434656

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

434657

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

434663

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

434664

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.279

Low

434671

AGO3
Protein argonaute-3

1

0

High-throughput

0.279

Low

434672

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

434630

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.249

Low

434673

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

434642

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024